INT134913

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.02
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
nerve 2
capillary 2
astrocytes 2
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 54 99.60 Very High Very High Very High
Dorsal horn 2 99.22 Very High Very High Very High
Hippocampus 25 98.32 Very High Very High Very High
spinal dorsal horn 1 97.96 Very High Very High Very High
Thermal hyperalgesia 1 94.24 High High
intrathecal 1 90.48 High High
Central nervous system 15 86.48 High High
Neuropathic pain 4 83.84 Quite High
Sciatic nerve 2 75.56 Quite High
cytokine 5 67.32 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 1 94.24 High High
Influenza Virus Infection 28 90.28 High High
Neuropathic Pain 4 83.84 Quite High
Viral Infection 1 83.76 Quite High
Pressure And Volume Under Development 1 83.00 Quite High
Spinal Cord Injury 12 81.60 Quite High
INFLAMMATION 2 64.84 Quite High
Encephalopathy 17 63.44 Quite High
Gliosis 1 53.80 Quite High
Disease 4 51.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, 5-bromo-2'-deoxyuridine (BrdU)-positive cells on the ipsilateral dorsal horn of the spinal cord were significantly increased at 7 days after nerve ligation and were highly co-localized with another microglia marker, ionized calcium-binding adaptor molecule 1 (Iba1), but neither with GFAP nor a specific neural nuclei marker, NeuN, in the spinal dorsal horn of nerve-ligated mice.
Positive_regulation (increased) of Localization (co-localized) of GFAP in nerve associated with spinal dorsal horn, dorsal horn and spinal cord
1) Confidence 0.50 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16606373 Disease Relevance 0.33 Pain Relevance 0.88
Interestingly, we noticed that both the increased NOS-2 and GFAP staining were mostly found around capillary blood vessels of the hippocampus starting at an early stage.
Positive_regulation (increased) of Localization (staining) of GFAP in capillary associated with hippocampus
2) Confidence 0.49 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 0.61 Pain Relevance 0.30
The striking observation of the association of the increase of GFAP localization with the increase of FGF-2 immunoreactivity in all regions reveals that FGF-2 was primarily expressed in astrocytes, as previously demonstrated by Van der Wal et al. (1994).
Positive_regulation (increase) of Localization (localization) of GFAP in astrocytes
3) Confidence 0.45 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.08 Pain Relevance 0.11

General Comments

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