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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.58
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) plasma membrane (Aif1) cytoskeleton (Aif1)
cytoplasm (Aif1)
Anatomy Link Frequency
glial cell 1
spinal cord 1
nerve 1
Aif1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 12 99.80 Very High Very High Very High
Spinal cord 55 99.32 Very High Very High Very High
spinal dorsal horn 1 97.00 Very High Very High Very High
intrathecal 30 96.00 Very High Very High Very High
Sciatic nerve 31 95.36 Very High Very High Very High
Lasting pain 14 93.32 High High
Thermal hyperalgesia 7 91.96 High High
Neuropathic pain 72 81.92 Quite High
Brush evoked pain 13 76.48 Quite High
superficial lamina 3 74.20 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 154 95.68 Very High Very High Very High
Pain 43 93.32 High High
Hyperalgesia 10 91.96 High High
Neuropathic Pain 94 81.92 Quite High
Hypersensitivity 11 75.64 Quite High
Nociception 32 70.28 Quite High
Peripheral Neuropathy 26 70.28 Quite High
Sleep Disorders 3 30.88 Quite Low
Nervous System Injury 20 5.00 Very Low Very Low Very Low
INFLAMMATION 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, 5-bromo-2'-deoxyuridine (BrdU)-positive cells on the ipsilateral dorsal horn of the spinal cord were significantly increased at 7 days after nerve ligation and were highly co-localized with another microglia marker, ionized calcium-binding adaptor molecule 1 (Iba1), but neither with GFAP nor a specific neural nuclei marker, NeuN, in the spinal dorsal horn of nerve-ligated mice.
Localization (co-localized) of Iba1 in nerve associated with spinal dorsal horn, dorsal horn and spinal cord
1) Confidence 0.73 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16606373 Disease Relevance 0.32 Pain Relevance 0.86
Western blotting confirmed lower levels of both Iba-1 and p-p38 MAPK protein expression in the dorsal spinal cord (Figure 8) of mice who received cannabidiol at diabetes onset.
Localization (levels) of Iba-1 in spinal cord associated with diabetes mellitus and spinal cord
2) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2845559 Disease Relevance 1.10 Pain Relevance 0.42
No colocalization was observed with glial cell markers glial fibrillary acidic protein (GFAP; astrocytes) nor ionized calcium binding adaptor molecule 1 (Iba1; microglia).
Localization (colocalization) of Iba1 in glial cell
3) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2747840 Disease Relevance 0.16 Pain Relevance 0.72

General Comments

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