INT134944

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Context Info
Confidence 0.06
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 37
Total Number 38
Disease Relevance 10.76
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MOCS1) small molecule metabolic process (MOCS1) nucleus (MOCS1)
Anatomy Link Frequency
endothelial cells 2
reticulum 1
MOCS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 218 99.60 Very High Very High Very High
cytokine 89 98.96 Very High Very High Very High
metalloproteinase 136 97.60 Very High Very High Very High
Catecholamine 14 95.80 Very High Very High Very High
Dopamine 10 93.84 High High
Inflammation 13 93.68 High High
tolerance 8 88.32 High High
Pain 51 87.20 High High
Immobilon 1 79.40 Quite High
antagonist 75 69.04 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 161 99.60 Very High Very High Very High
Suicidal Behaviour 2 99.06 Very High Very High Very High
Gauchers Disease 94 98.46 Very High Very High Very High
Cancer 493 97.62 Very High Very High Very High
Diabetes Mellitus 138 97.44 Very High Very High Very High
Nicotine Addiction 7 96.24 Very High Very High Very High
Disease 148 96.10 Very High Very High Very High
Metabolic Syndrome 24 95.52 Very High Very High Very High
Hyperlipidemia 15 94.80 High High
Hantavirus Infection 156 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enzyme replacement therapy has become the standard of treatment for type I Gaucher disease but remains an expensive option, in part because of the cost of recombinant enzyme production using mammalian cell culture.
Gene_expression (production) of enzyme associated with gauchers disease
1) Confidence 0.06 Published 2006 Journal Biochem. Cell Biol. Section Abstract Doc Link 16609695 Disease Relevance 0.62 Pain Relevance 0.09
Both the 39 and 19 amino acid native GBA signal sequences were capable of endoplasmic reticulum targeting, which led to secretion of the recombinant protein, although approximately 30% more enzyme was produced using the longer signal sequence.
Gene_expression (produced) of enzyme in reticulum
2) Confidence 0.06 Published 2006 Journal Biochem. Cell Biol. Section Abstract Doc Link 16609695 Disease Relevance 0.51 Pain Relevance 0.07
To increase assay sensitivity, the minimum amount of enzyme which produces sufficient signal should be used, and the substrate concentration should be around or below the Km value.
Gene_expression (produces) of enzyme
3) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0 Pain Relevance 0.04
This results in an increased amount of GLA in the lysosomes, as the enhancement of mutant enzyme expression could proportionally increase protein trafficking to the lysosome [29].
Gene_expression (expression) of enzyme
4) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2995157 Disease Relevance 0.27 Pain Relevance 0
IL-1 increased enzyme expression generally but only MMP3 in the NP significantly (p < 0.05), and MMP7/MMP13 (p < 0.05) in the AF.
Gene_expression (expression) of enzyme
5) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.04
By selecting cases for study in which whole IVDs have been excised and by using quantitative image analysis, we have been able to investigate disease mechanisms within those IVD components primarily affected by the processes of degeneration, localize matrix degrading activity within the NP and AF, and correlate matrix degrading activity with enzyme expression.
Gene_expression (expression) of enzyme associated with disease
6) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.10 Pain Relevance 0
Searches for a cause of loss of matrix molecules through largely observational studies of enzyme expression have implicated metal-dependent matrix degrading enzymes (metal-dependent proteases (MDPs) – matrix metalloproteinases (MMPs), metalloproteinases with thrombospondin motifs (ADAMTS)) in matrix degradation in DIVD [3,5-8].
Gene_expression (expression) of enzyme associated with metalloproteinase
7) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.29 Pain Relevance 0.23
/IL-1Ra-treated samples as no other treatment affected enzyme expression.
Gene_expression (expression) of enzyme
8) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.05
Although this is the first study to demonstrate this directly, associations between enzyme expression and the extent of degenerative changes [5,6,32] or duration of symptoms [33] have indicated this should be the case.
Gene_expression (expression) of enzyme
9) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.24 Pain Relevance 0.06
Furthermore, it inhibited enzyme expression when EDTA did not, suggesting IL-1 would be a better clinical target than MDP in the management of DIVD.
Gene_expression (expression) of enzyme
10) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.07 Pain Relevance 0
Experiment 2: localization and semiquantification of matrix degrading enzyme expression in sections used for ISZ
Gene_expression (expression) of enzyme
11) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.04
Medium had no effect on enzyme expression.
Gene_expression (expression) of enzyme
12) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0
IL-1Ra reduced immunodetectable enzyme expression by at least 90% for all enzymes in AF and NP (p < 0.02).


Gene_expression (expression) of enzyme
13) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.05
increased and IL-1Ra decreased enzyme expression in a similar pattern to that in moderately degenerate IVDs.


Gene_expression (expression) of enzyme
14) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.03
Effects of IL-1Ra gene therapy on enzyme expression
Gene_expression (expression) of enzyme
15) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0
In AF and NP, IL-1Ra reduced enzyme expression by at least 90% (p < 0.01).


Gene_expression (expression) of enzyme
16) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.04
Correlation of enzyme activity and protein expression
Gene_expression (expression) of enzyme
17) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.03
Enzyme expression in both regions increased four- to ten-fold with IL-1 treatment (p < 0.01).
Gene_expression (expression) of Enzyme
18) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.05
As such, conventional approaches (for example, enzyme expression, cells in artificial matrices, extraction zymography) that cannot account for the full spectrum of regulatory controls cannot adequately reflect enzyme activity in vivo.
Gene_expression (expression) of enzyme
19) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0
Whilst upstream events driving enzyme production are largely unknown, the cytokine IL-1 has been implicated [10-13].
Gene_expression (production) of enzyme associated with cytokine
20) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.19 Pain Relevance 0.22

General Comments

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