INT134946

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.49
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GBA) hydrolase activity, acting on glycosyl bonds (GBA) cell death (GBA)
carbohydrate metabolic process (GBA) lipid metabolic process (GBA)
Anatomy Link Frequency
viscera 1
bone marrow 1
GBA (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 11 82.64 Quite High
Central nervous system 5 16.20 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
peripheral neuropathy 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gauchers Disease 242 100.00 Very High Very High Very High
Disease 67 100.00 Very High Very High Very High
Targeted Disruption 3 98.80 Very High Very High Very High
Lysosome Storage Disease 4 87.88 High High
Pain 8 82.64 Quite High
Aseptic Necrosis Of Bone 10 79.76 Quite High
Death 6 77.76 Quite High
Osteoporosis 6 66.48 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 65.96 Quite High
Hepatitis 2 65.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Imiglucerase has now been given to more than 5000 patients worldwide and clearly reverses many of the manifestations of Gaucher disease, particularly those affecting the bone marrow and viscera.32 In adults and children, there is a salutary increase in hemoglobin concentration, and white cell, and platelet counts, with a decrease in surrogate biomarkers of disease activity – certain macrophage-related proteins are released abundantly into the circulation in response to cellular storage.33,34
Localization (released) of Imiglucerase in viscera associated with gauchers disease and disease
1) Confidence 0.75 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC3010821 Disease Relevance 0.76 Pain Relevance 0.08
In contrast to imiglucerase and taliglucerase, velaglucerase alpha, the gene-activated human GC, contains the native human enzyme sequence.
Localization (taliglucerase) of imiglucerase
2) Confidence 0.75 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909498 Disease Relevance 0.40 Pain Relevance 0
Secretion of human glucocerebrosidase from stable transformed insect cells using native signal sequences.
Localization (Secretion) of glucocerebrosidase
3) Confidence 0.70 Published 2006 Journal Biochem. Cell Biol. Section Title Doc Link 16609695 Disease Relevance 0.57 Pain Relevance 0.08
Imiglucerase has now been given to more than 5000 patients worldwide and clearly reverses many of the manifestations of Gaucher disease, particularly those affecting the bone marrow and viscera.32 In adults and children, there is a salutary increase in hemoglobin concentration, and white cell, and platelet counts, with a decrease in surrogate biomarkers of disease activity – certain macrophage-related proteins are released abundantly into the circulation in response to cellular storage.33,34
Localization (released) of Imiglucerase in bone marrow associated with gauchers disease and disease
4) Confidence 0.26 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC3010821 Disease Relevance 0.76 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox