INT134951

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.87
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NQO1) small molecule metabolic process (NQO1) oxidoreductase activity (NQO1)
cellular nitrogen compound metabolic process (NQO1) cytoplasm (NQO1)
Anatomy Link Frequency
hepatocytes 1
endothelial cell 1
liver 1
neurons 1
colon 1
NQO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 100.00 Very High Very High Very High
Glutamate 24 99.08 Very High Very High Very High
Inflammation 44 97.24 Very High Very High Very High
Paracetamol 5 97.20 Very High Very High Very High
Analgesic 1 72.80 Quite High
cva 2 54.80 Quite High
cINOD 5 47.68 Quite Low
Ventral tegmentum 9 35.12 Quite Low
midbrain 2 32.88 Quite Low
psoriasis 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 556 98.20 Very High Very High Very High
Hepatotoxicity 3 98.00 Very High Very High Very High
Colon Cancer 43 97.56 Very High Very High Very High
INFLAMMATION 50 97.24 Very High Very High Very High
Overdose 2 96.36 Very High Very High Very High
Biliary Liver Cirrhosis 2 95.88 Very High Very High Very High
Stress 205 95.56 Very High Very High Very High
Non-small-cell Lung Cancer 120 94.72 High High
Targeted Disruption 7 94.00 High High
Stomach Cancer 2 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot and immunohistochemical staining were used to determine patterns of NQO1 expression using a specific antibody against NQO1.
Gene_expression (expression) of NQO1
1) Confidence 0.78 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 16610002 Disease Relevance 0.27 Pain Relevance 0
Similarly, exposure of wild-type C57BL/6x129 Sv mice to nimesulide (100 mg/kg/day, po, for 5 days) was associated with nuclear translocation of immunoreactive Nrf2 in a small number of hepatocytes and induced >2-fold the expression levels of the Nrf2-target gene Nqo1 in wild-type but not Nrf2-null mice.
Gene_expression (expression) of Nqo1 in hepatocytes
2) Confidence 0.75 Published 2010 Journal Chem. Res. Toxicol. Section Abstract Doc Link 20405857 Disease Relevance 0.65 Pain Relevance 0
The concerted higher expression of Nqo1, Nrf2 and other anti-oxidant genes in CA1, in comparison to CA3, is further evidence for the presence of high OS in neurons of this vulnerable region under basal conditions.
Gene_expression (expression) of Nqo1 in neurons associated with stress
3) Confidence 0.70 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.51 Pain Relevance 0
These mice express lower basal levels of the Nrf2 target genes such as NQO1, GST, GCS, UDP-glucuronosyltransferase, glutathione peroxidase-2, and HO-1 (Chan and Kwong 2000; Cho et al. 2002; Hayes et al. 2000; Kwak et al. 2001; McMahon et al. 2001).
Gene_expression (express) of NQO1
4) Confidence 0.64 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.74 Pain Relevance 0.07
H838 cells stably expressing NQO1-ARE luciferase were seeded onto a 24-well dish at a density of 0.2 × 106 cells/ml for 12 h before transfection.
Gene_expression (expressing) of NQO1
5) Confidence 0.62 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0 Pain Relevance 0
AIM: To investigate the expression and activity of NAD(P)H quinone oxidoreductase 1 (NQO1) in human liver specimens obtained from patients with liver damage due to acetaminophen (APAP) overdose or primary biliary cirrhosis (PBC).
Spec (investigate) Gene_expression (expression) of NQO1 in liver associated with biliary liver cirrhosis, paracetamol, hepatotoxicity and overdose
6) Confidence 0.60 Published 2006 Journal World J. Gastroenterol. Section Abstract Doc Link 16610002 Disease Relevance 0.37 Pain Relevance 0.10
These include recent insights into inhibiting cell proliferation by interfering with mitotic spindle microtubule function, decrease Matrix Metalloproteinase (MMP) activity, block the cell cycle in the S or G2/M phases to interfere with processes of cell division, suppress O2(-) generation in leukocytes, inhibit different protein kinases, modulate the signalings, induce carcinogen-detoxifying enzymes glutathione S-transferases (GSTs) and/or NAD(P)H quinine oxidoreductase (NQO1), suppress the phosphorylation of Akt/PKB as a mechanism inhibiting inflammation, progress in structure modification to increase in anti-fungal action, to broaden against bacteria spectrum, to enhance inhibiting activities of nitric oxide synthase (NOS) and cyclooxygenase (COX), to strengthen anti-oxidant activity and to exhibite a much higher cytotoxicity against human umbilical vein endothelial cell (HUVEC).
Gene_expression (quinine) of NQO1 in endothelial cell associated with inflammation and metalloproteinase
7) Confidence 0.57 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19754420 Disease Relevance 0.50 Pain Relevance 0.23
Next, we measured mRNA expression of Nrf2 and its target genes, NQO1 and HO-1, in response to oridonin using real-time RT-PCR.
Gene_expression (expression) of NQO1
8) Confidence 0.56 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.19 Pain Relevance 0
These mice express lower basal levels of the Nrf2 target genes such as NQO1, GST, GCS, UDP-glucuronosyltransferase, glutathione peroxidase-2, and HO-1 (Chan and Kwong 2000; Cho et al. 2002; Hayes et al. 2000; Kwak et al. 2001; McMahon et al. 2001).
Gene_expression (express) of NQO1
9) Confidence 0.56 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.74 Pain Relevance 0.07
As expected, NQO1 and GSR activities and total GSH levels were significantly higher in cancer cells (Figure 5).
Gene_expression (activities) of NQO1 associated with cancer
10) Confidence 0.54 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.17 Pain Relevance 0
Both NQO1 and total GST activities and GSH levels were significantly higher in tumor tissues than in their corresponding normal bronchi (Figure 3B).
Gene_expression (activities) of NQO1 associated with cancer
11) Confidence 0.54 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.87 Pain Relevance 0
Predictably, the NQO1 and GSR enzyme activities and GSH levels were significantly higher in cancer cells.
Gene_expression (activities) of NQO1 associated with cancer
12) Confidence 0.54 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.99 Pain Relevance 0
We measured the transcript levels of NRF2, NQO1, GSR, GCLc, GCLm, MRP1, and MRP2 by real-time RT-PCR.
Gene_expression (levels) of NQO1
13) Confidence 0.48 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.55 Pain Relevance 0
Isothiocyanates induced protein expression of AKR1C1, NAD(P)H:quinone oxidoreductase 1 (NQO1) and heavy subunit of glutamate-cysteine ligase (GCLC) in a colon cancer cell line [43].
Gene_expression (expression) of NQO1 in colon associated with glutamate and colon cancer
14) Confidence 0.27 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.19 Pain Relevance 0.05
The transcriptional response to these agents is typically mediated by the cis-acting antioxidant response element (ARE), found in the promoter of the encoding genes for diverse products such as several glutathione S-transferases, metalloproteinases, NADPH:quinone oxidoreductase 1, UDP glucuronotransferase, ?
Gene_expression (transferases) of quinone oxidoreductase 1 associated with metalloproteinase
15) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.13 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox