INT134955

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.52
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
Cyp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 15 99.96 Very High Very High Very High
Potency 1 55.12 Quite High
Bile 11 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 5 92.64 High High
Severe Combined Immunodeficiency 6 86.00 High High
Targeted Disruption 16 68.08 Quite High
Hepatitis C Virus Infection 9 5.00 Very Low Very Low Very Low
Hepatitis B Virus Infection 8 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Hepatitis 4 5.00 Very Low Very Low Very Low
Viremia 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Liver Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lower basal Cyp1a2 mRNA levels and lower expression of Cyp1a2 and Cyp3a11 mRNAs after APAP dosing were also observed in females compared with males.
Positive_regulation (after) of Transcription (levels) of Cyp1a2 associated with paracetamol
1) Confidence 0.38 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.43 Pain Relevance 1.11
The administration of 3-MC enhanced CYP1A1 and CYP1A2 mRNA levels by 10.0-fold and 6.4-fold, respectively, but had no effect on the other four CYPs.
Positive_regulation (enhanced) of Transcription (levels) of CYP1A2
2) Confidence 0.31 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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