INT134964

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Context Info
Confidence 0.10
First Reported 2002
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 7.45
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ecm1) extracellular space (Ecm1) extracellular region (Ecm1)
proteinaceous extracellular matrix (Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
Anatomy Link Frequency
neuronal 1
neurons 1
skeletal muscle 1
TMJ 1
ECM 1
Ecm1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 80 99.20 Very High Very High Very High
Osteoarthritis 9 98.88 Very High Very High Very High
Snapping jaw 10 98.76 Very High Very High Very High
Mechanotransduction 19 98.60 Very High Very High Very High
Inflammation 159 98.44 Very High Very High Very High
cytokine 48 98.08 Very High Very High Very High
Action potential 46 97.48 Very High Very High Very High
Central nervous system 10 89.52 High High
fibrosis 46 86.08 High High
Inflammatory response 10 81.76 Quite High
Disease Link Frequency Relevance Heat
Disease 29 99.96 Very High Very High Very High
Cancer 77 99.64 Very High Very High Very High
Osteoarthritis 11 98.88 Very High Very High Very High
Temporomandibular Joint Syndrome 10 98.76 Very High Very High Very High
Metastasis 64 98.68 Very High Very High Very High
Asthma 297 98.44 Very High Very High Very High
INFLAMMATION 168 98.44 Very High Very High Very High
Cognitive Disorder 1 96.84 Very High Very High Very High
Emphysema 22 96.32 Very High Very High Very High
Cicatrix 5 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data underscore the importance of the ECM in controlling the structural integrity of the TMJ.
Regulation (importance) of ECM in TMJ associated with snapping jaw
1) Confidence 0.10 Published 2005 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 16612079 Disease Relevance 1.51 Pain Relevance 0.94
The localization of key structural molecules is not affected in the ECM of mutant skeletal muscle
Neg (not) Regulation (affected) of ECM in skeletal muscle
2) Confidence 0.08 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0 Pain Relevance 0
This pathological invasion is thought to occur subsequent to failure of decidualization, highlighting the importance of tight regulation of ECM components in normal decidual function.
Regulation (regulation) of ECM
3) Confidence 0.07 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.03
IL-11 shares many functions with other members of the IL-6 family of cytokines, including the induction of acute phase proteins [11], inhibition of adipogenesis [12] and the regulation of bone ECM metabolism via induction of tissue inhibitor of metalloproteinases (TIMP)-1 [13].
Regulation (regulation) of ECM associated with metalloproteinase and cytokine
4) Confidence 0.07 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.15 Pain Relevance 0.22
Cell surface-bound and soluble MMPs along with their endogenous tissue inhibitors (TIMPs) constitute an important system for regulating ECM turnover; however, MMPs also regulate inflammatory processes [10].
Regulation (regulating) of ECM associated with inflammation and metalloproteinase
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.33 Pain Relevance 0.60
levels may alter the ECM assembly process, it is likely that the raised TGF?
Spec (may) Regulation (alter) of ECM
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.17 Pain Relevance 0.04
The deposition of FBLN-1 in the ECM was assessed using an ECM ELISA according to methods described previously [29].
Regulation (using) of ECM
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.08 Pain Relevance 0
dependent ECM regulatory proteins
Regulation (regulatory) of ECM
8) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0 Pain Relevance 0
, via Smad pathway, regulates ECM-related proteins, including the profibrotic mediator CTGF [4], [26], the inhibitor of ECM degradation, PAI-1, [27], and the main ECM component Type I Collagen (Col-1) [4].
Regulation (regulates) of ECM-related
9) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0 Pain Relevance 0
In addition, in disorders such as Alzheimer's disease, alterations in the ECM may be related to diminished synaptic plasticity and therefore play a role in cognitive dysfunction.
Regulation (alterations) of ECM associated with cognitive disorder and disease
10) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0.20 Pain Relevance 0.19
The architecture of the asthmatic airway often undergoes prominent and permanent structural changes, including alterations of the molecular composition of the ECM.
Regulation (alterations) of ECM associated with asthma
11) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.17 Pain Relevance 0.03
In keeping with the latter, expression microarray data has revealed that genes encoding ECM remodeling proteins are frequently over-expressed within the tumor stroma, and that dysregulation of ECM-relevant genes is predictive of metastasis in both mouse and human mammary cancers [8], [9].
Regulation (dysregulation) of ECM in ECM associated with cancer and metastasis
12) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.85 Pain Relevance 0
We hypothesize that the serine protease/inhibitor pair act by altering the ECM through which GnRH neurons migrate.
Regulation (altering) of ECM in neurons
13) Confidence 0.01 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0 Pain Relevance 0
Though we did not localize PAR expression in our model system, it remains a possibility that their activation or inhibition may modulate the ECM composition and thus GnRH neuronal migration.
Spec (may) Regulation (modulate) of ECM in neuronal
14) Confidence 0.01 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0.08 Pain Relevance 0
Furthermore, the structural alterations in ECM proteins may provoke an immune reaction, whereas degradation fragments generated during extensive tissue remodeling may lead to antigenic fragments also provoking an immune reaction.
Regulation (alterations) of ECM
15) Confidence 0.01 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.66 Pain Relevance 0.12
Effect of ECM and neurites on stretch-activated mechanotransduction
Regulation (Effect) of ECM in neurites associated with mechanotransduction
16) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627935 Disease Relevance 0.24 Pain Relevance 0.19

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