INT134965

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 7.86
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ecm1) extracellular space (Ecm1) extracellular region (Ecm1)
proteinaceous extracellular matrix (Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
Anatomy Link Frequency
ECM 1
lung 1
Ecm1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 69 100.00 Very High Very High Very High
Pain 3 99.68 Very High Very High Very High
imagery 27 98.88 Very High Very High Very High
fibrosis 54 98.64 Very High Very High Very High
Osteoarthritis 5 93.84 High High
Snapping jaw 10 93.72 High High
ischemia 4 91.92 High High
Bile 2 60.08 Quite High
corticosteroid 16 50.24 Quite High
Inflammation 110 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cerebral Malaria 76 100.00 Very High Very High Very High
Asthma 380 99.76 Very High Very High Very High
Pain 3 99.68 Very High Very High Very High
Injury 200 98.92 Very High Very High Very High
Infection 26 98.84 Very High Very High Very High
Apoptosis 27 98.72 Very High Very High Very High
Fibrosis 70 98.64 Very High Very High Very High
Osteoarthritis 5 93.84 High High
Temporomandibular Joint Syndrome 10 93.72 High High
Cataract 68 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data show that there is a redistribution of the critical ECM protein, type II collagen, in mutant mice compared with controls.
Negative_regulation (redistribution) of ECM in ECM
1) Confidence 0.18 Published 2005 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 16612079 Disease Relevance 1.63 Pain Relevance 1.04
We did not observe any additive effect on wound repair or proliferation when FBLN-1C in both ASM and ECM was downregulated (data not shown), which suggests that decreasing FBLN-1C in either component is adequate to inhibit these cellular processes.
Negative_regulation (downregulated) of ECM associated with injury
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.94 Pain Relevance 0
ECM in which FBLN-1C was suppressed was produced using the FBLN-1C AO and prepared as described above.
Negative_regulation (suppressed) of ECM
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.66 Pain Relevance 0
The most consistently reported side effect was musculoskeletal pain, likely due to inhibition of adaptive ECM remodeling; however, spontaneous fibrosis formation has never been reported.
Negative_regulation (inhibition) of ECM associated with fibrosis and pain
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.01 Pain Relevance 0.32
increased FBLN-1 deposition in the ECM from asthmatic ASM cells (P<0.01, figure 4B).
Negative_regulation (deposition) of ECM associated with asthma
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.36 Pain Relevance 0.03
The deposition of FBLN-1 in the ECM was assessed using an ECM ELISA according to methods described previously [29].
Negative_regulation (deposition) of ECM
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.09 Pain Relevance 0
R prevented ECM development.
Negative_regulation (prevented) of ECM associated with cerebral malaria
7) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442868 Disease Relevance 0.91 Pain Relevance 0.14
Relevant to the disc, tissue inhibitor of metalloproteinase-1 and ECM fragments, including those from collagen, merit further study of their anti-angiogenic potential.
Negative_regulation (inhibitor) of ECM associated with metalloproteinase
8) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.14 Pain Relevance 0.05
SMA expression within 4 days, which was sufficient to further induce aberrant deposition of ECM in mice out to 21 days post infection.
Negative_regulation (deposition) of ECM associated with infection
9) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2647562 Disease Relevance 1.06 Pain Relevance 0.04
These surface-bound proteinases potently degrade lung ECM proteins and proteinase inhibitors and induce goblet cell degranulation (Takeyama et al 1998; Owen et al 1995b, 2003b, 2004).
Negative_regulation (inhibitors) of ECM in lung
10) Confidence 0.02 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.06 Pain Relevance 0.08

General Comments

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