INT134966

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 16.40
Pain Relevance 5.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
platelet 3
Mouse 2
T-cell 2
plasma 1
PSC 1
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 637 99.40 Very High Very High Very High
agonist 31 99.20 Very High Very High Very High
Inflammation 322 98.88 Very High Very High Very High
fibrosis 356 98.84 Very High Very High Very High
Chronic pancreatitis 8 97.78 Very High Very High Very High
Kinase C 450 97.00 Very High Very High Very High
Osteoarthritis 12 93.84 High High
Snapping jaw 10 93.72 High High
rheumatoid arthritis 225 93.28 High High
Inflammatory response 49 92.32 High High
Disease Link Frequency Relevance Heat
Adhesions 81 100.00 Very High Very High Very High
Immunization 74 100.00 Very High Very High Very High
Arthritis 704 99.40 Very High Very High Very High
Keloid Scars 7 99.16 Very High Very High Very High
Pulmonary Fibrosis 232 99.04 Very High Very High Very High
Muscle Disease 52 98.96 Very High Very High Very High
INFLAMMATION 361 98.88 Very High Very High Very High
Apoptosis 130 98.72 Very High Very High Very High
Necrosis 16 98.60 Very High Very High Very High
Fibrosis 202 98.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The plasma-induced enhanced hydrophilicity of silicone led to optimization of collagen binding on implants surface.
Localization (optimization) of collagen in plasma
1) Confidence 0.42 Published 2010 Journal Eplasty Section Body Doc Link PMC2948451 Disease Relevance 0.24 Pain Relevance 0
There were no apparent differences in the localization of desmin, vimentin, type I, IV or VI collagen between wild-type and mutant tissues at 3 weeks of age, confirming that it was not a generalized myopathy (data not shown).


Localization (localization) of collagen associated with muscle disease
2) Confidence 0.36 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.24 Pain Relevance 0
Alcoholic chronic pancreatitis (ACP) is characterized by pancreatic necrosis, inflammation, and scarring, the latter of which is due to excessive collagen deposition by activated pancreatic stellate cells (PSC).
Localization (deposition) of collagen in PSC associated with necrosis, inflammation, primary sclerosing cholangitis, keloid scars and chronic pancreatitis
3) Confidence 0.21 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20368699 Disease Relevance 0.90 Pain Relevance 0.49
Collagen fiber appearance of prostatic stroma of anterior lobe in five young and old mice was compared using 4 images from each sample taken at 400X magnification.
Localization (appearance) of Collagen in anterior lobe
4) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0 Pain Relevance 0
We also show that B6 mice develop a sustained T-cell response to chicken collagen as well as to autologous (mouse) collagen.


Localization (response) of collagen in T-cell
5) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 1.24 Pain Relevance 0.30
We also show that B6 mice develop a sustained T-cell response to chicken collagen as well as to autologous (mouse) collagen.


Localization (response) of collagen in T-cell
6) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 1.24 Pain Relevance 0.30
Briefly, left lung lobes were homogenized and collagen was solubilized in 0.5 M acetic acid.
Localization (solubilized) of collagen in lobes
7) Confidence 0.12 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.23 Pain Relevance 0.08
Our data show that there is a redistribution of the critical ECM protein, type II collagen, in mutant mice compared with controls.
Localization (redistribution) of collagen in ECM
8) Confidence 0.11 Published 2005 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 16612079 Disease Relevance 1.64 Pain Relevance 1.05
In severe and moderately severe OI (generally due to a structural defect of type I collagen synthesis) agents increasing the production of type I collagen, such as GH, do not represent a suitable treatment, other agents that reduce bone resorption, such as BPs, are preferable for their action in increasing BMC.
Localization (such) of collagen associated with osteogenesis imperfecta and hypercalcemia
9) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.72 Pain Relevance 0
To test the hypothesis that myopathy is specifically associated with CTD-COMP mutations localised near the potential collagen and integrin binding sites, we have investigated a second mouse model, COMP ?
Localization (localised) of collagen associated with muscle disease
10) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 1.03 Pain Relevance 0
There was no elevation of bovine collagen-specific antibodies in response to either unprocessed or photooxidized bovine osteochondral grafts.
Neg (no) Localization (elevation) of collagen
11) Confidence 0.09 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0.07 Pain Relevance 0.18
Mouse serum IgG anti-collagen antibody concentration after collagen immunization is not increased in selectin mutant compared with wild-type mice in pre-CIA onset mice
Localization (immunization) of collagen in Mouse associated with immunization and arthritis
12) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.69 Pain Relevance 0.25
in their hind joints compared with wild-type mice, without collagen immunization.
Localization (immunization) of collagen in joints associated with immunization
13) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.95 Pain Relevance 0.49
Mouse serum IgG anti-collagen antibody concentration after collagen immunization is not increased in selectin mutant compared with wild-type mice in pre-CIA onset mice
Localization (immunization) of collagen in Mouse associated with immunization and arthritis
14) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.70 Pain Relevance 0.25
2 downstream of the major platelet signaling receptor for collagen, the immunoglobulin GPVI [21], we investigated platelet aggregation and secretion responses to collagen and the GPVI-specific agonist CRP alongside responses to thrombin using WT and HS1-/- platelets.
Spec (investigated) Localization (secretion) of collagen in platelets associated with agonist
15) Confidence 0.07 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0 Pain Relevance 0.15
The matrigel in the needle makes it difficult to extract the RNA due to the abundance of proteins and collagen.
Localization (abundance) of collagen
16) Confidence 0.06 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC194589 Disease Relevance 0.74 Pain Relevance 0
For measurement of collagen-specific autoantibodies, chicken collagen (1 µg/ml) was coated on the plate overnight at 4 °C, and biotin-conjugated anti-mouse IgG, IgG1, IgG2a, and IgG2b antibodies (BD, San Jose, CA) were used as detection antibodies.
Localization (measurement) of collagen
17) Confidence 0.05 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.40 Pain Relevance 0.04
We quantified the Gr-1+ Mac-1+ neutrophils in peripheral blood in the CIA model on day 2 after primary collagen immunization.
Localization (immunization) of collagen in blood associated with immunization and arthritis
18) Confidence 0.05 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.21 Pain Relevance 0.29
Measurement of Single Platelet Adhesion to Collagen
Localization (Measurement) of Collagen in Platelet associated with adhesions
19) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.44 Pain Relevance 0.10
-granule and dense granule secretion (18, 19) and platelet aggregate formation (20) in response to collagen and other platelet agonists (21).
Localization (secretion) of collagen in platelet associated with agonist
20) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0 Pain Relevance 0.56

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