INT134967

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Context Info
Confidence 0.29
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 66
Total Number 67
Disease Relevance 38.40
Pain Relevance 7.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ecm1) extracellular space (Ecm1) extracellular region (Ecm1)
proteinaceous extracellular matrix (Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
Anatomy Link Frequency
ECM 7
fibroblast 3
stroma 2
PSCs 2
skeletal muscle 2
Ecm1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 258 99.74 Very High Very High Very High
metalloproteinase 240 99.56 Very High Very High Very High
fibrosis 461 99.48 Very High Very High Very High
imagery 155 99.30 Very High Very High Very High
Inflammation 411 98.72 Very High Very High Very High
ischemia 57 96.44 Very High Very High Very High
Snapping jaw 20 96.12 Very High Very High Very High
Osteoarthritis 64 95.96 Very High Very High Very High
antagonist 45 94.24 High High
dexamethasone 94 93.24 High High
Disease Link Frequency Relevance Heat
Asthma 760 100.00 Very High Very High Very High
Fibrosis 596 100.00 Very High Very High Very High
Cerebral Malaria 442 100.00 Very High Very High Very High
Adhesions 100 100.00 Very High Very High Very High
Glioma 34 100.00 Very High Very High Very High
Apoptosis 252 99.90 Very High Very High Very High
Thrombocytopenia 20 99.84 Very High Very High Very High
Cataract 136 99.70 Very High Very High Very High
Cyst 1 99.70 Very High Very High Very High
Cirrhosis 133 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We speculate that the overall imbalance in apoptosis may be the cellular basis for the abnormal production of structural ECM proteins.
Gene_expression (production) of ECM in ECM associated with apoptosis
1) Confidence 0.29 Published 2005 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 16612079 Disease Relevance 1.53 Pain Relevance 0.99
The abnormal production of the ECM could, in turn, lead to premature erosion and degradation of the articular surface resulting in TMJ-OA.
Gene_expression (production) of ECM in TMJ associated with snapping jaw and osteoarthritis
2) Confidence 0.22 Published 2005 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 16612079 Disease Relevance 1.51 Pain Relevance 0.98
Fibulin-4 is an extracellular matrix protein expressed by vascular smooth muscle cells that is essential for maintaining arterial integrity.
Gene_expression (expressed) of extracellular matrix protein in smooth muscle cells
3) Confidence 0.11 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1794134 Disease Relevance 0.16 Pain Relevance 0.04
Using mRNA and protein expression studies alone, it is not possible to determine whether IL-11 affects ECM molecule expression directly or indirectly.
Gene_expression (expression) of ECM
4) Confidence 0.11 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.04
Given that IL-11 is a secreted cytokine with autocrine and paracrine activity, a direct effect on ECM molecule transcription would be dependent on coincident expression patterns of the ECM molecules, IL-11 and its receptors.
Gene_expression (expression) of ECM associated with cytokine
5) Confidence 0.11 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.10
The ECM genes COL3A1, SPARC, BGN and NID1 were among those upregulated in IL11Ra-/- uterus compared to wild type.
Gene_expression (genes) of ECM in uterus
6) Confidence 0.09 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
The most abundant gene transcript was Col1a1, which was unsurprising since type I collagen is the most abundant protein of tendon and ligament and an abundant component of the skeletal muscle ECM.
Gene_expression (component) of ECM in skeletal muscle
7) Confidence 0.09 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.06 Pain Relevance 0
We have also confirmed that COMP was present in the ECM of skeletal muscle, specifically in the endo- and perimysium, and that there were no differences in its localization between wild-type and mutant tissues.
Gene_expression (present) of ECM in skeletal muscle
8) Confidence 0.09 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.56 Pain Relevance 0
In both wild-type and mutant tendon, COMP was present in the ECM between individual collagen fibrils (Fig. 3A; data not shown), confirming previous studies (35,36).
Gene_expression (present) of ECM in tendon
9) Confidence 0.09 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.07 Pain Relevance 0
To assess the functional contribution of TLR2 to the development of tubular injury and interstitial fibrosis in UUO, we next scored for histological signs of renal injury and analyzed the expression of the major ECM component collagen.
Spec (analyzed) Gene_expression (expression) of ECM component collagen associated with fibrosis, ureteral obstruction and injury
10) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682651 Disease Relevance 1.75 Pain Relevance 0.09
The disease process is characterized by alveolar epithelial cell injury and hyperplasia, inflammatory cell accumulation, fibroblast hyperplasia, formation of honeycomb cysts and exuberant production and deposition of extracellular matrix (ECM) components, particularly collagen and fibronectin along with scar tissue formation [2,4].
Gene_expression (production) of ECM in epithelial cell associated with cicatrix, inflammation, injury, cyst, disease and hyperplasia
11) Confidence 0.08 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 1.28 Pain Relevance 0.22
Additional ECM molecules expressed in terminally differentiated chondrocytes such as collagen 10 (Col10a1) and osteonectin (Spock1) were identified, suggesting that this molecular classification is important for transmitting GC signaling in the growth plate.
Gene_expression (expressed) of ECM in chondrocytes
12) Confidence 0.08 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.15 Pain Relevance 0.23
In adult CNS, ECM molecules, such as chondroitin sulfate proteoglycans (CSPG) and tenascin, are expressed at low levels; however, injury can elicit a prominent increase in their expression, which is primarily associated with reactive astrocytes surrounding the injury site.
Gene_expression (expressed) of ECM in astrocytes associated with injury
13) Confidence 0.08 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.59 Pain Relevance 0
Levels of FBLN-1 in the ECM were the same in unstimulated non-asthmatic and asthmatic ECM (figure 4A).
Gene_expression (Levels) of ECM associated with asthma
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.28 Pain Relevance 0.03
To produce ECM with suppressed FBLN-1C expression, ASM cells were seeded in 75 cm2 flasks and transfected as described above.
Gene_expression (produce) of ECM
15) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0 Pain Relevance 0
ECM in which FBLN-1C was suppressed was produced using the FBLN-1C AO and prepared as described above.
Gene_expression (produced) of ECM
16) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.67 Pain Relevance 0
Importantly, proliferation of asthmatic ASM cells was decreased when the cells were seeded onto an ECM produced by FBLN-1C AO treated cells (figure 10).
Gene_expression (produced) of ECM associated with asthma
17) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 1.73 Pain Relevance 0
To confirm the altered mRNA expression of the ECM genes COL3A1, SPARC, BGN and NID1 at 48 h of decidualization, quantitative real-time RT-PCR was carried out using the same RNA samples used in the microarray analysis, plus two additional RNA samples of each genotype, collected in the same way.
Gene_expression (expression) of ECM
18) Confidence 0.08 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
Furthermore, interactions between integrins expressed by glioma cells and the ECM and the activity of MMPs form the basis for glioma cell migration and invasion [17].
Gene_expression (expressed) of ECM associated with metalloproteinase and glioma
19) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 1.24 Pain Relevance 0.21
-mediated ECM production.
Gene_expression (production) of ECM
20) Confidence 0.07 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597201 Disease Relevance 0.71 Pain Relevance 0.04

General Comments

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