INT134968

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 20
Total Number 28
Disease Relevance 27.27
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ecm1) extracellular space (Ecm1) extracellular region (Ecm1)
proteinaceous extracellular matrix (Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
Anatomy Link Frequency
ECM 10
muscle 1
cartilage 1
anterior 1
skeletal muscle 1
Ecm1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 172 100.00 Very High Very High Very High
chemokine 37 100.00 Very High Very High Very High
Arthritis 64 99.48 Very High Very High Very High
Inflammation 677 98.88 Very High Very High Very High
fibrosis 108 98.40 Very High Very High Very High
corticosteroid 7 95.28 Very High Very High Very High
Osteoarthritis 24 93.84 High High
Snapping jaw 10 93.72 High High
Inflammatory response 51 84.88 Quite High
rheumatoid arthritis 77 82.48 Quite High
Disease Link Frequency Relevance Heat
Cerebral Malaria 76 100.00 Very High Very High Very High
Apoptosis 154 99.90 Very High Very High Very High
Injury 256 99.48 Very High Very High Very High
Arthritis 112 99.48 Very High Very High Very High
Cataract 146 99.30 Very High Very High Very High
Cancer 330 99.10 Very High Very High Very High
INFLAMMATION 706 98.88 Very High Very High Very High
Cirrhosis 16 98.44 Very High Very High Very High
Fibrosis 123 98.40 Very High Very High Very High
Necrosis 42 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data show that there is a redistribution of the critical ECM protein, type II collagen, in mutant mice compared with controls.
Localization (redistribution) of ECM in ECM
1) Confidence 0.32 Published 2005 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 16612079 Disease Relevance 1.63 Pain Relevance 1.04
We used immunohistochemistry to determine the localization of several important ECM proteins in murine skeletal muscle and did not detect any differences in the distribution of wild-type and mutant COMP, or in the distribution of types I, IV and VI collagen, desmin or vimentin.
Spec (determine) Localization (localization) of ECM in skeletal muscle
2) Confidence 0.11 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.62 Pain Relevance 0
Interestingly, these observations are in direct contrast to changes in the localization of mutant COMP seen in the cartilage growth plates of Comp T585M mutant mice (20) and suggests that the ECM of muscle and cartilage may assemble and respond differently to the presence of mutant COMP.
Localization (presence) of ECM in muscle
3) Confidence 0.10 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.51 Pain Relevance 0
COMP is an extracellular matrix protein initially found in cartilage but recently also shown to be secreted by synovial fibroblasts.
Localization (secreted) of extracellular matrix protein in extracellular matrix
4) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 0.61 Pain Relevance 0.12
Matrix metalloproteases (MMPs) have long been known to exert a myriad of regulatory actions critical in tissue repair and remodelling, including epithelial cell migration, proliferation, differentiation, and apoptosis, as well as release of latent or bound growth factors from the ECM [29].
Localization (release) of ECM in epithelial cell associated with apoptosis
5) Confidence 0.10 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.53 Pain Relevance 0.14
R expression on stromal cells determines resistance to ECM
Spec (determines) Localization (resistance) of ECM in stromal cells associated with cerebral malaria
6) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442868 Disease Relevance 1.14 Pain Relevance 0
Hepatocellular injury usually leads to inflammation and activation of the innate immune system, leading to release of growth factors, cytokines and small molecular mediators that can stimulate extracellular matrix (ECM) synthesis by activation of quiescent hepatic stellate cells and fibroblasts/myofibroblasts (collectively named HSCs) [1], [2].
Localization (release) of ECM in immune system associated with cirrhosis, inflammation, injury and cytokine
7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.42 Pain Relevance 0.46
In our model atorvastatin increases ECM accumulation what leads to a strengthening of the fibrous cap, while apoptosis was not detectable.
Localization (accumulation) of ECM associated with apoptosis
8) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 1.66 Pain Relevance 0.08
to activate the Smads; being this pathway essential for statin dependent effects on VSMCs, including apoptosis and ECM accumulation.
Localization (accumulation) of ECM associated with apoptosis
9) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.61 Pain Relevance 0.03
Others are extracellular matrix (ECM) molecule fragments that are released upon tissue damage or ECM molecules that are specifically upregulated in response to tissue injury [6].
Localization (released) of extracellular matrix in ECM associated with injury
10) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.87 Pain Relevance 0.26
Others are extracellular matrix (ECM) molecule fragments that are released upon tissue damage or ECM molecules that are specifically upregulated in response to tissue injury [6].
Localization (released) of ECM in ECM associated with injury
11) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.86 Pain Relevance 0.26
Appropriate annular morphology and integrity are essential to the function of the intervertebral disc, and cells in the outer annulus are polarized for directed secretion of ECM components [24].
Localization (secretion) of ECM in annulus
12) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.34 Pain Relevance 0.08
DAMPening Inflammation by Modulating TLR Signalling

Damage-associated molecular patterns (DAMPs) include endogenous intracellular molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules that are upregulated upon injury or degraded following tissue damage.

Localization (released) of ECM in extracellular matrix associated with inflammation and injury
13) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Title Doc Link PMC2913853 Disease Relevance 1.00 Pain Relevance 0.29
Others are extracellular matrix (ECM) molecule fragments that are released upon tissue damage or ECM molecules that are specifically upregulated in response to tissue injury [6].
Localization (released) of ECM in ECM associated with injury
14) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.87 Pain Relevance 0.27
Other DAMPs including the S100 proteins are also secreted in the same way [181] and targeting this pathway therefore may potentially offer a means to modulate the release of intracellular DAMPs.One class of DAMPs comprises ECM fragments generated by release from intact matrices.
Localization (release) of ECM
15) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.51 Pain Relevance 0.06
DAMPening Inflammation by Modulating TLR Signalling

Damage-associated molecular patterns (DAMPs) include endogenous intracellular molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules that are upregulated upon injury or degraded following tissue damage.

Localization (released) of extracellular matrix in extracellular matrix associated with inflammation and injury
16) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Title Doc Link PMC2913853 Disease Relevance 1.00 Pain Relevance 0.29
Recently, SPARC (secreted protein, acidic and rich in cysteine), a matricellular component of the ECM, has been reported as a bio-marker for fibrosis in multiple fibrotic diseases, such as interstitial pulmonary fibrosis, renal interstitial fibrosis, cirrhosis, atherosclerotic lesions and scleroderma or systemic sclerosis (SSc) [4-9].
Localization (secreted) of ECM associated with fibrosis, cirrhosis, atherosclerosis, pulmonary fibrosis, systemic sclerosis and disease
17) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 1.56 Pain Relevance 0.31
In PCO, the LECs which remain within the capsule after cataract surgery are triggered to proliferate and migrate to the posterior lens capsule [13] and like ASC, some of these cells undergo a transition into myofibroblasts that secrete aberrant ECM.
Localization (secrete) of ECM in ECM associated with cataract
18) Confidence 0.05 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2647562 Disease Relevance 1.10 Pain Relevance 0
As the cataracts further develop, the plaque cells secrete extracellular matrix (ECM) components not found in the normal lens, such as collagen type I and IV, contributing to the loss of lens transparency.
Localization (secrete) of ECM in ECM associated with cataract
19) Confidence 0.05 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2647562 Disease Relevance 1.43 Pain Relevance 0.05
Inhibition of this process has been demonstrated; for example, release of immune-stimulatory HS fragments from the ECM in vivo can be mediated by the proteolytic action of elastase [182].
Localization (release) of ECM
20) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.54 Pain Relevance 0.06

General Comments

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