INT13499

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Context Info
Confidence 0.76
First Reported 1984
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 68
Total Number 68
Disease Relevance 35.64
Pain Relevance 10.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Agtr2) plasma membrane (Agtr2) transcription factor binding (Agtr2)
signal transducer activity (Agtr2)
Anatomy Link Frequency
body 3
retina 2
fibroblasts 2
stroma 1
macrophage 1
Agtr2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 246 100.00 Very High Very High Very High
Neuropeptide 4 99.98 Very High Very High Very High
Physical dependence 2 99.98 Very High Very High Very High
agonist 26 99.96 Very High Very High Very High
Morphine 17 99.80 Very High Very High Very High
Endogenous opioid 6 99.76 Very High Very High Very High
Enkephalin 15 99.40 Very High Very High Very High
amygdala 3 99.40 Very High Very High Very High
bradykinin 1 99.40 Very High Very High Very High
Inflammation 282 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 2 100.00 Very High Very High Very High
Drug Dependence 5 99.98 Very High Very High Very High
Reprotox - General 1 4 99.88 Very High Very High Very High
Apoptosis 462 99.78 Very High Very High Very High
Diabetes Mellitus 671 99.74 Very High Very High Very High
Infection 148 99.62 Very High Very High Very High
Cancer 2577 99.60 Very High Very High Very High
Cytomegalovirus Infection 192 99.42 Very High Very High Very High
Hypertrophy 12 99.10 Very High Very High Very High
Increased Venous Pressure Under Development 39 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effects of candesartan were selective and were similar in animals pretreated with enalaprilat (1 mg/kg iv) to reduce endogenous angiotensin II production.
Gene_expression (production) of angiotensin II
1) Confidence 0.76 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10567010 Disease Relevance 0 Pain Relevance 0.07
Angiotensin II (0.1-10 pmol), given intracerebroventricularly (i.c.v.), had no effect on the nociceptive sensitivity but did produce a dose-dependent attenuation of the morphine-induced analgesia.
Gene_expression (produce) of Angiotensin II associated with nociception, analgesia and morphine
2) Confidence 0.67 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 4080108 Disease Relevance 0.10 Pain Relevance 1.03
Intraventricular injection of angiotensin II in mice resulted in an increase in 1.5% NaCl intake, which was blocked by naloxone.
Gene_expression (injection) of angiotensin II associated with narcan
3) Confidence 0.67 Published 1984 Journal Appetite Section Abstract Doc Link 6385842 Disease Relevance 0.33 Pain Relevance 0.41
Since AT2 receptor expression has been noted in various stromal fibroblasts [23,24] and is inducible in the pancreas in pathological conditions [25], AT2 receptor deficiency may also influence pancreatic cancer growth.
Gene_expression (expression) of AT2 receptor in pancreas associated with pancreatic cancer
4) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.65 Pain Relevance 0.04
Results clearly indicate that AT2 receptor over-expression significantly attenuates growth of co-cultured PAN02 cells.
Gene_expression (over) of AT2 receptor
5) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.69 Pain Relevance 0.03
Following the in vivo mouse study, in vitro studies were carried out to determine the mechanism by which AT2 receptor expression in stromal cells modifies the growth of pancreatic carcinoma cells.
Gene_expression (expression) of AT2 receptor in stromal cells associated with pancreatic cancer
6) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.90 Pain Relevance 0
In the first in vitro experiment, the effect of AT2 receptor over-expression in either wild type or AT2-KO MSFs was evaluated in co-culture with PAN02 cells.
Gene_expression (over) of AT2 receptor
7) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.74 Pain Relevance 0
PCR products of the AT2 receptor (478 bp) and Neo-r gene product (593 bp) were visualized by 1% agarose gel electrophoresis.
Gene_expression (products) of AT2 receptor
8) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.13 Pain Relevance 0.03
Since the contribution of MSFs to cell proliferation is approximately one third of the total cell proliferation (MSF + PAN02), since MSF cell proliferation was not influenced by the status of AT2 receptor expression (Figure 5) nor by the presence of Ang II or the AT2 antagonist (data not shown), and since PAN02 cells do not express Ang II receptors, the growth of PAN02 cells appears to be indirectly regulated by the MSFs.
Gene_expression (expression) of AT2 receptor associated with antagonist
9) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.25 Pain Relevance 0.05
The second major isoform, the AT2 receptor, is abundantly expressed in fetal tissues, but its expression declines rapidly after birth [14].
Gene_expression (expressed) of AT2 receptor
10) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.68 Pain Relevance 0
The AT2 receptor, the second major isoform of the Ang II receptor, is primarily expressed in the mesenchyme of the fetus and to a limited extent in adult tissues [13].
Gene_expression (expressed) of AT2 receptor in mesenchyme
11) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.49 Pain Relevance 0
Therefore, in this study we sought to evaluate the role of AT2 receptor expression in stroma in the growth of pancreatic ductal adenocarcinoma, the most common form of pancreatic cancer.
Gene_expression (expression) of AT2 receptor in stroma associated with adenocarcinoma and pancreatic cancer
12) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.87 Pain Relevance 0
In the first in vitro experiment, the effect of AT2 receptor over-expression in either wild type or AT2-KO MSFs was evaluated in co-culture with PAN02 cells.
Gene_expression (expression) of AT2
13) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.73 Pain Relevance 0.03
Since real time PCR revealed that primary cultured wild type mouse skin fibroblasts express the AT2 receptor, but PAN02 cells do not (Table 1), these results indicate that the host stromal AT2 receptor is involved in the growth of PAN02 xenografts.


Gene_expression (express) of AT2 receptor in fibroblasts
14) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.85 Pain Relevance 0
Briefly, published sequences [19,32] were used to synthesize primers for the AT2 receptor (forward 5'-CACCAGCAGAAACATTAC-3' and reverse 5'-AACACAGCTGTTGAATCC-3') and the neomycin resistance (Neo-r) gene product (forward 5'-AGCCAACGCTATGTCCTGAT-3' and reverse 5'-AGACAATCGGCTGCTCTGAT-3').
Gene_expression (synthesize) of AT2 receptor
15) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.21 Pain Relevance 0
This suggests that AT2 receptor expression potentially plays an important role in cancer.
Gene_expression (expression) of AT2 receptor associated with cancer
16) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 1.00 Pain Relevance 0.05
Ang II only slightly increased the growth of PAN02 cells regardless of cell sources (wild type or AT2-KO mice) or AT2 expression in MSFs.
Gene_expression (expression) of AT2
17) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.24 Pain Relevance 0.08
These results indicate that AT2 expression in co-cultured MSFs plays a negative role in cell proliferation of PAN02 cells and this effect can be reversed by the AT2 receptor blockade.


Gene_expression (expression) of AT2
18) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.07 Pain Relevance 0.08
Evaluation of the effect of AT2 receptor over-expression in fibroblasts on co-cultured PAN02 cell growth
Gene_expression (over-expression) of AT2 receptor in fibroblasts
19) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0 Pain Relevance 0.04
Although these studies did not clarify the potential second messenger that controls cell growth, the present study suggests that AT2 receptor-mediated attenuation of VEGF production is a potential mechanism for AT2 receptor expression-dependent growth attenuation of pancreatic carcinoma.
Gene_expression (expression) of AT2 receptor associated with pancreatic cancer
20) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.52 Pain Relevance 0

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