INT135000

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.27
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRM2) intracellular (GRM2) signal transducer activity (GRM2)
Anatomy Link Frequency
spinal 2
synapses 2
GRM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 12 99.98 Very High Very High Very High
allodynia 8 99.90 Very High Very High Very High
opiate 6 99.76 Very High Very High Very High
Hyperalgesia 10 99.40 Very High Very High Very High
Inflammation 32 99.14 Very High Very High Very High
agonist 11 98.34 Very High Very High Very High
nMDA receptor 4 97.60 Very High Very High Very High
Pain 88 97.42 Very High Very High Very High
antagonist 16 96.24 Very High Very High Very High
nMDA receptor antagonist 1 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 20 99.90 Very High Very High Very High
Hyperalgesia 11 99.40 Very High Very High Very High
INFLAMMATION 40 99.14 Very High Very High Very High
Pain 118 97.42 Very High Very High Very High
Injury 10 95.18 Very High Very High Very High
Nociception 9 59.16 Quite High
Stroke 1 51.52 Quite High
Frailty 48 50.00 Quite Low
Arthritis 4 50.00 Quite Low
Recurrence 1 42.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that opiate withdrawal induces dynamic expression of GluR1 and GluR2/3 subunits of AMPA receptors in hippocampal synapses, possibly revealing an adaptive process of the hippocampal functions following opiate withdrawal.
Spec (possibly) Positive_regulation (induces) of Gene_expression (expression) of GluR2 in synapses associated with opiate and withdrawal
1) Confidence 0.49 Published 2006 Journal Life Sci. Section Abstract Doc Link 16616767 Disease Relevance 0 Pain Relevance 1.27
Metabotropic group II receptors (mGluR2 and mGluR3) also modulate pain transmission. mGluR2 is located in sensory neurones and presynaptic nerve terminals whereas mGluR3 is found all over the brain. mGluR3 can be selectively increased in the spinal dorsal horn neurones after peripheral UV injury [94]. mGluR2/3 receptor activation appears necessary to reduce nerve terminal excitability and to modulate pain transmission since treatment with the agonist L-acetyl carnitine reduced inflammatory hyperalgesia and mechanical allodynia and increased the expression of mGluR2/3.
Positive_regulation (increased) of Gene_expression (expression) of mGluR2 in spinal associated with pain, hyperalgesia, allodynia, inflammation, spinal dorsal horn, injury and agonist
2) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.27 Pain Relevance 1.35

General Comments

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