INT13501

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 65
Total Number 67
Disease Relevance 23.76
Pain Relevance 35.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
brain 6
nucleus accumbens 2
neurons 2
putamen 2
caudate nucleus 1
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 783 100.00 Very High Very High Very High
antagonist 137 100.00 Very High Very High Very High
Opioid 130 100.00 Very High Very High Very High
dopamine receptor 91 100.00 Very High Very High Very High
imagery 58 100.00 Very High Very High Very High
gABA 51 100.00 Very High Very High Very High
adenocard 137 99.98 Very High Very High Very High
agonist 150 99.96 Very High Very High Very High
Serotonin 48 99.92 Very High Very High Very High
anesthesia 13 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Facial Pain 4 99.84 Very High Very High Very High
Lifespan 4 99.60 Very High Very High Very High
Akathisia 9 99.58 Very High Very High Very High
Headache 26 99.48 Very High Very High Very High
Alcohol Addiction 165 99.40 Very High Very High Very High
Opiate Addiction 105 99.16 Very High Very High Very High
Disease 158 98.72 Very High Very High Very High
Recurrence 9 98.52 Very High Very High Very High
Cancer 20 98.44 Very High Very High Very High
Targeted Disruption 91 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to their ability to interact with several other G protein-coupled receptors, including CB1, A2a, and D3 receptors (see Franco et al., 2008), D1R and D2R can interact with each other and can be found in the same protein complexes as demonstrated by co-immunoprecipitation from rat striatal extracts (Lee et al., 2004).
D2R Binding (interact) of
1) Confidence 0.48 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.11
Another study using PET and F18-Methylspiroperidol found decreased dopamine D2 receptor binding during cocaine withdrawal and also a separate study using PET and F-18-Dopa discovered low dopaminergic brain activity.
dopamine D2 receptor Binding (binding) of in brain associated with dopamine, withdrawal and cocaine
2) Confidence 0.47 Published 1994 Journal Addiction Section Abstract Doc Link 7841859 Disease Relevance 0.17 Pain Relevance 0.61
In receptor binding test, (+)-ketamine showed a higher affinity for NMDA receptor than that of (+/-)-ketamine, while (+)-ketamine and (+/-)-ketamine showed no affinity for dopamine D2 and serotonin 5-HT2 receptor.
dopamine D2 Neg (no) Binding (affinity) of associated with dopamine, ketamine, nmda receptor and serotonin
3) Confidence 0.47 Published 2006 Journal Life Sci. Section Abstract Doc Link 16289139 Disease Relevance 0 Pain Relevance 1.37
The effects of anesthesia on dopamine D2 receptor binding in the rhesus monkey brain were examined using positron emission tomography.
dopamine D2 receptor Binding (binding) of in brain associated with dopamine, anesthesia and positron emission tomography
4) Confidence 0.47 Published 1995 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 8962684 Disease Relevance 0 Pain Relevance 0.47
Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anesthetics in rhesus monkey brain.
D2 receptor Binding (binding) of in brain
5) Confidence 0.47 Published 1995 Journal J. Neural Transm. Gen. Sect. Section Title Doc Link 8962684 Disease Relevance 0 Pain Relevance 0.48
Iron status may play a pivotal role in the pathophysiology and development of acute akathisia due to the possible interaction of iron with the D2 receptor, but practical clinical significance of this is not yet clear.
D2 receptor Binding (interaction) of associated with akathisia
6) Confidence 0.47 Published 1994 Journal Pharmacopsychiatry Section Abstract Doc Link 7972345 Disease Relevance 0.87 Pain Relevance 0.25
The same effects were produced by the direct injection of dopamine or its agonists into the dorsomedial part of caudate nucleus ipsilateral to the lesion, where spiroperidol binding to the D2 receptor was increased in the affinity.
D2 receptor Binding (binding) of in caudate nucleus associated with dopamine and agonist
7) Confidence 0.47 Published 1987 Journal Eur. Neurol. Section Abstract Doc Link 2953603 Disease Relevance 0.50 Pain Relevance 0.35
There was no difference in dopamine D1 receptor binding, whereas dopamine D2 receptor binding was significantly lower in the hippocampus of deficient animals.
dopamine D2 receptor Binding (binding) of in hippocampus associated with dopamine and hippocampus
8) Confidence 0.46 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11919654 Disease Relevance 0 Pain Relevance 0.65
Moreover, dopamine D1 and D2 receptor binding was measured.
D2 receptor Binding (binding) of associated with dopamine
9) Confidence 0.46 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11919654 Disease Relevance 0 Pain Relevance 0.57
Rats who undergo endurance training show increased
   D2 receptor binding over the lifespan compared to control animals, suggesting that endurance
   training provides some protection from age related loss of D2 receptor functioning 97. 
D2 Binding (binding) of associated with lifespan
10) Confidence 0.41 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.51 Pain Relevance 0.20
Interaction of the dopamine D2 receptor agonist quinpirole with sympathetic vasomotor tone and the central action of rilmenidine in conscious rabbits.
D2 receptor Binding (Interaction) of in sympathetic associated with dopamine and agonist
11) Confidence 0.41 Published 1998 Journal J. Auton. Nerv. Syst. Section Title Doc Link 9851568 Disease Relevance 0.20 Pain Relevance 0.31
However, associations between the DRD2 A1 allele and cannabis use disorders have not been published.
DRD2 Binding (associations) of associated with cannabis
12) Confidence 0.37 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.45 Pain Relevance 0.62
Male-limited associations of the DRD2 A1 allele with alcohol dependence [26] and tobacco smoking [27] have been reported previously.
DRD2 Binding (associations) of associated with addiction, nicotine addiction and alcohol
13) Confidence 0.37 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.40 Pain Relevance 0.50
A critical issue for the future will be to clearly identify in which neurons this interaction between D1R and D2R occurs in vivo.


D2R Binding (interaction) of in neurons
14) Confidence 0.37 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.08 Pain Relevance 0.20
There was a reduction of the dopamine D2 receptor binding potential in all patients compared to age-matched controls.
dopamine D2 receptor Binding (binding) of associated with dopamine
15) Confidence 0.37 Published 1994 Journal Cephalalgia Section Abstract Doc Link 7954746 Disease Relevance 0.35 Pain Relevance 0.40
To test the relationship between response variability and dopaminergic deficiency, we embarked on a study that examined associations between dopamine D2receptor variants and T.O.V.A. scores (including response variability), as well as a measure of brain electrical activity, the P300 event related brain potential (Noble et al 1994).
dopamine D2receptor Spec (examined) Binding (associations) of in brain associated with dopamine
16) Confidence 0.36 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.94 Pain Relevance 0.09
PURPOSE: The dopamine D(2) receptor (D2R) is important in the mediation of addiction. [(123)I]iodobenzamide (IBZM), a SPECT ligand for the D2R, has been used for in vivo studies of D2R availability in humans, monkeys, and rats.
D2R Binding (ligand) of associated with addiction and dopamine
17) Confidence 0.36 Published 2008 Journal Eur. J. Nucl. Med. Mol. Imaging Section Abstract Doc Link 18425511 Disease Relevance 0 Pain Relevance 0.26
A logistic regression analysis showed an interaction between DRD2 alleles and gender (odds ratio = 1.77, 95% CI 1.15–2.70).


DRD2 Binding (interaction) of
18) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Abstract Doc Link PMC1892032 Disease Relevance 0.24 Pain Relevance 0.31
Allelic and genotypic associations of DRD2 TaqI A polymorphism with heroin dependence in Spanish subjects: a case control study

Background

DRD2 TaqI Binding (associations) of associated with addiction and opiate addiction
19) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Title Doc Link PMC1892032 Disease Relevance 0.27 Pain Relevance 0.35
Thus, a role of alpha 2-adrenoceptors and D2-dopamine receptors is postulated in the antinociceptive action of B-HT 920.
D2-dopamine Binding (role) of associated with dopamine receptor and antinociceptive
20) Confidence 0.36 Published 1991 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1672900 Disease Relevance 0.10 Pain Relevance 0.88

General Comments

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