INT135016

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.33
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a5) cytoplasmic membrane-bounded vesicle (Slc17a5) plasma membrane (Slc17a5)
transmembrane transport (Slc17a5) lysosome (Slc17a5)
Anatomy Link Frequency
plasma 2
hepatocyte 2
liver 2
Slc17a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 236 100.00 Very High Very High Very High
aspirin 3 92.72 High High
Inflammation 50 91.80 High High
Analgesic 9 91.56 High High
tail-flick 1 79.48 Quite High
Pain 5 77.88 Quite High
Pain management 6 64.56 Quite High
Bile 1 25.04 Quite Low
nociceptor 1 25.00 Low Low
alcohol 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 28 99.60 Very High Very High Very High
Injury 9 98.36 Very High Very High Very High
Stress 31 96.68 Very High Very High Very High
Malaria 45 96.12 Very High Very High Very High
Necrosis 33 93.80 High High
INFLAMMATION 52 91.80 High High
Overdose 3 90.12 High High
Nephrotoxicity 4 89.60 High High
Toxicity 109 88.40 High High
Gastrointestinal Stromal Tumor 12 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant elevation (p<0.001) of the levels of AST and ALT was observed in mice toxicated with APAP.
Positive_regulation (elevation) of Gene_expression (levels) of AST associated with paracetamol
1) Confidence 0.55 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19109935 Disease Relevance 0.68 Pain Relevance 0.70
On the other hand, APAP induced increases in plasma AST and ALT levels in the highest dose group only, and the DNA damage in the liver increased at the same dose.
Positive_regulation (increases) of Gene_expression (levels) of AST in plasma associated with paracetamol
2) Confidence 0.44 Published 2008 Journal J Toxicol Sci Section Abstract Doc Link 19043273 Disease Relevance 0.09 Pain Relevance 0.38
The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCl(4) treated animals (p > 0.05).
Positive_regulation (increased) of Gene_expression (levels) of AST
3) Confidence 0.36 Published 2006 Journal Phytother Res Section Abstract Doc Link 16619345 Disease Relevance 0.18 Pain Relevance 0.65
However, at higher doses of sunitinib in group D, both the AST and ALT levels were significantly increased (Figure 1).
Positive_regulation (increased) of Gene_expression (levels) of AST
4) Confidence 0.28 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.42 Pain Relevance 0.53
SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-alpha but also APAP-induced GSH depletion and MDA accumulation.
Positive_regulation (increases) of Gene_expression (depletion) of AST associated with paracetamol and hepatotoxicity
5) Confidence 0.27 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.66 Pain Relevance 0.98
In contrast, after sunitinib was administered at escalating doses, the serum AST and ALT levels were only slightly elevated and mild liver damage with slight vascular congestion and signs of hepatocyte regeneration were found (Figure 3).
Positive_regulation (elevated) of Gene_expression (levels) of serum AST in hepatocyte associated with hepatotoxicity
6) Confidence 0.25 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.55 Pain Relevance 0.51
Set IV A results (Table 10) clearly depict an increase in serum AST and ALT levels indicating hepatotoxicity to a mild extent.
Positive_regulation (increase) of Gene_expression (levels) of AST associated with hepatotoxicity
7) Confidence 0.22 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2661047 Disease Relevance 0.44 Pain Relevance 0
This interpretation is consistent with elevated serum ALT and AST levels noted in P.berghei-infected DBA-2 mice [7], an indication that enhanced oxidative stress during malaria may have caused liver cell injury.
Positive_regulation (elevated) of Gene_expression (levels) of AST in liver associated with malaria, stress and injury
8) Confidence 0.06 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.31 Pain Relevance 0

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