INT135022

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Context Info
Confidence 0.76
First Reported 2004
Last Reported 2010
Negated 10
Speculated 0
Reported most in Body
Documents 79
Total Number 79
Disease Relevance 36.37
Pain Relevance 10.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd14) plasma membrane (Cd14)
Anatomy Link Frequency
macrophages 7
monocytes 5
liver 4
brain 2
endometrium 2
Cd14 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1529 99.92 Very High Very High Very High
Inflammatory response 419 99.84 Very High Very High Very High
agonist 109 99.36 Very High Very High Very High
cytokine 1266 98.74 Very High Very High Very High
Bile 5 98.46 Very High Very High Very High
chemokine 182 97.84 Very High Very High Very High
antagonist 46 93.16 High High
Crohn's disease 13 92.48 High High
Intracerebroventricular 132 91.80 High High
tolerance 316 89.24 High High
Disease Link Frequency Relevance Heat
Systemic Sclerosis 34 100.00 Very High Very High Very High
INFLAMMATION 1762 99.92 Very High Very High Very High
Brain Tumor 47 99.84 Very High Very High Very High
Disease 701 99.58 Very High Very High Very High
Infection 624 99.54 Very High Very High Very High
Adhesions 37 99.28 Very High Very High Very High
Parkinson's Disease 4 99.22 Very High Very High Very High
Lyme Disease 273 98.98 Very High Very High Very High
Hypersensitivity 26 98.92 Very High Very High Very High
Targeted Disruption 152 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alveolar macrophages, which express both CD14 and TLR4 [22] and are major producers of TNF, may not require CD14 to respond to low dose R-LPS as previously found with peritoneal macrophages [14].
Gene_expression (express) of CD14 in Alveolar macrophages
1) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.07 Pain Relevance 0.18
CD14, a 55-kDa glycoprotein predominantly expressed on the surface of myeloid cells via a glycosylphosphatidyl anchor, associates with the TLR4/MD-2 complex and transfer LPS monomers to TLR4/MD-2 [8].
Gene_expression (expressed) of CD14 in myeloid cells
2) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.22 Pain Relevance 0.20
CD14 also exists in a soluble form (sCD14), which is able to mediate LPS-activation of cells devoid of membrane CD14 expression, such as epithelial and endothelial cells [9].
Gene_expression (expression) of CD14 in endothelial cells
3) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.14 Pain Relevance 0.14
Macrophages lacking CD14 secreted equal amounts of TNF as macrophages expressing CD14 upon stimulation with R-LPS, but failed to secrete TNF in response to S-LPS which was reversed by addition of sCD14 [14].
Gene_expression (expressing) of CD14 in Macrophages
4) Confidence 0.76 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.35 Pain Relevance 0.09
This enhanced transcriptional activity has been associated with higher concentrations of soluble CD14 and enhanced CD14 expression on the membrane of the monocytes [12].
Gene_expression (expression) of CD14 in monocytes
5) Confidence 0.74 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1634873 Disease Relevance 0.63 Pain Relevance 0.27
This enhanced transcriptional activity has been associated with higher concentrations of soluble CD14 and enhanced CD14 expression on the membrane of the monocytes [12].
Gene_expression (expression) of CD14 in monocytes
6) Confidence 0.74 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1634873 Disease Relevance 0.63 Pain Relevance 0.27
CD14 is a gene preferentially expressed on monocytes/macrophages generating a surface protein.
Gene_expression (expressed) of CD14 in macrophages
7) Confidence 0.74 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1634873 Disease Relevance 0.76 Pain Relevance 0.28
Macrophages express CD14 which partners with Toll-like receptor 2/1 to recognize bacterial lipoproteins such as those of Borrelia burgdorferi, the causative agent of Lyme disease.
Gene_expression (express) of CD14 in Macrophages associated with lyme disease
8) Confidence 0.72 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2781632 Disease Relevance 0.81 Pain Relevance 0.34
expressing CD14 and TLR2 and those deficient for individual or both loci were co-incubated with spirochetes and TNF-?
Gene_expression (expressing) of CD14
9) Confidence 0.72 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.07 Pain Relevance 0.13
CD14, a GPI-anchored protein expressed by macrophages (M?)
Gene_expression (expressed) of CD14 in macrophages
10) Confidence 0.72 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.58 Pain Relevance 0.23
In the absence of CD14, TNF-?
Neg (absence) Gene_expression (absence) of CD14
11) Confidence 0.72 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.06 Pain Relevance 0.14
which lack CD14 than those expressing CD14.
Gene_expression (expressing) of CD14
12) Confidence 0.72 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0
However, we and others have repeatedly shown that primary neurons enriched in cell culture do not respond to LPS [10,11,22-24]; indeed, neurons do not express CD14 and TLR-4 in vivo [25,26].
Neg (not) Gene_expression (express) of CD14 in neurons
13) Confidence 0.71 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0 Pain Relevance 0.11
While this limits interpretation of data from some mice, such as p50 -/- and EP2-/- mice because these proteins are expressed by both neurons and glia [27-32], it does not influence interpretation of data from CD14 -/- mice because CD14 expression in vivo is restricted to microglia among parencymal cells in brain [25,26].
Gene_expression (expression) of CD14 in neurons
14) Confidence 0.71 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.06 Pain Relevance 0.13
Moreover, we show that sCD14 can partially reproduce these differential roles of CD14.
Gene_expression (reproduce) of CD14
15) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.28 Pain Relevance 0.13
Knock down of CD14 was achieved using a pRS-shGFP lentiviral expression vector (OriGene Technologies, Rockville, MD) to transduce either a CD14 shRNA or a scrambled control shRNA into CD14+/+ M?.
Gene_expression (expression) of CD14 associated with targeted disruption
16) Confidence 0.63 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.10 Pain Relevance 0
Herein, this paradigm is challenged by demonstrating that recognition of live Borrelia burgdorferi not only triggers an inflammatory response in the absence of CD14, but one that is, in part, a consequence of altered PI3K/AKT/p38-MAPK signaling and impaired negative regulation of TLR2.
Neg (absence) Gene_expression (absence) of CD14 associated with lyme disease and inflammatory response
17) Confidence 0.63 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2781632 Disease Relevance 0.43 Pain Relevance 0.27
Mice deficient for CD14 and their M?
Gene_expression (deficient) of CD14
18) Confidence 0.63 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.60 Pain Relevance 0.26
CD14, a GPI-anchored protein expressed by macrophages (M?)
Gene_expression (expressed) of CD14 in macrophages
19) Confidence 0.63 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.58 Pain Relevance 0.23
produced by CD14?
Gene_expression (produced) of CD14
20) Confidence 0.63 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.31 Pain Relevance 0.22

General Comments

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