INT135027

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.84
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
liver 2
MKGS 2
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 59 99.74 Very High Very High Very High
Analgesic 7 94.24 High High
Antinociceptive 3 84.40 Quite High
carrageenan induced 1 66.12 Quite High
narcan 10 56.48 Quite High
Opioid 9 50.40 Quite High
Pain 3 49.48 Quite Low
Morphine 7 37.84 Quite Low
Serotonin 2 16.00 Low Low
bradykinin 1 9.20 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 61 99.74 Very High Very High Very High
Necrosis 5 97.80 Very High Very High Very High
Pressure And Volume Under Development 30 97.32 Very High Very High Very High
Cancer 8 91.88 High High
Gastritis 1 89.20 High High
Injury 7 88.00 High High
Pain 1 49.48 Quite Low
Cramps 1 49.24 Quite Low
Urological Neuroanatomy 12 5.00 Very Low Very Low Very Low
Peritonitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MKGS also affected the levels of IL-1beta, TNF-alpha and NO induced by lambda-carrageenan.
Regulation (affected) of Positive_regulation (induced) of TNF-alpha in MKGS
1) Confidence 0.38 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503470 Disease Relevance 1.04 Pain Relevance 0.58
The increase in TNF-alpha, LBP and CD14 mRNA expression in mouse liver after BCG and LPS injection was significantly decreased by paeoniflorin (100 mg/kg) and was changed by paeoniflorin (25, 50 mg/kg) at different time-point.
Regulation (changed) of Positive_regulation (increase) of TNF-alpha in liver
2) Confidence 0.29 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16620297 Disease Relevance 0.98 Pain Relevance 0.08
It has been recently shown that lupeol acetate presents an anti-inflammatory activity by regulating TNF-alpha and IL-2 specific mRNA, besides upregulating the synthesis of IL-10 mRNA [31].
Regulation (regulating) of Positive_regulation (upregulating) of TNF-alpha associated with inflammation
3) Confidence 0.16 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 0.82 Pain Relevance 0.40

General Comments

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