INT135028

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 34
Disease Relevance 16.19
Pain Relevance 5.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd14) plasma membrane (Cd14)
Anatomy Link Frequency
macrophages 4
microglia 4
lung 3
plasma 1
liver 1
Cd14 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 720 100.00 Very High Very High Very High
cytokine 419 99.46 Very High Very High Very High
Inflammatory response 149 99.36 Very High Very High Very High
agonist 73 96.72 Very High Very High Very High
tolerance 45 96.48 Very High Very High Very High
Pyramidal cell 27 96.36 Very High Very High Very High
Paracetamol 4 93.92 High High
chemokine 95 93.60 High High
Spinal cord 20 92.16 High High
Neuropathic pain 10 91.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 671 100.00 Very High Very High Very High
Infection 278 100.00 Very High Very High Very High
Mycobacterial Infection 151 100.00 Very High Very High Very High
Apoptosis 20 99.68 Very High Very High Very High
Diabetes Mellitus 160 99.52 Very High Very High Very High
Lyme Disease 39 99.40 Very High Very High Very High
Neurodegenerative Disease 26 98.62 Very High Very High Very High
Drug Induced Neurotoxicity 9 98.24 Very High Very High Very High
Necrosis 36 97.80 Very High Very High Very High
Disease 370 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To exclude the possibility that the increase in alveolar sCD14 levels resulted from leakage of serum proteins, total protein concentrations in BALF of LPS-treated WT mice were assessed.
Positive_regulation (increase) of sCD14
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.33 Pain Relevance 0.17
These data indicate that the TLR4/MD-2 complex requires CD14 for the activation of MyD88-dependent signaling by S-LPS, but not by R-LPS.
Positive_regulation (requires) of CD14
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.40 Pain Relevance 0.11
This possibility is supported by the lack of an effect of (s)CD14 on LIX release after high dose LPS administration, considering that respiratory epithelial cells are important for both PMN influx and LIX secretion [20], [24].
Positive_regulation (effect) of CD14 in respiratory
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.27 Pain Relevance 0.13
In the present study, we found at low doses that R-LPS (but not S-LPS) induced TNF secretion in the lung in a CD14-independent manner, whereas PMN recruitment into the lung was induced by these LPS chemotypes in a CD14-dependent manner.
Positive_regulation (induced) of CD14 in lung
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.27 Pain Relevance 0.21
The requirement of CD14 in S-LPS-induced inflammatory responses is in line with previous in vitro and in vivo studies with cytokine release as read-out [12], [14].
Positive_regulation (requirement) of CD14 associated with inflammatory response and cytokine
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.16 Pain Relevance 0.21
However, high concentrations of sCD14 may interfere with LPS-induced activation of CD14-expressing cells like macrophages [10], [11].
Positive_regulation (activation) of CD14-expressing in macrophages
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.18 Pain Relevance 0.13
This enhanced transcriptional activity has been associated with higher concentrations of soluble CD14 and enhanced CD14 expression on the membrane of the monocytes [12].
Positive_regulation (concentrations) of CD14 in monocytes
7) Confidence 0.48 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1634873 Disease Relevance 0.63 Pain Relevance 0.26
However, in contrast to live bacteria, an equivalent number of lysed spirochetes are approximately 100-fold less stimulatory and are primarily dependent upon CD14 to initiate an inflammatory response from M?
Positive_regulation (dependent) of CD14 associated with inflammatory response
8) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.39 Pain Relevance 0.26
The biochemical changes of brain microglia are supported by a recent study that showed several microglial markers such as OX-42, TLR4 and CD14 were upregulated following intraplantar injection of complete Freunds adjuvant (CFA) [34].
Positive_regulation (upregulated) of CD14 in microglia
9) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2374773 Disease Relevance 0.80 Pain Relevance 0.69
Published data on the contribution of CD14 to R-LPS- induced cytokine release are inconsistent: CD14 has been reported to be irrelevant for R-LPS-induced TNF production [14], whereas other investigations found that CD14 augmented R-LPS-induced cytokine secretion by macrophages [12], [21] as well as plasma TNF levels triggered by intravenous R-LPS [12].
Positive_regulation (irrelevant) of CD14 in macrophages associated with cytokine
10) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.15 Pain Relevance 0.22
This same response can occur in response to endogenous ligands that also activate the CD14/TLR-4 pathway [2,3].
Positive_regulation (activate) of CD14
11) Confidence 0.46 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.76 Pain Relevance 0.16
TLR-2, like TLR-4, is one of the plasma membrane TLRs that may be activated by LPS and that also uses CD14 as a co-receptor.
Positive_regulation (uses) of CD14 in plasma
12) Confidence 0.46 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 0.10 Pain Relevance 0.38
Relevant to a broader range of neurodegenerative diseases, novel peptides and neoantigens exposed by apoptotic cells [9] also activate CD14-dependent innate immune response in macrophages.
Positive_regulation (activate) of CD14 in macrophages associated with apoptosis and neurodegenerative disease
13) Confidence 0.46 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527876 Disease Relevance 1.12 Pain Relevance 0.06
, activation of CD14?
Positive_regulation (activation) of CD14
14) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.16 Pain Relevance 0.17
Using a mouse model of Lyme disease, we show that B. burgdorferi-activated CD14?
Positive_regulation (activated) of CD14 associated with lyme disease
15) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.47 Pain Relevance 0.38
Strikingly, in response to high dose LPS, PMN recruitment and TNF release in the lung were exaggerated in CD14KO mice relative to WT mice.
Positive_regulation (exaggerated) of CD14KO in lung
16) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.17 Pain Relevance 0.13
However, high concentrations of sCD14 may interfere with LPS-induced activation of CD14-expressing cells like macrophages [10], [11].
Positive_regulation (concentrations) of sCD14 in macrophages
17) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.18 Pain Relevance 0.14
This was accompanied by significantly reduced BALF TNF levels in S-LPS-treated CD14KO mice (P<0.01, Fig. 2E, F), but increased TNF levels in R-LPS-treated CD14KO mice (P<0.001, Fig. 3E).
Positive_regulation (increased) of CD14KO
18) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.41 Pain Relevance 0.18
Whereas, the latter route functions through more complex pathways, such as immune recognition of bacterial envelope components, activation of Toll-like receptors, CD14, mannose receptors, etc. [4].
Positive_regulation (activation) of CD14
19) Confidence 0.36 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0.34 Pain Relevance 0.22
A second group of DAMPs requires only CD14 as an accessory molecule and these are surfactant protein A and D and lactoferrin [78–80].
Positive_regulation (requires) of CD14
20) Confidence 0.34 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0 Pain Relevance 0.05

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