INT135039

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 5.66
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dendritic cells 2
testes 1
Cd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 6 100.00 Very High Very High Very High
Pain 20 95.08 Very High Very High Very High
Inflammation 16 84.48 Quite High
Enkephalin 2 82.56 Quite High
Dynorphin 2 81.36 Quite High
Cholecystokinin 2 70.88 Quite High
Hippocampus 2 27.36 Quite Low
chemokine 4 26.08 Quite Low
antagonist 30 15.52 Low Low
agonist 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 202 100.00 Very High Very High Very High
Sprains And Strains 202 99.00 Very High Very High Very High
Anxiety Disorder 11 96.20 Very High Very High Very High
Disease 33 95.44 Very High Very High Very High
Pain 19 95.08 Very High Very High Very High
Neurodegenerative Disease 1 92.16 High High
Wound Healing 6 91.28 High High
Creutzfeldt Jakob Disease 1 90.88 High High
Injury 156 90.32 High High
Apoptosis 82 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using in situ hybridization and immunohistochemistry, we have studied changes in the expression of neuropeptides, acetylcholinesterase and tyrosine hydroxylase in CD1 and FVB wild-type mouse strains, as well as in PrP(C) null mice and in mice overexpressing PrP(C) following intracerebral inoculation with RML or Me7 prions.
Gene_expression (expression) of CD1 associated with neuropeptide and sprains and strains
1) Confidence 0.60 Published 2007 Journal Neurobiol. Aging Section Abstract Doc Link 16621165 Disease Relevance 0.28 Pain Relevance 0.43
Adult baseline PWL was significantly decreased in CD1 mice exposed to CFA on PND 1 and 14 as compared to their saline treated counterparts.
Gene_expression (exposed) of CD1
2) Confidence 0.55 Published 2009 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 19665540 Disease Relevance 1.38 Pain Relevance 0.62
However, in a 70-87% CD1 background a more detailed evaluation revealed an obvious craniofacial phenotype in Gtf2i?
Gene_expression (background) of CD1
3) Confidence 0.44 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2865459 Disease Relevance 0.09 Pain Relevance 0
-expressing mouse line on a CD1 background, whose gastric mucosa appears normal.
Gene_expression (expressing) of CD1
4) Confidence 0.29 Published 2006 Journal BMC Gastroenterol Section Abstract Doc Link PMC1552080 Disease Relevance 1.09 Pain Relevance 0
-expressing TG male mice and CD1 wild type (WT) male mice at ages 6 to 8 weeks.
Gene_expression (expressing) of CD1 associated with targeted disruption
5) Confidence 0.29 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1552080 Disease Relevance 1.10 Pain Relevance 0
This finding raises the hypothesis that LPA can regulate antigen presentation by dendritic cells through the expression of CD1 molecules.
Gene_expression (expression) of CD1 in dendritic cells
6) Confidence 0.20 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.15 Pain Relevance 0
CD1 expression in immature dendritic cells was under the transcriptional control of PPAR?.
Gene_expression (expression) of CD1 in dendritic cells
7) Confidence 0.20 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.27 Pain Relevance 0
There were practically no TEBs in the former, whereas a few TEBs were present in the CD-1 females 10 days after ovariectomy.
Gene_expression (present) of CD-1
8) Confidence 0.17 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.26 Pain Relevance 0
Specifically, CD-1 males were shown to be E2-resistant when compared with C57Bl6 mice regarding effects on testes weight and spermatogenesis (Spearow et al. 1999).
Gene_expression (males) of CD-1 in testes
9) Confidence 0.17 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.61 Pain Relevance 0
Consistent with this concept, previous studies of CD-1 mice exposed perinatally to BPA revealed an increased number of TEBs at puberty and terminal ends in adulthood (Markey et al. 2001a; Munoz de Toro et al. 2005).
Gene_expression (exposed) of CD-1
10) Confidence 0.17 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.39 Pain Relevance 0
allele would take place through outcrossing onto the CD-1 background.
Gene_expression (background) of CD-1
11) Confidence 0.11 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.05 Pain Relevance 0
When animals of this “N1 generation” were again outcrossed against CD-1, 18% of surviving progeny (N2) carried the mutant allele.
Gene_expression (outcrossed) of CD-1
12) Confidence 0.10 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0 Pain Relevance 0

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