INT13504

Context Info Confidence 0.58 First Reported 1981 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 19 Total Number 19 Disease Relevance 2.07 Pain Relevance 4.50

extracellular region (MUC7)

Anatomy Link Frequency vesicles 2 plasma 1 uterine smooth muscle 1 brain 1 external 1 MUC7 (Homo sapiens)

Pain Link Frequency Relevance Heat tetrodotoxin 5 99.90 opiate 9 99.60 narcan 7 99.46 Pyramidal cell 8 99.24 adenocard 23 99.06 Opioid 4 98.20 lidocaine 5 98.04 anesthesia 4 97.64 Calcium channel 1 96.86 antagonist 11 95.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 8 99.80 Heart Rate Under Development 4 96.48 Death 15 91.48 Cognitive Disorder 3 91.20 Arrhythmias 2 Under Development 1 86.52 Ganglion Cysts 1 86.04 Shock 4 84.20 Vibrio Infection 1 82.72 Nervous System Injury 6 81.84 Dysmenorrhea 1 81.08

Sentences Mentioned In

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Protein

Mutation

Event

Anatomy

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Aged and young rats on a diet that elevated plasma Mg2+ exhibited stronger frequency potentiation under urethane anesthesia, and showed improved maze reversal learning.

Positive_regulation (elevated) of Mg2 in plasma associated with anesthesia

1) Confidence 0.58 Published 1984 Journal Brain Res. Section Abstract Doc Link 6097334 Disease Relevance 0 Pain Relevance 0.10

Sidedness of synaptic plasma membrane vesicles isolated from brain synaptosomes has been assessed by two distinct experimental approaches: first, analysis of (Na+ + K+)-ATPase, Mg2+-ATPase, and (Ca2+ + Mg2+)-ATPase activities before and after permeabilization of vesicles; second, analysis of Ca2+ fluxes via the Na+/Ca2+ exchanger, before and after modification of an imposed Na+ gradient by penetrating or nonpenetrating Na+ channel-modifying drugs. 0.05% saponin, which completely permeabilizes the vesicles, increases digitoxigenin-sensitive (Na+ + K+)-ATPase, basal Mg2+-ATPase, and (Ca2+ + Mg2+)-ATPase activities by 51.0, 47.4, and 83.6%, respectively.

Positive_regulation (increases) of Mg2 in vesicles

2) Confidence 0.45 Published 1986 Journal Biochim. Biophys. Acta Section Abstract Doc Link 3006769 Disease Relevance 0 Pain Relevance 0

The responses were reversibly abolished when the concentration of Mg2+ in the bathing solution was elevated to 12 mM.

Positive_regulation (elevated) of Mg2

3) Confidence 0.39 Published 1981 Journal Am. J. Physiol. Section Abstract Doc Link 7246744 Disease Relevance 0.25 Pain Relevance 0.27

Elevated extracellular Mg2+ specifically improves frequency potentiation in hippocampal slices, and chronic alterations in plasma Mg2+ can increase brain Mg2+ in intact animals.

Positive_regulation (increase) of Mg2 in brain

4) Confidence 0.39 Published 1984 Journal Brain Res. Section Abstract Doc Link 6097334 Disease Relevance 0 Pain Relevance 0.09

Therefore, the lack of Mg2+ modulation of N-methyl-D-aspartate-evoked adenosine release was not due to depolarization-induced alleviation of the Mg2+ block in the slices.

Positive_regulation (alleviation) of Mg2 associated with adenocard

5) Confidence 0.36 Published 1990 Journal Neuroscience Section Abstract Doc Link 1982346 Disease Relevance 0 Pain Relevance 0.67

It is concluded that there exists an additional gating process at the inner cell surface becoming active only at increased concentrations of intracellular free Mg2+ regulating the exit of Mg2+ by the efflux system.

Positive_regulation (increased) of Mg2

6) Confidence 0.24 Published 1984 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 6422934 Disease Relevance 0 Pain Relevance 0.09

The increase of Ca2+ and Mg2+ permeability by dibucaine and by tetracaine is found at concentrations of these drugs that do not produce a noticeable inhibition of the (Ca2+ + Mg2+)-ATPase activity of sarcoplasmic reticulum vesicles.

Positive_regulation (increase) of Mg2 in vesicles

7) Confidence 0.23 Published 1987 Journal Biochim. Biophys. Acta Section Abstract Doc Link 3620467 Disease Relevance 0.06 Pain Relevance 0.25

In the nonischemic dog heart, marked increases of serum Mg2+ progressively prolonged the A-H, H-V, and QR S intervals, the ventricular effective refractory period, and the sinus cycle length, while the arterial blood pressure fell.

Positive_regulation (increases) of Mg2 in blood

8) Confidence 0.10 Published 1988 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 3154638 Disease Relevance 0.45 Pain Relevance 0

However, increased Mg2+ concentration did not change the tonic blocks but increased the phasic blocks.

Positive_regulation (increased) of Mg2

9) Confidence 0.10 Published 2003 Journal Pol J Pharmacol Section Abstract Doc Link 12856822 Disease Relevance 0 Pain Relevance 0.43

The analogs used in this study were derivatives of 7-glycine oxytocin, which is about 10 times more active when the Mg2+ concentration in the uterine smooth muscle bath is increased from 0 to 0.5 mM.

Positive_regulation (increased) of Mg2 in uterine smooth muscle

10) Confidence 0.07 Published 1986 Journal Endocrinology Section Abstract Doc Link 3019637 Disease Relevance 0.08 Pain Relevance 0.19

Both spontaneous and stimulus-evoked EPSPs were abolished or suppressed by addition of hexamethonium, tetrodotoxin, or elevation of Mg2+ and reduction of Ca2+ in the bathing medium.

Positive_regulation (elevation) of Mg2 associated with tetrodotoxin

11) Confidence 0.04 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2900605 Disease Relevance 0 Pain Relevance 0.10

Pretreatment with the calcium channel blockers nimodipine (1 mg/kg s.c.), diltiazem (10 mg/kg s.c.) and verapamil (2.5 mg/kg s.c.) potentiated the hypothermic effect of U-50,488H as well as the stimulation of Ca2+/Mg2+ ATPase in hypothalamus.

Positive_regulation (stimulation) of Mg2 in hypothalamus associated with calcium channel

12) Confidence 0.03 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3028838 Disease Relevance 0.07 Pain Relevance 0.42

It is obvious that the neuroprotective effect of Mg2+ is already established at P14 immediately after the period of treatment (Table 1,2,3 and Figures 1a and 1b).

Positive_regulation (effect) of Mg2

13) Confidence 0.02 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC522819 Disease Relevance 0.22 Pain Relevance 0.04

In non-infused conscious rats, the excretion of all ions was higher in diabetics, but the increased output of Ca2+ and Mg2+ was far greater than that of other electrolytes.

Positive_regulation (increased) of Mg2 associated with diabetes mellitus

14) Confidence 0.02 Published 1990 Journal Acta Endocrinol. Section Abstract Doc Link 2185603 Disease Relevance 0.64 Pain Relevance 0

Moreover, the opioid stimulation was associated with a significant increase of the affinity of the enzyme for Mg2+ activation and occurred in membranes incubated in a Ca2(+)-free medium.

Positive_regulation (activation) of Mg2 associated with opioid

15) Confidence 0.02 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1673223 Disease Relevance 0.15 Pain Relevance 1.01

Opiates inhibit calmodulin activation of a high-affinity Ca2+-stimulated Mg2+-dependent ATPase in synaptic membranes.

Positive_regulation (activation) of Mg2 associated with opiate

16) Confidence 0.01 Published 1987 Journal Neurochem. Res. Section Title Doc Link 2952897 Disease Relevance 0 Pain Relevance 0.52

In the case of GTP stimulation in Paramecium, activation of Ca2+-dependent Mg2+ and/or Na+ conductances is prolonged to convert AR into continuous ciliary reversals (CCR), presumably due to continued elevation in intraciliary Ca2+.

Positive_regulation (activation) of Mg2 in ciliary

17) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0.09

These Ca2+ oscillations are mirrored in the activation of Ca2+-dependent Mg2+ and/or Na+ conductances which cause sustained, oscillating depolarizations in the presence of sufficient external Mg2+ and/or Na+.

Positive_regulation (activation) of Mg2 in external

18) Confidence 0.01 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0.06 Pain Relevance 0.07

Surprisingly, cortical pyramidal neurons of R6/2 mice at similar ages display increased Mg2+ sensitivity, thus leading to reduced NMDA currents (André et al., 2006).

Positive_regulation (increased) of Mg2 in pyramidal neurons associated with pyramidal cell

19) Confidence 0.01 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.09 Pain Relevance 0.18

General Comments

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