INT13504
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Aged and young rats on a diet that elevated plasma Mg2+ exhibited stronger frequency potentiation under urethane anesthesia, and showed improved maze reversal learning. | |||||||||||||||
| |||||||||||||||
|
Sidedness of synaptic plasma membrane vesicles isolated from brain synaptosomes has been assessed by two distinct experimental approaches: first, analysis of (Na+ + K+)-ATPase, Mg2+-ATPase, and (Ca2+ + Mg2+)-ATPase activities before and after permeabilization of vesicles; second, analysis of Ca2+ fluxes via the Na+/Ca2+ exchanger, before and after modification of an imposed Na+ gradient by penetrating or nonpenetrating Na+ channel-modifying drugs. 0.05% saponin, which completely permeabilizes the vesicles, increases digitoxigenin-sensitive (Na+ + K+)-ATPase, basal Mg2+-ATPase, and (Ca2+ + Mg2+)-ATPase activities by 51.0, 47.4, and 83.6%, respectively. | |||||||||||||||
| |||||||||||||||
|
The responses were reversibly abolished when the concentration of Mg2+ in the bathing solution was elevated to 12 mM. | |||||||||||||||
| |||||||||||||||
|
Elevated extracellular Mg2+ specifically improves frequency potentiation in hippocampal slices, and chronic alterations in plasma Mg2+ can increase brain Mg2+ in intact animals. | |||||||||||||||
| |||||||||||||||
|
Therefore, the lack of Mg2+ modulation of N-methyl-D-aspartate-evoked adenosine release was not due to depolarization-induced alleviation of the Mg2+ block in the slices. | |||||||||||||||
| |||||||||||||||
|
It is concluded that there exists an additional gating process at the inner cell surface becoming active only at increased concentrations of intracellular free Mg2+ regulating the exit of Mg2+ by the efflux system. | |||||||||||||||
| |||||||||||||||
|
The increase of Ca2+ and Mg2+ permeability by dibucaine and by tetracaine is found at concentrations of these drugs that do not produce a noticeable inhibition of the (Ca2+ + Mg2+)-ATPase activity of sarcoplasmic reticulum vesicles. | |||||||||||||||
| |||||||||||||||
|
In the nonischemic dog heart, marked increases of serum Mg2+ progressively prolonged the A-H, H-V, and QR S intervals, the ventricular effective refractory period, and the sinus cycle length, while the arterial blood pressure fell. | |||||||||||||||
| |||||||||||||||
|
However, increased Mg2+ concentration did not change the tonic blocks but increased the phasic blocks. | |||||||||||||||
| |||||||||||||||
|
The analogs used in this study were derivatives of 7-glycine oxytocin, which is about 10 times more active when the Mg2+ concentration in the uterine smooth muscle bath is increased from 0 to 0.5 mM. | |||||||||||||||
| |||||||||||||||
|
Both spontaneous and stimulus-evoked EPSPs were abolished or suppressed by addition of hexamethonium, tetrodotoxin, or elevation of Mg2+ and reduction of Ca2+ in the bathing medium. | |||||||||||||||
| |||||||||||||||
|
Pretreatment with the calcium channel blockers nimodipine (1 mg/kg s.c.), diltiazem (10 mg/kg s.c.) and verapamil (2.5 mg/kg s.c.) potentiated the hypothermic effect of U-50,488H as well as the stimulation of Ca2+/Mg2+ ATPase in hypothalamus. | |||||||||||||||
| |||||||||||||||
|
It is obvious that the neuroprotective effect of Mg2+ is already established at P14 immediately after the period of treatment (Table 1,2,3 and Figures 1a and 1b). | |||||||||||||||
| |||||||||||||||
|
In non-infused conscious rats, the excretion of all ions was higher in diabetics, but the increased output of Ca2+ and Mg2+ was far greater than that of other electrolytes. | |||||||||||||||
| |||||||||||||||
|
Moreover, the opioid stimulation was associated with a significant increase of the affinity of the enzyme for Mg2+ activation and occurred in membranes incubated in a Ca2(+)-free medium. | |||||||||||||||
| |||||||||||||||
|
Opiates inhibit calmodulin activation of a high-affinity Ca2+-stimulated Mg2+-dependent ATPase in synaptic membranes. | |||||||||||||||
| |||||||||||||||
|
In the case of GTP stimulation in Paramecium, activation of Ca2+-dependent Mg2+ and/or Na+ conductances is prolonged to convert AR into continuous ciliary reversals (CCR), presumably due to continued elevation in intraciliary Ca2+. | |||||||||||||||
| |||||||||||||||
|
These Ca2+ oscillations are mirrored in the activation of Ca2+-dependent Mg2+ and/or Na+ conductances which cause sustained, oscillating depolarizations in the presence of sufficient external Mg2+ and/or Na+. | |||||||||||||||
| |||||||||||||||
|
Surprisingly, cortical pyramidal neurons of R6/2 mice at similar ages display increased Mg2+ sensitivity, thus leading to reduced NMDA currents (André et al., 2006). | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.