INT135040

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 30
Total Number 32
Disease Relevance 10.52
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
brainstem 6
brain 2
nasal septum 2
neural 2
hypothalamus 1
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 6 100.00 Very High Very High Very High
Neuronal excitability 12 99.88 Very High Very High Very High
cerebral cortex 5 99.68 Very High Very High Very High
Thalamus 24 96.72 Very High Very High Very High
medulla 48 95.76 Very High Very High Very High
Enkephalin 2 90.16 High High
Dynorphin 2 88.96 High High
tetrodotoxin 12 80.64 Quite High
Cholecystokinin 2 78.48 Quite High
imagery 103 75.92 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 414 100.00 Very High Very High Very High
Infection 235 100.00 Very High Very High Very High
Creutzfeldt Jakob Disease 968 99.36 Very High Very High Very High
Chronic Wasting Disease 15 98.92 Very High Very High Very High
Disease 355 97.92 Very High Very High Very High
Scrapie 285 97.84 Very High Very High Very High
Disease Progression 12 97.04 Very High Very High Very High
Neurodegenerative Disease 65 92.76 High High
Encephalopathy 75 92.04 High High
Viral Infection 4 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we explore the role of PrPc expression in neurotransmission and neural excitability using wild-type, Prnp ?
Regulation (role) of Gene_expression (expression) of PrPc in neural
1) Confidence 0.62 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2763346 Disease Relevance 0.31 Pain Relevance 0.15
This method also lacks desired temporal control of PrPC expression, since once brain cells are infected with lentivirus, it will likely irreversibly suppress PrPC expression in these cells.
Regulation (control) of Gene_expression (expression) of PrPC in brain
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.58 Pain Relevance 0
In the same set of experiments we followed by Western blot analysis the level of total PrPC in non-infected MovS6 cells to determine if GA has any effect on the basal level of PrP expression in MovS6 cells, which could indirectly affect PrPSc accumulation (Figure 2 panel b, bottom).
Regulation (effect) of Gene_expression (expression) of PrP
3) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0 Pain Relevance 0
We demonstrated that EEs are not involved in PrPSc production.
Regulation (involved) of Gene_expression (production) of PrPSc
4) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.08 Pain Relevance 0
By specifically reducing the number of LE by Alix depletion (Figure 4 and Figure S5) we demonstrated that LE are not involved in PrPSc production.
Regulation (involved) of Gene_expression (production) of PrPSc
5) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.05 Pain Relevance 0
Alterations in synaptic NMDAR-mediated currents in PrP-null mice
Regulation (Alterations) of Gene_expression (currents) of PrP
6) Confidence 0.45 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.08 Pain Relevance 0.24
RT-PCR analysis of NMDAR subunit and PrP expression
Regulation (analysis) of Gene_expression (expression) of PrP
7) Confidence 0.45 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
Interestingly, by performing PK assay we observed that while total PrP levels were unchanged, there was ?
Regulation (unchanged) of Gene_expression (levels) of PrP
8) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
In contrast, we observed that in both cell lines U18666A treatment altered the subcellular distribution of PrPC, which became highly enriched (?
Regulation (altered) of Gene_expression (distribution) of PrPC
9) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
Impaired recycling from early endosomes does not affect PrPSc levels
Regulation (affect) of Gene_expression (levels) of PrPSc
10) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.08 Pain Relevance 0
At variance, BASE-infected mice showed primarily diffuse PrP deposition in the cerebral cortex, particularly in the somatosensory region, basal ganglia, thalamus, hypothalamus, brainstem, and cerebellum, accompanied by focal (granular, perivacuolar, and perineuronal) PrP deposits (Figure 1I and 1J).
Regulation (diffuse) of Gene_expression (deposition) of PrP in brainstem associated with medulla, creutzfeldt jakob disease, thalamus and cerebral cortex
11) Confidence 0.44 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1817656 Disease Relevance 1.22 Pain Relevance 0.25
Interestingly, we observed the same distribution of PrPC in uninfected GT1 cells, indicating that PrPSc infection did not alter PrPC trafficking in GT1 cells (data not shown).
Regulation (alter) of Gene_expression (infection) of PrPSc associated with infection
12) Confidence 0.39 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.10 Pain Relevance 0.10
Interestingly, we observed the same distribution of PrPC in uninfected GT1 cells, indicating that PrPSc infection did not alter PrPC trafficking in GT1 cells (data not shown).
Regulation (alter) of Gene_expression (trafficking) of PrPC associated with infection
13) Confidence 0.39 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.10 Pain Relevance 0.10
Analysis of GA potential direct effect on PrPSc aggregates
Regulation (effect) of Gene_expression (aggregates) of PrPSc
14) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0.37 Pain Relevance 0
As shown in Figure 2c, at 100 µM GA (which represents about 20 times the active concentration of GA in cell culture), the level of PrPSc did not change significantly meaning that this molecule does not exert any direct effect against PrPSc aggregates.
Regulation (effect) of Gene_expression (aggregates) of PrPSc
15) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0 Pain Relevance 0
GA does not act directly on PrPSc aggregates
Neg (not) Regulation (act) of Gene_expression (aggregates) of PrPSc
16) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0 Pain Relevance 0
As shown in Figure 2c, at 100 µM GA (which represents about 20 times the active concentration of GA in cell culture), the level of PrPSc did not change significantly meaning that this molecule does not exert any direct effect against PrPSc aggregates.
Regulation (effect) of Gene_expression (aggregates) of PrPSc
17) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0 Pain Relevance 0
Together, these findings suggest that quinacrine exposure altered the physical properties of PrPSc accumulating in MDR[0>] mice.


Regulation (altered) of Gene_expression (properties) of PrPSc
18) Confidence 0.36 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.28 Pain Relevance 0.07
Further support for targeting of the olfactory system in transmissible prion diseases is found in chronic wasting disease of deer in which the olfactory system is a prominent target for PrPSc deposition [42]; we have also observed PrPSc in the nasal septum of deer and elk with CWD [28].
Regulation (target) of Gene_expression (deposition) of PrPSc in nasal septum associated with creutzfeldt jakob disease and chronic wasting disease
19) Confidence 0.29 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 1.08 Pain Relevance 0.04
However, despite the drastic reduction in the number of LEs, the levels of total PrP and PrPSc were unaltered in Alix-depleted ScGT1 cells.
Regulation (unaltered) of Gene_expression (levels) of PrP
20) Confidence 0.27 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.13 Pain Relevance 0

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