INT135042

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.17
Pain Relevance 1.13

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Anatomy Link Frequency
brain 2
cardiomyocytes 1
skin 1
hearts 1
cervix 1
Tg(MMTV-Notch4)3Rnc (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 8 100.00 Very High Very High Very High
anesthesia 17 96.32 Very High Very High Very High
ketamine 13 95.84 Very High Very High Very High
Enkephalin 2 83.20 Quite High
Dynorphin 2 82.00 Quite High
gABA 16 81.76 Quite High
Hippocampus 9 74.32 Quite High
Thalamus 8 72.64 Quite High
Cholecystokinin 2 71.52 Quite High
medulla 3 70.56 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 40 99.32 Very High Very High Very High
Targeted Disruption 113 99.10 Very High Very High Very High
Neurologic Manifestations 4 98.92 Very High Very High Very High
Impaired Glucose Tolerance 30 96.28 Very High Very High Very High
Cervical Cancer 18 95.72 Very High Very High Very High
Death 40 94.00 High High
Necrosis 2 93.88 High High
Cancer 56 93.52 High High
Neurodegenerative Disease 10 92.16 High High
Creutzfeldt Jakob Disease 31 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using in situ hybridization and immunohistochemistry, we have studied changes in the expression of neuropeptides, acetylcholinesterase and tyrosine hydroxylase in CD1 and FVB wild-type mouse strains, as well as in PrP(C) null mice and in mice overexpressing PrP(C) following intracerebral inoculation with RML or Me7 prions.
Gene_expression (expression) of FVB associated with neuropeptide and sprains and strains
1) Confidence 0.15 Published 2007 Journal Neurobiol. Aging Section Abstract Doc Link 16621165 Disease Relevance 0.28 Pain Relevance 0.43
For acute ethanol challenge, adult male FVB and ADH mice (4–6 month-old) were injected intraperitoneally with ethanol (3 g/kg/d) for 3 consecutive days prior to euthanasia under anesthesia (ketamine/xylazine: 3?
Gene_expression (injected) of FVB associated with anesthesia and ketamine
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.39 Pain Relevance 0.23
, Fas, Fas ligand (FasL), Caspase-8 and pro-caspase-8 was examined in wild-type FVB and ADH hearts following acute ethanol challenge.
Gene_expression (hearts) of FVB in hearts
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.12 Pain Relevance 0.03
At 75 dpi, the concentration of quinacrine in the brains of FVB and MDR0/0 mice were ?
Gene_expression (brains) of FVB in brains
4) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.27 Pain Relevance 0.11
The transient reduction of PrPSc was not observed in FVB[60–90] mice (data not shown), indicating that accumulation of quinacrine to high levels in the brain is required for prion reduction.


Gene_expression (reduction) of FVB in brain
5) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.15 Pain Relevance 0
Mechanical and intracellular Ca2+ properties of murine cardiomyocytes in FVB and ADH mice
Gene_expression (Mechanical) of FVB in cardiomyocytes
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.15 Pain Relevance 0.10
For acute ethanol challenge, adult male FVB and ADH mice (5–7 month-old) were injected intraperitoneally with ethanol (3 g/kg/d) for 3 consecutive days [13] prior to euthanasia under anesthesia (ketamine/xylazine: 3?
Gene_expression (injected) of FVB associated with anesthesia and ketamine
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.29 Pain Relevance 0.20
Effect of acute ethanol challenge on protein phosphatase expression in FVB and ADH mice
Gene_expression (expression) of FVB
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
Mice homozygous for the FVB-TgN (GadGFP) 45704Swn transgene, on a FVB background (FVB-GFP; n?
Gene_expression (transgene) of FVB-TgN
9) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.33 Pain Relevance 0.04
Due to the different properties of the K14E6 transgenic mice in different tissues, we evaluated the expression profile in both the skin and cervix of these mice compared to that of the corresponding tissues from FVB mice.
Gene_expression (expression) of FVB in cervix associated with targeted disruption
10) Confidence 0.04 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 1.09 Pain Relevance 0
Due to the different properties of the K14E6 transgenic mice in different tissues, we evaluated the expression profile in both the skin and cervix of these mice compared to that of the corresponding tissues from FVB mice.
Gene_expression (expression) of FVB in skin associated with targeted disruption
11) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 1.09 Pain Relevance 0

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