INT135077

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 7.03
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTP1) small molecule metabolic process (GSTP1) plasma membrane (GSTP1)
nucleus (GSTP1) intracellular (GSTP1) protein complex (GSTP1)
Anatomy Link Frequency
liver 1
pancreas 1
heart 1
GSTP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 20 99.76 Very High Very High Very High
alcohol 301 99.60 Very High Very High Very High
Inflammation 145 99.40 Very High Very High Very High
Inflammatory marker 12 93.84 High High
dorsal root ganglion 2 80.16 Quite High
cINOD 4 73.12 Quite High
induced neuropathy 1 65.00 Quite High
peripheral neuropathy 2 62.64 Quite High
cytokine 11 51.28 Quite High
palliative 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 181 99.76 Very High Very High Very High
Stress 44 98.96 Very High Very High Very High
Nicotine Addiction 255 98.60 Very High Very High Very High
Apoptosis 15 97.90 Very High Very High Very High
Alcohol Addiction 72 95.64 Very High Very High Very High
Cancer 98 94.36 High High
Drug Induced Neurotoxicity 16 94.04 High High
Disease 111 93.68 High High
Neuropathic Pain 6 90.96 High High
Lung Cancer 5 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The previous study by Ryberg and coworkers support the interaction between GSTM1 and GSTP1 genetic polymorphisms (30).
GSTP1 Binding (interaction) of
1) Confidence 0.48 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.82 Pain Relevance 0.20
This result suggests that there are interactions between GSTM1 and GSTP1 genetic polymorphisms, thus subjects with the combination of GSTM1 null and GSTP1 AG or GG genotypes are more susceptible to smoking-induced inflammation than those with the other genotype combinations.
GSTP1 Binding (interactions) of associated with nicotine addiction and inflammation
2) Confidence 0.48 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.99 Pain Relevance 0.19
Recent clinical reports provided evidence for an association between GSTP1 genotype and cytotoxicity of chemotherapeutic agents (25).
GSTP1 Binding (association) of
3) Confidence 0.37 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2877230 Disease Relevance 0.89 Pain Relevance 0.03
The aims of this study were to investigate whether tobacco smoke exposure increases the level of inflammation biomarkers and the GSTM1 and GSTP1 gene polymorphisms are associated with inflammatory response due to tobacco smoke exposure.
GSTP1 Binding (associated) of associated with inflammatory response, nicotine addiction and inflammation
4) Confidence 0.37 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721922 Disease Relevance 1.10 Pain Relevance 0.22
Therefore, in the present study we tried to investigate whether tobacco smoke exposure increases the level of inflammation biomarkers and the GSTM1 and GSTP1 gene polymorphisms are associated with inflammatory response due to tobacco smoke exposure.


GSTP1 Binding (associated) of associated with inflammatory response, nicotine addiction and inflammation
5) Confidence 0.37 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 1.18 Pain Relevance 0.37
Table 3 also shows the association of NAT2, GSTM1, GSTT1, and GSTP1 genotypes with chemical-related sensitivity scores (?
GSTP1 Binding (association) of
6) Confidence 0.36 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.22 Pain Relevance 0
Chemoresistance and poor survival were significantly associated with TS 5'-UTR 3G-genotype (2R/3G, 3C/3G, 3G/3G) and GSTP1 105 A/A homozygous genotype.
GSTP1 Binding (associated) of
7) Confidence 0.36 Published 2006 Journal J. Clin. Oncol. Section Body Doc Link 16622263 Disease Relevance 0.08 Pain Relevance 0
We assessed dominant, recessive, and additive models to examine GSTP1 gene–environment interactions, and an additive model proved to be the best choice.
GSTP1 Binding (interactions) of
8) Confidence 0.33 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.59 Pain Relevance 0
Alteration of intracellular apoptosis pathways might represent an alternative or additional explanation to varying detoxification efficacies: GSTP1 monomers bind- and thus inactivate the stress-inducible Jun N-terminal kinase (JNK) [38].
GSTP1 Spec (might) Binding (bind) of associated with stress and apoptosis
9) Confidence 0.31 Published 2007 Journal J Transl Med Section Body Doc Link PMC2245909 Disease Relevance 0.88 Pain Relevance 0.11
Evidence has indicated that small amounts of alcohol may be removed via interaction with fatty acids to form fatty acid ethyl esters (FAEEs), the latter has been shown to contribute to damage to the heart, liver and pancreas [88,89].


FAEEs Binding (interaction) of in pancreas associated with alcohol
10) Confidence 0.08 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 0.10 Pain Relevance 0.23
Evidence has indicated that small amounts of alcohol may be removed via interaction with fatty acids to form fatty acid ethyl esters (FAEEs), the latter has been shown to contribute to damage to the heart, liver and pancreas [88,89].


FAEEs Binding (interaction) of in liver associated with alcohol
11) Confidence 0.03 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 0.10 Pain Relevance 0.23
Evidence has indicated that small amounts of alcohol may be removed via interaction with fatty acids to form fatty acid ethyl esters (FAEEs), the latter has been shown to contribute to damage to the heart, liver and pancreas [88,89].


FAEEs Binding (interaction) of in heart associated with alcohol
12) Confidence 0.03 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 0.10 Pain Relevance 0.23

General Comments

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