INT135087

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.39
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) RNA binding (Phax) nucleus (Phax)
cytoplasm (Phax)
Anatomy Link Frequency
sciatic nerve 2
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 75 100.00 Very High Very High Very High
analgesia 15 100.00 Very High Very High Very High
Sciatic nerve 10 100.00 Very High Very High Very High
intrathecal 56 99.98 Very High Very High Very High
qutenza 151 99.82 Very High Very High Very High
Inflammation 35 98.72 Very High Very High Very High
Hyperalgesia 6 97.76 Very High Very High Very High
allodynia 15 94.16 High High
Dorsal horn neuron 4 93.68 High High
depression 14 93.48 High High
Disease Link Frequency Relevance Heat
Nociception 40 100.00 Very High Very High Very High
Spinal Cord Injury 9 99.84 Very High Very High Very High
Nervous System Injury 96 99.16 Very High Very High Very High
INFLAMMATION 35 98.72 Very High Very High Very High
Hyperalgesia 10 97.76 Very High Very High Very High
Neuropathic Pain 39 94.16 High High
Depression 10 93.48 High High
Pain 40 91.12 High High
Hypersensitivity 24 89.48 High High
Injury 15 78.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of phosphorylated-p38 were decreased in SCI animals receiving minocycline.
Negative_regulation (decreased) of Gene_expression (Levels) of phosphorylated-p38 associated with spinal cord injury
1) Confidence 0.17 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16624951 Disease Relevance 1.56 Pain Relevance 0.88
Intrathecal administration of RTX prevented the reduction in PWL caused by inflammation (control, 9.5±0.9 s (n?
Negative_regulation (prevented) of Gene_expression (administration) of RTX associated with inflammation and intrathecal
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.81 Pain Relevance 0.65
Intrathecal administration of RTX-induced analgesia
Negative_regulation (administration) of Gene_expression (analgesia) of RTX-induced associated with analgesia and intrathecal
3) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.48 Pain Relevance 0.86
Third, SNI-induced microglial proliferation and p38 activation in the spinal cord was reduced by a complete sciatic nerve blockade with bupivacaine microspheres but not by a selective blockade of nociceptive fibers with RTX.
Neg (not) Negative_regulation (reduced) of Gene_expression (activation) of RTX in sciatic nerve associated with nociception, nervous system injury, sciatic nerve and spinal cord
4) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.54 Pain Relevance 0.76
Capsaicin but not RTX non-specific depresses BR discharge at high concentrations
Negative_regulation (depresses) of Gene_expression (non) of RTX associated with qutenza
5) Confidence 0.03 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.96

General Comments

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