INT135088

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 8.93
Pain Relevance 8.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) RNA binding (Phax) nucleus (Phax)
cytoplasm (Phax)
Anatomy Link Frequency
spinal 1
sciatic nerve 1
nerve 1
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 30 100.00 Very High Very High Very High
nerve block 14 100.00 Very High Very High Very High
tetrodotoxin 2 100.00 Very High Very High Very High
Sciatic nerve 43 99.72 Very High Very High Very High
Inflammation 352 99.52 Very High Very High Very High
interstitial cystitis 3 99.16 Very High Very High Very High
qutenza 84 99.12 Very High Very High Very High
c fibre 116 98.52 Very High Very High Very High
agonist 48 98.00 Very High Very High Very High
intrathecal 56 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

132 100.00 Very High Very High Very High
Neurogenic Inflammation 6 99.96 Very High Very High Very High
Spinal Cord Injury 9 99.84 Very High Very High Very High
INFLAMMATION 359 99.36 Very High Very High Very High
Interstitial Cystitis 3 99.16 Very High Very High Very High
Nervous System Injury 193 98.66 Very High Very High Very High
Hypersensitivity 75 98.00 Very High Very High Very High
Nociception 173 95.76 Very High Very High Very High
Pain 125 95.32 Very High Very High Very High
Injury 50 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RTX activity could be blocked by capsazepine or SB-366791, a TRPV1 antagonist, but not tetrodotoxin, a Na(+)-channel blocker, and could be inhibited by pretreatment with capsaicin but not the TRPA1 agonist, allyl isothiocyanate.
Negative_regulation (blocked) of RTX associated with tetrodotoxin, qutenza, antagonist and agonist
1) Confidence 0.36 Published 2009 Journal Neuroscience Section Abstract Doc Link 19778582 Disease Relevance 0 Pain Relevance 1.03
In conclusion, the effectiveness of resiniferatoxin in the treatment of interstitial cystitis remains unknown.
Negative_regulation (effectiveness) of resiniferatoxin associated with interstitial cystitis
2) Confidence 0.33 Published 2008 Journal Int Urogynecol J Pelvic Floor Dysfunct Section Abstract Doc Link 18563284 Disease Relevance 0.40 Pain Relevance 0.40
RTX activity could be blocked by capsazepine or SB-366791, a TRPV1 antagonist, but not tetrodotoxin, a Na(+)-channel blocker, and could be inhibited by pretreatment with capsaicin but not the TRPA1 agonist, allyl isothiocyanate.
Negative_regulation (inhibited) of RTX associated with tetrodotoxin, qutenza, antagonist and agonist
3) Confidence 0.26 Published 2009 Journal Neuroscience Section Abstract Doc Link 19778582 Disease Relevance 0 Pain Relevance 1.06
Levels of phosphorylated-p38 were decreased in SCI animals receiving minocycline.
Negative_regulation (decreased) of phosphorylated-p38 associated with spinal cord injury
4) Confidence 0.23 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16624951 Disease Relevance 1.56 Pain Relevance 0.87
Vehicle was also used to dilute RTX (100 ng/?
Negative_regulation (dilute) of RTX
5) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.06 Pain Relevance 0.12
We observe that peripherally administered RTX temporarily eliminates behavioral responses to both A?
Negative_regulation (administered) of RTX
6) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.16 Pain Relevance 0.51
RTX blocks neurogenic inflammation (Fig. 7)
Negative_regulation (blocks) of RTX associated with inflammation and neurogenic inflammation
7) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242785 Disease Relevance 0.25 Pain Relevance 0.43
Furthermore, RTX-induced loss of TRPV1 staining was localized to the lumbar spinal segments closest to the level of the intrathecal injection (T12-L3).
Negative_regulation (loss) of RTX-induced in spinal associated with intrathecal
8) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.67 Pain Relevance 0.46
Spared nerve injury: This surgery was performed at least 3 hours after bupivacaine or RTX block and after sensory/motor and radiant heat testing.
Negative_regulation (block) of RTX in nerve associated with nervous system injury
9) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 0.28 Pain Relevance 0.12
Nerve block with resiniferatoxin (RTX): The sciatic nerve was exposed as previously described, and RTX solution (0.01%, 100 ?
Negative_regulation (block) of RTX in sciatic nerve associated with nerve block and sciatic nerve
10) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 0.28 Pain Relevance 0.21
We observed a decrease in balloon pressure threshold for both non-RTX (n = 10; p < 0.001) and RTX TNBS animals (n = 10; p < 0.001) (Fig 4b).
Negative_regulation (decrease) of RTX TNBS
11) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 0.77 Pain Relevance 0.40
These changes are associated with a decrease in balloon pressure in response to colorectal distension in non-RTX and RTX lesioned animals.
Negative_regulation (decrease) of non-RTX
12) Confidence 0.03 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2758842 Disease Relevance 0.64 Pain Relevance 0.45
Behavioral studies determined that both inflamed non-RTX and RTX animals showed a decrease in balloon pressure threshold as compared to controls.
Negative_regulation (decrease) of RTX
13) Confidence 0.03 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2758842 Disease Relevance 1.09 Pain Relevance 0.69
We observed a decrease in balloon pressure threshold for both non-RTX (n = 10; p < 0.001) and RTX TNBS animals (n = 10; p < 0.001) (Fig 4b).
Negative_regulation (decrease) of non-RTX
14) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 0.76 Pain Relevance 0.40
Behavioral studies determined that both inflamed non-RTX and RTX animals showed a decrease in balloon pressure threshold as compared to controls.
Negative_regulation (decrease) of non-RTX
15) Confidence 0.01 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2758842 Disease Relevance 1.09 Pain Relevance 0.69
These changes are associated with a decrease in balloon pressure in response to colorectal distension in non-RTX and RTX lesioned animals.
Negative_regulation (decrease) of RTX
16) Confidence 0.01 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2758842 Disease Relevance 0.64 Pain Relevance 0.45

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