INT1351

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Context Info
Confidence 0.57
First Reported 1977
Last Reported 2010
Negated 2
Speculated 4
Reported most in Abstract
Documents 131
Total Number 140
Disease Relevance 89.48
Pain Relevance 98.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
neurons 27
PAG 5
spinal cord 4
midbrain 4
spinal 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 1159 100.00 Very High Very High Very High
Periaqueductal grey 508 100.00 Very High Very High Very High
gABA 491 100.00 Very High Very High Very High
agonist 361 100.00 Very High Very High Very High
Locus ceruleus 339 100.00 Very High Very High Very High
antagonist 335 100.00 Very High Very High Very High
Antinociceptive 238 100.00 Very High Very High Very High
Rostral ventromedial medulla 204 100.00 Very High Very High Very High
Analgesic 200 100.00 Very High Very High Very High
Endocannabinoid 189 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2373 100.00 Very High Very High Very High
Nociception 393 100.00 Very High Very High Very High
Depression 11 100.00 Very High Very High Very High
Sleep Disorders 1111 99.96 Very High Very High Very High
Sprains And Strains 416 99.80 Very High Very High Very High
Injury 87 99.72 Very High Very High Very High
Pain 594 99.68 Very High Very High Very High
Anxiety Disorder 513 99.68 Very High Very High Very High
Targeted Disruption 428 99.52 Very High Very High Very High
Stress 87 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analgesia-producing PAG stimulation altered the spontaneous activity of 80% of the neurons in the MRF (both excitation and inhibition were observed) and inhibited the noxious-evoked excitation of 75% of MRF neurons.
Gene_expression (producing) of PAG in neurons associated with urological neuroanatomy and analgesia
1) Confidence 0.57 Published 1980 Journal Brain Res. Section Abstract Doc Link 6251951 Disease Relevance 0.52 Pain Relevance 0.68
Moreover, bilateral lesions of the rostral lateral PAG produced even more dramatic effects in inhibiting insect hunting and restoring maternal behavior.
Gene_expression (produced) of PAG in lateral associated with central grey
2) Confidence 0.57 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16510737 Disease Relevance 0.66 Pain Relevance 1.04
PAG/RVM activation was observed during the final 6 s of offset trials but not during either of the control trials and this difference across trials was significant.
Gene_expression (activation) of PAG in RVM associated with periaqueductal grey and rostral ventromedial medulla
3) Confidence 0.55 Published 2009 Journal Neuroimage Section Abstract Doc Link 19375510 Disease Relevance 0.60 Pain Relevance 1.02
In general, the more efficacious analgesia-producing PAG loci were localized in the ventral-ventrolateral PAG.
Gene_expression (producing) of PAG in ventral associated with urological neuroanatomy and analgesia
4) Confidence 0.51 Published 1977 Journal Brain Res. Section Abstract Doc Link 191150 Disease Relevance 0.89 Pain Relevance 1.31
Double fluorescence immunohistochemistry for c-Fos and serotonin revealed that PAG/NRD/EW neurons expressing c-Fos were non-serotonergic.
Gene_expression (expressing) of PAG in EW neurons associated with central grey and serotonin
5) Confidence 0.48 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10984628 Disease Relevance 0.52 Pain Relevance 0.70
Destruction of the caudal PAG consistently produced large increases in thresholds for analgesia at rostral stimulation sites; however, destruction of the rostral areas did not affect thresholds at caudal PAG sites.
Gene_expression (produced) of PAG associated with central grey and analgesia
6) Confidence 0.47 Published 1979 Journal Pain Section Abstract Doc Link 503554 Disease Relevance 0.51 Pain Relevance 0.85
M), local electrical stimulation evoked IPSCs in PAG neurons which were abolished by tetrodotoxin (300 nM, n = 3) and by the GABAA antagonist SR95531 (10 ?
Gene_expression (neurons) of PAG in neurons associated with tetrodotoxin, antagonist and periaqueductal grey
7) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.24 Pain Relevance 0.41
We first examined which of the 5-HT1 receptors are present within the PAG by real time PCR.
Gene_expression (present) of PAG associated with periaqueductal grey
8) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.28 Pain Relevance 0.59
An initial histological experiment verified the existence of dopamine neurons within the vPAG using dopamine transporter and tyrosine hydroxylase antibodies visualized with confocal microscopy.
Gene_expression (using) of vPAG in dopamine neurons
9) Confidence 0.41 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 19225762 Disease Relevance 0.09 Pain Relevance 0
In this regard, it has previously been shown that 5-HT1A receptor activation produces postsynaptic inhibition within the PAG [45].
Gene_expression (produces) of PAG associated with periaqueductal grey
10) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.38 Pain Relevance 1.00
Furthermore, analgesic drugs such as opioids produce analgesia from within the PAG via a descending pathway which projects via the rostral ventromedial medulla to the spinal cord and medullary dorsal horn [19].
Gene_expression (produce) of PAG in dorsal horn associated with periaqueductal grey, analgesic, dorsal horn, opioid, spinal cord, rostral ventromedial medulla and analgesia
11) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.84 Pain Relevance 1.40
However, no significant alteration was detected in the NR2A expression in the PAG after injury (Fig. 1).
Gene_expression (expression) of PAG associated with injury and central grey
12) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.66 Pain Relevance 0.93
Injections of wheat germ agglutinin-horseradish peroxidase were made into the PAG of 12 adult rats and into the deep layer of the superior colliculus in 2 rats.
Gene_expression (made) of PAG in superior colliculus associated with central grey
13) Confidence 0.38 Published 1989 Journal Brain Res. Bull. Section Abstract Doc Link 2478264 Disease Relevance 0.49 Pain Relevance 0.35
This suggests that some of the modulatory influences involve endogenous opiate-related mechanisms. (4) Many of the oralis neurons were identified as trigeminothalamic relay neurons on the basis of their antidromic response to ventrobasal thalamic stimulation; PAG and NRM conditioning produced not only a suppression of their orthodromic responses to oral-facial stimuli but also caused a decrease in the antidromic excitability of the relay neurons.
Gene_expression (produced) of PAG in neurons associated with raphe magnus, opiate and central grey
14) Confidence 0.38 Published 1981 Journal Pain Section Abstract Doc Link 6262699 Disease Relevance 0.24 Pain Relevance 0.63
We monitored the activity of vlPAG neurons in HCRT-ko mice and found that 64% of neurons sampled (28 of 44) were active during both wake and REM sleep, 27% (12 of 44) were wake-active, and 9% (4 of 44) were active during REM sleep [25].
Gene_expression (neurons) of vlPAG in neurons
15) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.78 Pain Relevance 0.03
expression in the PAG has not been characterized.
Gene_expression (expression) of PAG associated with urological neuroanatomy
16) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2650089 Disease Relevance 0.96 Pain Relevance 1.52
The results showed a topographical distribution of neuropeptides over the rostrocaudal extent of the PAG that is compatible with the emerging theory that the anatomical and functional specificity of the PAG is expressed in the form of longitudinally arranged neuronal columns that extend for varying distances along the rostrocaudal axis of the midbrain PAG.
Gene_expression (expressed) of PAG in midbrain associated with neuropeptide, urological neuroanatomy and midbrain
17) Confidence 0.35 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7860799 Disease Relevance 0.75 Pain Relevance 0.67
PAG/NRD stimulation-produced inhibition of the VIR was completely eliminated by bilateral section of the dorsolateral funiculi.
Gene_expression (produced) of PAG associated with central grey
18) Confidence 0.35 Published 1986 Journal Brain Res. Section Abstract Doc Link 3697757 Disease Relevance 0.93 Pain Relevance 0.62
These PAG neurons were chiefly distributed in the ventrolateral PAG subdivision and the ventral parts of medial PAG subdivision at the middle and caudal levels of PAG.
Gene_expression (levels) of PAG in medial associated with central grey
19) Confidence 0.34 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 1705670 Disease Relevance 0.64 Pain Relevance 0.80
The results demonstrate a significant increase in NR2B expression in the lateral areas of the PAG (LPAG).
Gene_expression (expression) of PAG in lateral areas associated with central grey
20) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.06 Pain Relevance 1.30

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