INT135102

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca)
nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)
Anatomy Link Frequency
pigment granules 2
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
sSRI 91 99.70 Very High Very High Very High
agonist 5 97.16 Very High Very High Very High
antidepressant 39 96.64 Very High Very High Very High
Inflammation 5 89.04 High High
antagonist 10 81.56 Quite High
depression 34 66.52 Quite High
qutenza 3 51.80 Quite High
Kinase C 33 48.32 Quite Low
gABA 1 38.16 Quite Low
Calcium channel 8 31.96 Quite Low
Disease Link Frequency Relevance Heat
Cough 13 99.92 Very High Very High Very High
Congenital Anomalies 6 89.28 High High
Depression 40 66.52 Quite High
INFLAMMATION 4 61.52 Quite High
Suicidal Behaviour 5 54.52 Quite High
Affective Disorder 12 46.32 Quite Low
Stress 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, SSRI treatment can result in a translocation of PKA into various intracellular compartments, potentially corresponding to its eventual antidepressant effect (Mori et al 1998).
Positive_regulation (result) of Localization (translocation) of PKA associated with antidepressant and ssri
1) Confidence 0.17 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.27 Pain Relevance 0.38
When FSK is applied to cells, cAMP levels increase [12], leading to PKA activation [22] and eventual aggregation of pigment granules.
Positive_regulation (leading) of Localization (aggregation) of PKA in pigment granules
2) Confidence 0.03 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2225403 Disease Relevance 0 Pain Relevance 0.03
In conclusion, PAR2 stimulation exaggerates TRPV1-dependent cough by activation of diverse mechanism(s), including PKC, PKA, and prostanoid release.
Positive_regulation (activation) of Localization (release) of PKA associated with cough
3) Confidence 0.03 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16627674 Disease Relevance 0.94 Pain Relevance 0.34

General Comments

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