INT135120

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.01
Pain Relevance 8.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atf6b) nucleus (Atf6b) intracellular (Atf6b)
DNA binding (Atf6b)
Anatomy Link Frequency
neuronal 3
NAcc 1
intermediary 1
Atf6b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 43 100.00 Very High Very High Very High
addiction 9 100.00 Very High Very High Very High
Spinal cord 6 99.84 Very High Very High Very High
withdrawal 12 99.50 Very High Very High Very High
Nucleus accumbens 63 99.24 Very High Very High Very High
Morphine 41 99.02 Very High Very High Very High
Kinase C 24 98.36 Very High Very High Very High
antidepressant 103 98.04 Very High Very High Very High
Calcitonin gene-related peptide 10 95.82 Very High Very High Very High
spinal dorsal horn 1 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 8 100.00 Very High Very High Very High
Disease 98 99.56 Very High Very High Very High
Alzheimer's Dementia 38 98.46 Very High Very High Very High
Targeted Disruption 30 98.04 Very High Very High Very High
Anxiety Disorder 44 91.04 High High
Death 5 90.84 High High
Depression 86 90.72 High High
Ganglion Cysts 4 90.64 High High
Congenital Anomalies 7 86.12 High High
Headache 2 71.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
cAMP response-element binding protein (CREB), a transcription factor involved in learning, memory and drug addiction, is phosphorylated by calcium-calmodulin-dependent protein kinase IV (CaMKIV).
Phosphorylation (phosphorylated) of cAMP response-element binding protein associated with drug dependence and addiction
1) Confidence 0.61 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16630062 Disease Relevance 0.50 Pain Relevance 0.85
Chronic morphine exposure and withdrawal significantly increased phosphorylation of N-methyl-D-aspartate receptor subunit NR2B as well as the activated forms of extracellular signal-regulated kinase and the cAMP response element binding protein in SC.
Phosphorylation (phosphorylation) of cAMP response element binding protein associated with nmda receptor, withdrawal, spinal cord and morphine
2) Confidence 0.58 Published 2009 Journal FASEB J. Section Abstract Doc Link 18772347 Disease Relevance 0.23 Pain Relevance 1.34
Furthermore, the results indicate that acute and long-term antidepressant treatments induce TrkB-mediated activation of phospholipase-Cgamma1 (PLCgamma1) and increase the phosphorylation of cAMP-related element binding protein, a major transcription factor mediating neuronal plasticity.
Phosphorylation (phosphorylation) of cAMP-related element binding protein in neuronal associated with antidepressant
3) Confidence 0.58 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.70
CGRP activated Ca(2+)-calmodulin-dependent kinase II, which became localized to the perimembrane region and neuronal processes, a phenomenon already apparent after 30 min and accompanied by a parallel increase in cAMP-response element-binding protein (CREB) phosphorylation and nuclear translocation.
Phosphorylation (phosphorylation) of cAMP-response element-binding protein in neuronal associated with calcitonin gene-related peptide
4) Confidence 0.57 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.43 Pain Relevance 0.61
Additionally, NAN-190 decreased and 8-OH-DPAT increased phosphorylated cAMP response element-binding protein (CREB) levels in WT mice but not in KO mice.
Phosphorylation (phosphorylated) of cAMP response element-binding protein
5) Confidence 0.54 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20164327 Disease Relevance 0.60 Pain Relevance 0.35
Moreover, the expressions of c-Fos, phosphorylated calcium/calmodulin-dependent protein kinase-IIalpha (pCaMK-IIalpha), and phosphorylated cAMP response element-binding protein (pCREB) were increased by a single i.c.v. morphine injection at various time points, but the expressions of phosphorylated extracellular signal-regulated protein kinase1/2 (pERK1/2) and phosphorylated IkappaB (pIkappaB) were not.
Phosphorylation (phosphorylated) of cAMP response element-binding protein associated with morphine
6) Confidence 0.51 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.71
CaMKIV activates several transcription factors such as ATF-1, MEF2D and NF-kappaB [4-6], and is a key regulator of neuronal gene expression that stimulates transcription through the phosphorylation of the cAMP response element binding protein (CREB) and activation of the CREB co-activator, CREB binding protein (CBP) [2,3,7].
Phosphorylation (phosphorylation) of cAMP response element binding protein in neuronal
7) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.19 Pain Relevance 0.22
Moreover, the expressions of c-Fos, phosphorylated calcium/calmodulin-dependent protein kinase-IIalpha (pCaMK-IIalpha), and phosphorylated cAMP response element-binding protein (pCREB) were increased by a single i.c.v. morphine injection at various time points, but the expressions of phosphorylated extracellular signal-regulated protein kinase1/2 (pERK1/2) and phosphorylated IkappaB (pIkappaB) were not.
Phosphorylation (phosphorylated) of cAMP response element-binding protein associated with morphine
8) Confidence 0.39 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.70
In addition, GTS inhibited the increase of cAMP response element binding protein (CREB) phosphorylation.
Phosphorylation (phosphorylation) of cAMP response element binding protein
9) Confidence 0.32 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 18365685 Disease Relevance 0.07 Pain Relevance 0.64
In the NAcc, activated ERK controls the state of phosphorylation of transcription factors including Elk1 and cAMP response element binding protein (CREB) and, thereby, initiates a gene transcription program that is supposed to lead to the long-term effects of repeated exposure to psychostimulants [22].
Phosphorylation (phosphorylation) of cAMP response element binding protein in NAcc associated with nucleus accumbens
10) Confidence 0.28 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.51
Amyloid peptide deposition, a major pathological feature of AD, interferes with the phosphorylation of cAMP-response element-binding protein (CREB) [135].
Phosphorylation (phosphorylation) of cAMP-response element-binding protein associated with alzheimer's dementia and disease
11) Confidence 0.26 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2845130 Disease Relevance 1.20 Pain Relevance 0.78
Subsequently, phosphorylation of downstream targets, including ERK kinase (MEK), mitogen-activated protein kinase (MAPK) and cAMP response element binding protein (CREB) were also significantly attenuated in Ng knockout mice following NMDA treatment 11.
Phosphorylation (phosphorylation) of cAMP response element binding protein associated with targeted disruption
12) Confidence 0.23 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.69 Pain Relevance 0.39
In slice preparations, it has been shown that NO–cGMP–PKG resulted in the phosphorylation of the transcription factor CREB (cAMP response element binding protein) in the cell bodies of postsynaptic neurones by a mechanism involving Ca2+ release from ryanodine-sensitive stores (Lu et al., 1999; Lu & Hawkins, 2002), implicating cyclic ADP ribose as an intermediary.
Phosphorylation (phosphorylation) of cAMP response element binding protein in intermediary
13) Confidence 0.16 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.09 Pain Relevance 0.23

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