INT135127

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.57
Pain Relevance 0

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nucleoplasm (RXRB, NR1I2) nucleus (RXRB, NR1I2) signal transduction (NR1I2)
RXRB (Homo sapiens)
NR1I2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 4 28.64 Quite Low
Paracetamol 12 25.00 Low Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 8 75.00 Quite High
Rheumatoid Arthritis 24 40.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Steroid and xenobiotic receptor (SXR) or human pregnane X receptor (hPXR) dimerizes with retinoid X receptor (RXR) and regulates the transcription of genes encoding xenobiotic-metabolizing enzymes such as CYP3A4.
retinoid X receptor Binding (dimerizes) of xenobiotic receptor
1) Confidence 0.29 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16632523 Disease Relevance 0.14 Pain Relevance 0
Steroid and xenobiotic receptor (SXR) or human pregnane X receptor (hPXR) dimerizes with retinoid X receptor (RXR) and regulates the transcription of genes encoding xenobiotic-metabolizing enzymes such as CYP3A4.
retinoid X receptor Binding (dimerizes) of SXR
2) Confidence 0.29 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16632523 Disease Relevance 0.14 Pain Relevance 0
Steroid and xenobiotic receptor (SXR) or human pregnane X receptor (hPXR) dimerizes with retinoid X receptor (RXR) and regulates the transcription of genes encoding xenobiotic-metabolizing enzymes such as CYP3A4.
retinoid X receptor Binding (dimerizes) of hPXR
3) Confidence 0.29 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16632523 Disease Relevance 0.14 Pain Relevance 0
Steroid and xenobiotic receptor (SXR) or human pregnane X receptor (hPXR) dimerizes with retinoid X receptor (RXR) and regulates the transcription of genes encoding xenobiotic-metabolizing enzymes such as CYP3A4.
retinoid X receptor Binding (dimerizes) of pregnane X receptor
4) Confidence 0.25 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16632523 Disease Relevance 0.14 Pain Relevance 0

General Comments

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