INT135131

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.32
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP3A4) oxidoreductase activity (CYP3A4) endoplasmic reticulum (CYP3A4)
enzyme binding (CYP3A4) lipid metabolic process (CYP3A4) cytoplasm (CYP3A4)
Anatomy Link Frequency
gut 6
liver 2
CYP3A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 6 96.36 Very High Very High Very High
Bile 45 84.12 Quite High
Potency 22 72.76 Quite High
lidocaine 2 38.20 Quite Low
Inflammation 17 5.00 Very Low Very Low Very Low
tolerance 16 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Versed 7 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 80 99.04 Very High Very High Very High
Rheumatoid Arthritis 12 95.64 Very High Very High Very High
Gallstones 38 92.08 High High
Hepatocellular Cancer 4 88.80 High High
Hypoalbuminemia 6 88.52 High High
Breast Cancer 8 82.20 Quite High
Injury 10 80.20 Quite High
Toxicity 18 78.12 Quite High
Syndrome 8 72.80 Quite High
Hyperbilirubinemia 86 69.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, retinoids activate the RXR/SXR-mediated pathway and regulate the expression of CYP3A4.
Regulation (regulate) of Gene_expression (expression) of CYP3A4
1) Confidence 0.59 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16632523 Disease Relevance 0.60 Pain Relevance 0.31
It is unclear whether various natural and synthetic retinoids can regulate the expression of CYP3A4.
Regulation (regulate) of Gene_expression (expression) of CYP3A4
2) Confidence 0.59 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16632523 Disease Relevance 0.35 Pain Relevance 0.03
The impaired expression of hepatic proteins including CYP3A4 might affect the metabolism of endogenous cortisol into its metabolite; 6 ?
Spec (might) Regulation (affect) of Gene_expression (expression) of CYP3A4
3) Confidence 0.41 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716776 Disease Relevance 0.96 Pain Relevance 0.03
It is suggested that CYP3A4 can metabolize lithocholic acid into 3-dehydrolithocholic acid, a potent activator of the nuclear receptors, pregnane X receptor and 1,25-dihydroxy vitamin D3 receptor, which are known to regulate the expression of CYP3A4 (Bodin et al. 2005).
Regulation (regulate) of Gene_expression (expression) of CYP3A4
4) Confidence 0.41 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716776 Disease Relevance 1.14 Pain Relevance 0.08
The 2677G > T polymorphism has recently been suggested as the possible candidate.38 Persons homozygous for the MDR1 2677T allele, which is frequently linked to the 3435T allele, show enhanced constitutive CYP3A4 expression in the liver and gut when compared to subjects homozygous for the 2677G allele.39
Regulation (gut) of Gene_expression (expression) of CYP3A4 in gut
5) Confidence 0.16 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.27 Pain Relevance 0
The 2677G > T polymorphism has recently been suggested as the possible candidate.38 Persons homozygous for the MDR1 2677T allele, which is frequently linked to the 3435T allele, show enhanced constitutive CYP3A4 expression in the liver and gut when compared to subjects homozygous for the 2677G allele.39
Regulation (constitutive) of Gene_expression (expression) of CYP3A4 in gut
6) Confidence 0.16 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.26 Pain Relevance 0
However, the reported allelic frequencies and the functional data demonstrate only a limited role of these variants in CYP3A4 expression and activity [Eiselt et al., 2001; Wandel et al., 2000].
Regulation (role) of Gene_expression (expression) of CYP3A4
7) Confidence 0.09 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.22 Pain Relevance 0
The 2677G > T polymorphism has recently been suggested as the possible candidate.38 Persons homozygous for the MDR1 2677T allele, which is frequently linked to the 3435T allele, show enhanced constitutive CYP3A4 expression in the liver and gut when compared to subjects homozygous for the 2677G allele.39
Regulation (constitutive) of in liver Gene_expression (expression) of CYP3A4 in gut
8) Confidence 0.05 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.26 Pain Relevance 0
The 2677G > T polymorphism has recently been suggested as the possible candidate.38 Persons homozygous for the MDR1 2677T allele, which is frequently linked to the 3435T allele, show enhanced constitutive CYP3A4 expression in the liver and gut when compared to subjects homozygous for the 2677G allele.39
Regulation (gut) of in liver Gene_expression (expression) of CYP3A4 in gut
9) Confidence 0.05 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697529 Disease Relevance 0.27 Pain Relevance 0

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