INT135132

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 8.63
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1H4) signal transduction (NR1H4) nucleus (NR1H4)
Anatomy Link Frequency
liver 2
bile 1
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 11 97.58 Very High Very High Very High
cINOD 7 97.00 Very High Very High Very High
nud 1 93.00 High High
Inflammation 41 90.00 High High
agonist 115 84.92 Quite High
Potency 3 81.28 Quite High
long-term potentiation 2 74.16 Quite High
depression 4 72.72 Quite High
dopamine receptor 4 69.92 Quite High
GABA receptor 4 68.40 Quite High
Disease Link Frequency Relevance Heat
Carcinoma 75 99.66 Very High Very High Very High
Cancer 341 99.36 Very High Very High Very High
Diabetes Mellitus 132 99.16 Very High Very High Very High
Rheumatoid Arthritis 156 98.76 Very High Very High Very High
Colon Cancer 146 98.20 Very High Very High Very High
Hepatocellular Cancer 10 96.88 Very High Very High Very High
INFLAMMATION 55 96.76 Very High Very High Very High
Adenoma 1 96.56 Very High Very High Very High
Schizophrenia 200 94.92 High High
Vomiting 2 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we found 3 retinoic X receptor (RXR) related signaling pathways: LXR (liver X receptor)/RXR activation, FXR (farnesoid X receptor)/RXR activation, and PPAR (peroxisome proliferators-activated receptor) signaling.
Positive_regulation (activation) of RXR in liver
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894047 Disease Relevance 0.84 Pain Relevance 0.24
Moreover, we found 3 retinoic X receptor (RXR) related signaling pathways: LXR (liver X receptor)/RXR activation, FXR (farnesoid X receptor)/RXR activation, and PPAR (peroxisome proliferators-activated receptor) signaling.
Positive_regulation (activation) of FXR in liver
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894047 Disease Relevance 0.90 Pain Relevance 0.24
However, treatment with LG268 led to modest increases in both a low- and high-molecular weight forms of SUMO1-RXR (lane 3R).
Positive_regulation (increases) of SUMO1-RXR
3) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.06 Pain Relevance 0.03
The competitive binding model implicates competition for binding to the degenerate DR-1 site between RXR:PPAR?
Positive_regulation (degenerate) of RXR
4) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0.04
Along with the effect seen in lane 3P of Figure 9b, the SUMOylation of RXR induced by rosiglitazone (lane 4R) lends additional support to the hypothesis that the binding of ligand by one nuclear receptor may cause cross-SUMOylation of the unliganded dimer partner.
Positive_regulation (induced) of RXR
5) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0.03
Therefore, the activation of the RXR/PPAR?
Positive_regulation (activation) of RXR
6) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.81 Pain Relevance 0.25
accumulation of the phosphorylated (i.e., inactivated) form of RXR?
Positive_regulation (accumulation) of RXR
7) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.00 Pain Relevance 0
The above findings indicate that the activation of the RXR/PPAR?
Positive_regulation (activation) of RXR
8) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.88 Pain Relevance 0.07
processes are critical for the transcriptional activity of RAR/RXR
Positive_regulation (critical) of RXR
9) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.13 Pain Relevance 0
of human cancers, including HCC, which show the accumulation of p-RXR?
Positive_regulation (accumulation) of RXR associated with cancer and carcinoma
10) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.11 Pain Relevance 0.04
The results revealed that eight out of 13 retinoids screened significantly induced the RXR/SXR-mediated pathway in Huh7 cells.
Positive_regulation (induced) of RXR
11) Confidence 0.10 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16632523 Disease Relevance 0.55 Pain Relevance 0.10
Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells.
Positive_regulation (activate) of RXR associated with hepatocellular cancer
12) Confidence 0.10 Published 2006 Journal Toxicol. Sci. Section Title Doc Link 16632523 Disease Relevance 0.36 Pain Relevance 0.03
The exact mechanism by which a bile acid sequestrant may improve glycemic control in patients with type 2 diabetes is not fully understood, but may involve activation of the nuclear receptors farnesoid X receptor (FXR) in the liver and intestine and TGR5 in the intestine [72,81].
Positive_regulation (activation) of farnesoid X receptor in bile associated with bile and diabetes mellitus
13) Confidence 0.04 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3022752 Disease Relevance 0.45 Pain Relevance 0.18
Recombinant DREAM, glutathione S-transferase (GST)-fused VDR and RXR (50–100 ng) and in vitro translated RXR, VDR and RAR were used in the assays with labeled DRE, DR3 and DR5 oligonucleotides as described previously (30).
Positive_regulation (fused) of RXR
14) Confidence 0.04 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.08 Pain Relevance 0
Therefore, a combination of reduced binding affinity and abnormal association with coactivators could explain the lack of transcriptional activity of the RXR/VDR heterodimer upon binding to the DRE.
Positive_regulation (activity) of RXR
15) Confidence 0.03 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
The transcriptional activity of PPAR depends on the presence of the retinoic X receptor (RXR), activated by 9-cis retinoic acid (9-cis RA).
Positive_regulation (activated) of RXR associated with rheumatoid arthritis
16) Confidence 0.02 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 0.89 Pain Relevance 0.14
pharmacological point of view, Yamazaki at al. showed that activation of the RXR/PPAR?
Positive_regulation (activation) of RXR
17) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 0.49 Pain Relevance 0

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