INT135133

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.70
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1I2) signal transduction (NR1I2) nucleus (NR1I2)
Anatomy Link Frequency
CAR 1
body 1
NR1I2 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 1 90.08 High High
anticonvulsant 1 85.92 High High
anesthesia 1 75.00 Quite High
Analgesic 1 66.04 Quite High
nerve block 1 60.72 Quite High
agonist 13 42.60 Quite Low
Potency 1 41.60 Quite Low
Paracetamol 5 25.00 Low Low
Bile 10 21.68 Low Low
Pain 1 7.00 Low Low
Disease Link Frequency Relevance Heat
Rickets 12 98.60 Very High Very High Very High
Sinusitis 63 90.08 High High
Hemorrhage 1 88.72 High High
Disease 2 81.28 Quite High
Hepatocellular Cancer 2 80.00 Quite High
Bladder Cancer 2 76.88 Quite High
Sleep Disorders 5 76.24 Quite High
Infection 21 69.92 Quite High
Congenital Anomalies 7 54.72 Quite High
Rheumatoid Arthritis 6 52.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using reporter gene assays, we show that metamizole is not acting as a direct ligand to either PXR or CAR, suggesting a phenobarbital-like mechanism of induction.
PXR Binding (ligand) of in CAR
1) Confidence 0.42 Published 2007 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 17344806 Disease Relevance 0 Pain Relevance 0.07
The PAR-Q will be interpreted by qualified staff.
PAR-Q Binding (interpreted) of
2) Confidence 0.36 Published 2005 Journal BMC Public Health Section Body Doc Link PMC1351198 Disease Relevance 0 Pain Relevance 0
Thus, theoretically, electrical current flows between the resection loop and the recovery electrode integrated in the outer sleeve of the endoscope, without forming electrical circuit in the patient's body; suggesting possible elimination of the ONR.
ONR Binding (elimination) of in body
3) Confidence 0.32 Published 2010 Journal Masui Section Abstract Doc Link 20229762 Disease Relevance 0.24 Pain Relevance 0.14
Rifampin, the classical activator of CYP3A4, binds to SXR directly.
SXR Binding (binds) of
4) Confidence 0.30 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16632523 Disease Relevance 0.31 Pain Relevance 0
Drugs such as rifampicin bind to SXR, which stimulates 24-hydroxylase activity (Figure 2) thereby causing increased clearance of vitamin D metabolites, vitamin D deficiency and osteomalacia.
SXR Binding (bind) of associated with rickets
5) Confidence 0.29 Published 2008 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC2253556 Disease Relevance 0.37 Pain Relevance 0.04
The diagnosis was based on abnormal findings on SXR and positive microbiological cultures obtained after antral drainage.
SXR Binding (findings) of
6) Confidence 0.26 Published 2005 Journal Crit Care Section Body Doc Link PMC1297630 Disease Relevance 0.78 Pain Relevance 0
In mice and rats, hepatic SULT2A transcription is activated by PXR through the direct binding of PXR to the 5?
PXR Binding (direct) of
7) Confidence 0.13 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.05

General Comments

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