INT135134

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.13
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod)
cytoplasmic membrane-bounded vesicle (Umod) plasma membrane (Umod)
Anatomy Link Frequency
nerve cells 2
Umod (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 8 99.76 Very High Very High Very High
Spinal cord 22 99.68 Very High Very High Very High
Lasting pain 1 96.36 Very High Very High Very High
antagonist 2 94.00 High High
Pain 4 91.84 High High
Neurotransmitter 2 83.16 Quite High
Sciatic nerve 1 76.44 Quite High
Neuropathic pain 1 74.08 Quite High
Analgesic 2 63.60 Quite High
antidepressant 2 62.08 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 5 99.48 Very High Very High Very High
Pain 4 96.36 Very High Very High Very High
Apoptosis 1 78.88 Quite High
Death 1 77.68 Quite High
Nociception 1 74.28 Quite High
Anxiety Disorder 2 62.56 Quite High
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The upregulation of PREG and 3alpha/5alpha-THP biosynthesis might be involved in endogenous mechanisms triggered by neuropathic rats to cope with the chronic pain state. 3alpha/5alpha-THP formation from PREG can also generate PROG, which decreases sensitivity to pain and protects nerve cells against degeneration.
Positive_regulation (upregulation) of Gene_expression (biosynthesis) of THP in nerve cells associated with pain, lasting pain and neuropathic pain
1) Confidence 0.49 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 16632873 Disease Relevance 1.02 Pain Relevance 0.96
These results demonstrate that glycine and gelsemine, acting via Gly-R, upregulate 3alpha,5alpha-THP biosynthesis in the SC.
Positive_regulation (upregulate) of Gene_expression (biosynthesis) of THP associated with spinal cord
2) Confidence 0.49 Published 2008 Journal Neuroscience Section Abstract Doc Link 18367344 Disease Relevance 0.05 Pain Relevance 0.45
Gelsemine, another alkaloid containing the same functional groups as strychnine, increased 3alpha,5alpha-THP synthesis.
Positive_regulation (increased) of Gene_expression (synthesis) of THP
3) Confidence 0.49 Published 2008 Journal Neuroscience Section Abstract Doc Link 18367344 Disease Relevance 0.06 Pain Relevance 0.50

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox