INT135136

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.90
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 1
nerve cells 1
soma 1
thalamus 1
PEE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal horn 24 99.12 Very High Very High Very High
Thalamus 6 96.68 Very High Very High Very High
Lasting pain 3 96.36 Very High Very High Very High
Spinal cord 18 96.08 Very High Very High Very High
Pain 12 91.84 High High
Sciatic nerve 3 85.52 High High
Neuropathic pain 3 74.08 Quite High
Pyramidal cell 27 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 93 99.88 Very High Very High Very High
Neuropathic Pain 15 98.84 Very High Very High Very High
Pain 12 96.36 Very High Very High Very High
Vomiting 32 93.12 High High
Constipation 30 91.28 High High
Nociception 3 89.68 High High
Anaemia 2 84.44 Quite High
Exencephaly /

Neural Tube Defects

6 78.96 Quite High
Apoptosis 3 78.88 Quite High
Death 3 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The parameter Pee represents input from the population of subcortical excitatory neurons (such as those in the thalamus), and ?
Gene_expression (represents) of Pee in thalamus associated with thalamus
1) Confidence 0.19 Published 2010 Journal J Comput Neurosci Section Body Doc Link PMC2880706 Disease Relevance 0.08 Pain Relevance 0.05
The seizure waves occur due to our choice of and a Gaussian Pee distribution with a maximum value of 548.0.
Gene_expression (distribution) of Pee associated with convulsion
2) Confidence 0.19 Published 2010 Journal J Comput Neurosci Section Body Doc Link PMC2880706 Disease Relevance 0.33 Pain Relevance 0
Fig. 7Comparison of the electrode measurement hm (mV, solid) and the mean soma potential he (mV, dashed) at levels of subcortical excitation that cause seizure-like oscillations, Pee?
Gene_expression (oscillations) of Pee in soma associated with convulsion
3) Confidence 0.19 Published 2010 Journal J Comput Neurosci Section Body Doc Link PMC2880706 Disease Relevance 0.27 Pain Relevance 0
A new prescription prenatal micronutrient supplement PregVit® has recently been introduced into the Canadian Market aiming to address these issues: PregVit®, taken twice daily, contains less elemental iron (35 mg) than many other prenatal supplements.
Gene_expression (introduced) of PregVit
4) Confidence 0.06 Published 2006 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1481554 Disease Relevance 0.62 Pain Relevance 0
It is likely that the higher dose of zinc, found in Materna® versus PregVit® plus manganese, (which is not included in PregVit®) all interfere with the absorption of iron.
Gene_expression (found) of PregVit
5) Confidence 0.06 Published 2006 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1481554 Disease Relevance 0.14 Pain Relevance 0
The upregulation of PREG and 3alpha/5alpha-THP biosynthesis might be involved in endogenous mechanisms triggered by neuropathic rats to cope with the chronic pain state. 3alpha/5alpha-THP formation from PREG can also generate PROG, which decreases sensitivity to pain and protects nerve cells against degeneration.
Gene_expression (biosynthesis) of PREG in nerve cells associated with pain, lasting pain and neuropathic pain
6) Confidence 0.02 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 16632873 Disease Relevance 1.02 Pain Relevance 0.96
P450scc is the key enzyme catalyzing the conversion of cholesterol (CHOL) into PREG, the rate-limiting step in the biosynthesis of all classes of steroids.
Gene_expression (biosynthesis) of PREG
7) Confidence 0.02 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 16632873 Disease Relevance 0.32 Pain Relevance 0.62
Incubation of spinal tissue homogenates with [3H]CHOL revealed that the amount of newly synthesized [3H]PREG from [3H]CHOLwas 80% higher in the DH of neuropathic rats.
Gene_expression (synthesized) of PREG in spinal associated with neuropathic pain and dorsal horn
8) Confidence 0.01 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 16632873 Disease Relevance 0.91 Pain Relevance 0.90

General Comments

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