INT135158

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C9) oxidoreductase activity (CYP2C9) endoplasmic reticulum (CYP2C9)
Anatomy Link Frequency
hearts 3
CYP2C9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 6 85.68 High High
Myocardial Infarction 27 80.00 Quite High
Cardiovascular Disease 9 30.08 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Fibrosis 3 5.00 Very Low Very Low Very Low
Hypertension 3 5.00 Very Low Very Low Very Low
Coronary Heart Disease 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CYP4A11, CYP2E1, CYP1A1 and CYP2C8 mRNAs were present at an intermediate level while CYP2B6 and CYP2C9 mRNAs were present at very low levels in some of the analyzed hearts.


Spec (analyzed) Transcription (present) of CYP2C9 in hearts
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.08 Pain Relevance 0
It is noteworthy that CYP2C9 and CYP2B6 mRNAs were only detected in a small number of hearts.
Transcription (detected) of CYP2C9 in hearts
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.22 Pain Relevance 0
CYP2C9*3 were detected in all the three races with the Indians having the highest frequency of CYP2C9*3 (9.7%).
Transcription (detected) of CYP2C9
3) Confidence 0.53 Published 2006 Journal J Clin Pharm Ther Section Body Doc Link 16635054 Disease Relevance 0 Pain Relevance 0
Other CYP450 mRNAs of importance were CYP4A11, CYP2E1, CYP1A1 and CYP2C8 mRNAs while CYP2B6 and CYP2C9 mRNAs were present at low levels in only some of the hearts analyzed.
Transcription (present) of CYP2C9 in hearts
4) Confidence 0.48 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001885 Disease Relevance 0.08 Pain Relevance 0

General Comments

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