INT135169

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 12.48
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
respiratory 1
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 164 99.46 Very High Very High Very High
ischemia 52 90.88 High High
imagery 210 81.32 Quite High
cytokine 7 67.72 Quite High
analgesia 1 65.44 Quite High
Paracetamol 15 50.00 Quite Low
ketamine 16 43.16 Quite Low
fibrosis 9 33.92 Quite Low
withdrawal 18 31.12 Quite Low
Hippocampus 3 27.40 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 337 100.00 Very High Very High Very High
Infection 627 99.76 Very High Very High Very High
Targeted Disruption 176 99.76 Very High Very High Very High
INFLAMMATION 177 99.46 Very High Very High Very High
Respiratory Syncytial Virus 693 98.04 Very High Very High Very High
Coronary Heart Disease 72 97.28 Very High Very High Very High
Sprains And Strains 28 95.76 Very High Very High Very High
Cancer 181 94.36 High High
Death 30 93.48 High High
Viral Infection 21 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HBO2 increased HIF-1alpha DNA binding 5.7 (+/- 1.2)-fold relative to controls (p < 0.01); however, a parallel increase in HIF functional transcriptional activity did not occur.
HIF-1alpha Binding (binding) of
1) Confidence 0.47 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16636360 Disease Relevance 0 Pain Relevance 0
HIF-1alpha DNA-binding and transcriptional activity were assessed.
HIF-1alpha Binding (binding) of
2) Confidence 0.47 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16636360 Disease Relevance 0 Pain Relevance 0
HBO2 increases HIF-1alpha protein levels and DNA binding without a corresponding increase in transcriptional activity.


HIF-1alpha Binding (binding) of
3) Confidence 0.47 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16636360 Disease Relevance 0 Pain Relevance 0
Chromatin immunoprecipitation identified direct binding of HIF-1?
HIF-1 Binding (binding) of
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.06 Pain Relevance 0
It has also been shown that enhanced transcriptional activity, due to association of HIF-1?
HIF-1 Binding (association) of
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.26 Pain Relevance 0
For microarray analysis, probes were generated from reverse transcription of 20 µg of pooled RNA for each of tTA and tTA/HIF-1?
HIF-1 Binding (each) of
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.05 Pain Relevance 0
Another oxygen dependent control acting to limit the activity of HIF-1?
HIF-1 Binding (activity) of
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.32 Pain Relevance 0
Initially, HIF-1?
HIF-1 Binding (Initially) of
8) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.17 Pain Relevance 0
This also allows us to investigate the effects of enhancing HIF-1 activity in the adult animal, avoiding any developmental effects, and modeling the potential use of HIF-1?
HIF-1 Binding (activity) of
9) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.49 Pain Relevance 0.05
The response to hypoxia in tissues is regulated by the heterodimeric transcription factor Hypoxia Inducible Factor-1 (HIF-1).


Hypoxia Inducible Factor-1 Binding (heterodimeric) of associated with hypoxia
10) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908132 Disease Relevance 0.39 Pain Relevance 0
The response to hypoxia in tissues is regulated by the heterodimeric transcription factor Hypoxia Inducible Factor-1 (HIF-1).


HIF-1 Binding (heterodimeric) of associated with hypoxia
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908132 Disease Relevance 0.39 Pain Relevance 0
is stable and can bind to HIF-1?
HIF-1 Binding (bind) of
12) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.35 Pain Relevance 0
VHL cannot bind HIF-1 under hypoxic conditions, leading to stabilization of HIF-1 and downstream signaling [58].
HIF-1 Neg (cannot) Binding (bind) of associated with hypoxia
13) Confidence 0.16 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.68 Pain Relevance 0.12
This HRE is the HIF-1 target binding site [59].
HIF-1 Binding (binding) of
14) Confidence 0.16 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.84 Pain Relevance 0.10
In addition, recent studies identified a role for HIF-1?
HIF-1 Binding (role) of
15) Confidence 0.14 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2556398 Disease Relevance 1.19 Pain Relevance 0.09
For example, HIF-1?
HIF-1 Binding (example) of
16) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.87 Pain Relevance 0.16
Other studies have identified a crosstalk between viral genes and the HIF-1?
HIF-1 Binding (crosstalk) of
17) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.25 Pain Relevance 0
Under hypoxic conditions, hydroxylation is inhibited and the VHL protein does not bind to HIF-1, eventually leading to stabilization of the alpha-subunit, heterodymerization, nuclear translocation and transcription of HIF-dependent genes.
HIF-1 Neg (not) Binding (bind) of associated with hypoxia
18) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.60 Pain Relevance 0
For example, binding of HIF-1 to consensus domains in the erythropoietin promoter results in the transcriptional induction of HIF-1-bearing gene promoters [8].
HIF-1 Binding (binding) of
19) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.62 Pain Relevance 0
Based on studies showing that respiratory syncytial virus (RSV) is among the most potent biological stimuli to induce an inflammatory milieu, we hypothesized a role of HIF-1?
HIF-1 Binding (role) of in respiratory associated with inflammation and respiratory syncytial virus
20) Confidence 0.14 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2556398 Disease Relevance 1.59 Pain Relevance 0.10

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