INT135170

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2011
Negated 5
Speculated 0
Reported most in Body
Documents 86
Total Number 86
Disease Relevance 99.40
Pain Relevance 6.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
endothelial cells 4
Plasma 1
smooth muscle 1
nucleus 1
adult heart 1
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1258 99.28 Very High Very High Very High
imagery 683 98.44 Very High Very High Very High
ischemia 92 98.28 Very High Very High Very High
COX2 350 94.64 High High
cytokine 49 92.92 High High
Catecholamine 5 91.08 High High
Inflammatory response 130 90.64 High High
Central nervous system 12 88.60 High High
fibrosis 11 87.44 High High
cva 20 85.68 High High
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 4951 100.00 Very High Very High Very High
Infection 4487 100.00 Very High Very High Very High
Hypoxia 1534 100.00 Very High Very High Very High
Pneumonia 209 99.80 Very High Very High Very High
Disease 342 99.56 Very High Very High Very High
Viral Infection 151 99.44 Very High Very High Very High
INFLAMMATION 1347 99.28 Very High Very High Very High
Sepsis 328 98.88 Very High Very High Very High
Solid Tumor 7 98.86 Very High Very High Very High
Heterotopic Ossification 4 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APAP poisoning increases HIF-1alpha protein levels and functional activity.
Positive_regulation (increases) of HIF-1alpha
1) Confidence 0.67 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16636360 Disease Relevance 0 Pain Relevance 0
Plasma alanine aminotransferase activity was measured, and hepatic HIF-1alpha induction was determined by Western blot.
Positive_regulation (induction) of HIF-1alpha in Plasma
2) Confidence 0.67 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16636360 Disease Relevance 0 Pain Relevance 0
The up-regulation of hypoxia-inducible factor-1 (HIF-1) leads to an increased downstream expression of HIF-1 target genes, such as TGFbeta and iNOS.
Positive_regulation (up-regulation) of hypoxia-inducible factor-1 associated with hypoxia
3) Confidence 0.49 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18599338 Disease Relevance 1.52 Pain Relevance 0.10
The up-regulation of hypoxia-inducible factor-1 (HIF-1) leads to an increased downstream expression of HIF-1 target genes, such as TGFbeta and iNOS.
Positive_regulation (up-regulation) of HIF-1 associated with hypoxia
4) Confidence 0.49 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18599338 Disease Relevance 1.52 Pain Relevance 0.10
Mice were taken off doxycycline for 7 days, at which time three hearts were harvested to assess activation of HIF-1?
Positive_regulation (activation) of HIF-1 in hearts
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.08 Pain Relevance 0.07
Deletion of Prolyl Hydroxylase 2 (PHD2), the enzyme thought to be most important for HIF-1?
Positive_regulation (important) of HIF-1
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.96 Pain Relevance 0.07
The destabilization of HIF-1?
Positive_regulation (destabilization) of HIF-1
7) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.35 Pain Relevance 0
We then evaluated the resulting cardiac phenotype and explored the underlying biochemical, physiological, and transcriptional results of HIF-1 stabilization.
Positive_regulation (stabilization) of HIF-1
8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.77 Pain Relevance 0.08
This also allows us to investigate the effects of enhancing HIF-1 activity in the adult animal, avoiding any developmental effects, and modeling the potential use of HIF-1?
Positive_regulation (enhancing) of HIF-1
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.49 Pain Relevance 0.05
These results provide a deeper understanding of transcriptional activity of HIF in the heart, and show that enhanced HIF-1 activity is sufficient to cause contractile dysfunction in the adult heart.
Positive_regulation (enhanced) of HIF-1 in adult heart
10) Confidence 0.29 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908132 Disease Relevance 0.35 Pain Relevance 0
-PPN cDNA was subcloned into the tetracycline-responsive pUHG-10 vector to generate the pUHG-HIF-1?
Positive_regulation (generate) of HIF-1
11) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.49 Pain Relevance 0
Constitutive normoxic induction of the HIF-1?
Positive_regulation (induction) of HIF-1
12) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.43 Pain Relevance 0
Similarly, Western blot analysis confirmed an approximately 8-fold increase in HIF-1?
Positive_regulation (increase) of HIF-1
13) Confidence 0.26 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2556398 Disease Relevance 2.04 Pain Relevance 0.08
stabilization and induction of HIF-1?
Positive_regulation (stabilization) of HIF-1
14) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.03 Pain Relevance 0.04
Taken together, these studies demonstrate induction of HIF-1?
Positive_regulation (induction) of HIF-1
15) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.80 Pain Relevance 0.08
during infection with human pathogenic bacteria [54].Similarly, previous studies on viral infections with RSV have demonstrated induction of HIF-1?
Positive_regulation (induction) of HIF-1 associated with viral infection, respiratory syncytial virus and infection
16) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.27 Pain Relevance 0
These studies revealed an 8.2±5.2-fold increase in HIF-1?
Positive_regulation (increase) of HIF-1
17) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.82 Pain Relevance 0
Such studies have led to an understanding that induction of HIF-1 responsive genes drives altered cellular metabolism, increased vascular mass and diameter and increased oxygen carrying capacity of the blood; all events which are conducive to an adaptive response to diminished oxygen supply [1], [14]–[16].
Positive_regulation (induction) of HIF-1 in blood
18) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.45 Pain Relevance 0.07
in transcriptional induction of HIF-1?
Positive_regulation (induction) of HIF-1
19) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.01 Pain Relevance 0.03
These studies revealed that KSHV infection of endothelial cells induces mRNA of HIF-1?
Positive_regulation (induces) of HIF-1 in endothelial cells associated with infection
20) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.25 Pain Relevance 0

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