INT135171

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 16.95
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
intestinal epithelium 2
nucleus 2
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 111 99.76 Very High Very High Very High
Paracetamol 10 99.72 Very High Very High Very High
Inflammatory response 72 95.88 Very High Very High Very High
Pain 11 90.64 High High
Catecholamine 10 89.60 High High
COX2 42 78.92 Quite High
Inflammation 172 68.24 Quite High
cytokine 16 24.44 Low Low
tolerance 2 14.28 Low Low
chemokine 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 594 100.00 Very High Very High Very High
Infection 536 100.00 Very High Very High Very High
Hypoxia 210 100.00 Very High Very High Very High
Disease 55 99.90 Very High Very High Very High
Toxicity 2 99.90 Very High Very High Very High
Cv Unclassified Under Development 126 99.76 Very High Very High Very High
Targeted Disruption 25 99.76 Very High Very High Very High
Cytomegalovirus Infection 6 97.28 Very High Very High Very High
Heterotopic Ossification 6 96.64 Very High Very High Very High
Hepatotoxicity 4 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A new mouse model of Peyronie's disease: an increased expression of hypoxia-inducible factor-1 target genes during the development of penile changes.
Positive_regulation (increased) of Gene_expression (expression) of hypoxia-inducible factor-1 associated with hypoxia and disease
1) Confidence 0.68 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Title Doc Link 18599338 Disease Relevance 1.38 Pain Relevance 0.14
APAP-only, HBO2-only, and APAP+HBO2 treatments all increased HIF-1alpha expression relative to shams (p = 0.02, p = 0.02, and p < 0.01, respectively).
Positive_regulation (increased) of Gene_expression (expression) of HIF-1alpha
2) Confidence 0.67 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16636360 Disease Relevance 0 Pain Relevance 0
Hyperbaric oxygen reduces acetaminophen toxicity and increases HIF-1alpha expression.
Positive_regulation (increases) of Gene_expression (expression) of HIF-1alpha associated with toxicity and paracetamol
3) Confidence 0.67 Published 2006 Journal Acad Emerg Med Section Title Doc Link 16636360 Disease Relevance 0.47 Pain Relevance 0.48
The up-regulation of hypoxia-inducible factor-1 (HIF-1) leads to an increased downstream expression of HIF-1 target genes, such as TGFbeta and iNOS.
Positive_regulation (increased) of Gene_expression (expression) of HIF-1 associated with hypoxia
4) Confidence 0.49 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18599338 Disease Relevance 1.50 Pain Relevance 0.09
The up-regulation of hypoxia-inducible factor-1 (HIF-1) leads to an increased downstream expression of HIF-1 target genes, such as TGFbeta and iNOS.
Positive_regulation (leads) of Gene_expression (expression) of HIF-1 associated with hypoxia
5) Confidence 0.49 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18599338 Disease Relevance 1.50 Pain Relevance 0.09
This plasmid was used for transfection of tissue culture cells, as well as for production of an adenoviral vector encoding HIF-1?
Positive_regulation (transfection) of Gene_expression (production) of HIF-1
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.57 Pain Relevance 0.03
We have created a transgenic model that allows the regulated expression of constitutively active HIF-1?
Positive_regulation (allows) of Gene_expression (expression) of HIF-1 associated with targeted disruption
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.32 Pain Relevance 0
These studies revealed significant induction of HIF-1-target genes (VEGF, CD73 or FN1) in control cells, while these responses were abolished in HIF-1?
Positive_regulation (induction) of Gene_expression (genes) of HIF-1-target
8) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.06 Pain Relevance 0.03
accumulates in the cytosole and the nucleus of infected pulmonary epithelia, suggesting HIF-1?
Positive_regulation (accumulates) of Gene_expression (suggesting) of HIF-1 in nucleus
9) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.87 Pain Relevance 0.06
Taken together, these data reveal that during RSV infection, HIF-1?
Positive_regulation (during) of Gene_expression (infection) of HIF-1 associated with infection and respiratory syncytial virus
10) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.70 Pain Relevance 0.06
in the observed induction of HIF-dependent genes induction during RSV infection, we next pursued HIF-1?
Positive_regulation (induction) of Gene_expression (pursued) of HIF-1 associated with infection and respiratory syncytial virus
11) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.67 Pain Relevance 0.07
in the intestinal epithelium showed a significantly higher susceptibility to orogastric Y enterocolitica infections, suggesting HIF-1?
Positive_regulation (showed) of Gene_expression (suggesting) of HIF-1 in intestinal epithelium associated with infection
12) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.48 Pain Relevance 0.03
protein in control transfected cells in conjunction with attenuated HIF-1 ?
Positive_regulation (transfected) of Gene_expression (conjunction) of HIF-1
13) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.17 Pain Relevance 0.03
protein stability and activate HIF-1 inducible gene expression [45].
Positive_regulation (activate) of Gene_expression (expression) of HIF-1
14) Confidence 0.10 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2883961 Disease Relevance 0.87 Pain Relevance 0.13
In a Phase I dose-escalating trial, transfection of HIF-1 alpha into CLI patients demonstrated tolerability with some indication of efficacy [27].
Positive_regulation (transfection) of Gene_expression (transfection) of HIF-1 alpha associated with ischemia
15) Confidence 0.09 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.52 Pain Relevance 0.15
protein stability and activate HIF-1 inducible gene expression [45].
Positive_regulation (inducible) of Gene_expression (expression) of HIF-1
16) Confidence 0.08 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2883961 Disease Relevance 0.87 Pain Relevance 0.13

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