INT135172

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 2006
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 56
Total Number 60
Disease Relevance 46.49
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
hearts 3
liver 2
cardiomyocyte 1
intestinal epithelium 1
nucleus 1
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 231 99.76 Very High Very High Very High
Paracetamol 35 99.52 Very High Very High Very High
Inflammation 541 99.28 Very High Very High Very High
withdrawal 45 98.12 Very High Very High Very High
Inflammatory response 67 95.88 Very High Very High Very High
Pain 15 90.64 High High
COX2 175 90.56 High High
Catecholamine 5 89.24 High High
imagery 224 84.64 Quite High
Inflammatory stimuli 1 65.84 Quite High
Disease Link Frequency Relevance Heat
Infection 2230 100.00 Very High Very High Very High
Hypoxia 960 100.00 Very High Very High Very High
Repression 175 100.00 Very High Very High Very High
Respiratory Syncytial Virus 2475 99.98 Very High Very High Very High
Cv Unclassified Under Development 405 99.76 Very High Very High Very High
Disease 126 99.70 Very High Very High Very High
Toxicity 7 99.70 Very High Very High Very High
Targeted Disruption 300 99.60 Very High Very High Very High
Poisoning 3 99.42 Very High Very High Very High
INFLAMMATION 581 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A new mouse model of Peyronie's disease: an increased expression of hypoxia-inducible factor-1 target genes during the development of penile changes.
Gene_expression (expression) of hypoxia-inducible factor-1 associated with hypoxia and disease
1) Confidence 0.76 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Title Doc Link 18599338 Disease Relevance 1.38 Pain Relevance 0.14
The up-regulation of hypoxia-inducible factor-1 (HIF-1) leads to an increased downstream expression of HIF-1 target genes, such as TGFbeta and iNOS.
Gene_expression (expression) of HIF-1 associated with hypoxia
2) Confidence 0.76 Published 2008 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18599338 Disease Relevance 1.48 Pain Relevance 0.09
The authors further evaluated the effects of APAP poisoning and HBO2 on the expression and function of hypoxia-inducible factor 1-alpha (HIF-1alpha) in an effort to further describe the mechanisms of APAP-induced hepatotoxicity.
Gene_expression (expression) of HIF-1alpha associated with paracetamol, hypoxia, hepatotoxicity and poisoning
3) Confidence 0.75 Published 2006 Journal Acad Emerg Med Section Abstract Doc Link 16636360 Disease Relevance 0.47 Pain Relevance 0.46
Immunohistochemical analyses also demonstrated that AA could reduce the appearance of necrosis regions as well as caspase-3 and hypoxia inducible factor-1alpha (HIF-1alpha) expression in liver tissue.
Gene_expression (expression) of HIF-1alpha in liver associated with necrosis and hypoxia
4) Confidence 0.75 Published 2010 Journal Phytomedicine Section Abstract Doc Link 19836221 Disease Relevance 0.60 Pain Relevance 0.61
Histopathological and immunohistochemical analyses also demonstrated that SDS could reduce the appearance of necrosis regions as well as caspase-3 and hypoxia inducible factor-1alpha (HIF-1alpha) expression in liver tissue.
Gene_expression (expression) of HIF-1alpha in liver associated with necrosis and hypoxia
5) Confidence 0.75 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.63 Pain Relevance 0.91
APAP-only, HBO2-only, and APAP+HBO2 treatments all increased HIF-1alpha expression relative to shams (p = 0.02, p = 0.02, and p < 0.01, respectively).
Gene_expression (expression) of HIF-1alpha
6) Confidence 0.75 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16636360 Disease Relevance 0 Pain Relevance 0
Hyperbaric oxygen reduces acetaminophen toxicity and increases HIF-1alpha expression.
Gene_expression (expression) of HIF-1alpha associated with toxicity and paracetamol
7) Confidence 0.75 Published 2006 Journal Acad Emerg Med Section Title Doc Link 16636360 Disease Relevance 0.47 Pain Relevance 0.48
We have created a strain of mice with inducible cardiomyocyte-specific expression of a mutated, oxygen-stable, form of HIF-1?.
Gene_expression (expression) of HIF-1 in cardiomyocyte associated with sprains and strains
8) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908132 Disease Relevance 0.38 Pain Relevance 0
We examined both tTA/HIF-1?
Spec (examined) Gene_expression (/) of HIF-1
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.09 Pain Relevance 0.04
This plasmid was used for transfection of tissue culture cells, as well as for production of an adenoviral vector encoding HIF-1?
Gene_expression (production) of HIF-1
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.56 Pain Relevance 0.03
Importantly, tTA/HIF-1?
Gene_expression (Importantly) of HIF-1
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.22 Pain Relevance 0.03
cDNA with alanine substitutions at Pro402, Pro564, and Asn803 (denoted HIF-1?
Gene_expression (denoted) of HIF-1
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.21 Pain Relevance 0.03
A transgene containing the human HIF-1?
Gene_expression (containing) of HIF-1
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.21 Pain Relevance 0.03
Importantly, tTA/HIF-1?
Gene_expression (/) of HIF-1
14) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.22 Pain Relevance 0.03
The HA-tagged HIF-1?
Gene_expression (tagged) of HIF-1
15) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.53 Pain Relevance 0.03
We examined both tTA/HIF-1?
Spec (examined) Gene_expression (examined) of HIF-1
16) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.09 Pain Relevance 0.04
Echocardiographic analysis of tTA/HIF-1?
Gene_expression (/) of HIF-1
17) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.15 Pain Relevance 0.10
Echocardiographic analysis of tTA/HIF-1?
Gene_expression (analysis) of HIF-1
18) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.15 Pain Relevance 0.10
For microarray analysis, probes were generated from reverse transcription of 20 µg of pooled RNA for each of tTA and tTA/HIF-1?
Gene_expression (/) of HIF-1
19) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.05 Pain Relevance 0
This prevents the HIF-1?
Neg (prevents) Gene_expression (prevents) of HIF-1
20) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.30 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox