INT135180

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.73
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, TNFSF11) extracellular region (IL1B, TNFSF11) cell differentiation (TNFSF11)
aging (IL1B) intracellular (TNFSF11) response to stress (TNFSF11)
Anatomy Link Frequency
HPDL 4
osteoblasts 3
chondrocytes 1
IL1B (Homo sapiens)
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 85.40 High High
Analgesic 2 75.80 Quite High
Snapping jaw 16 64.64 Quite High
Pain 4 57.68 Quite High
cytokine 12 57.00 Quite High
COX2 4 25.00 Low Low
Osteoarthritis 2 21.44 Low Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 2 92.28 High High
Cancer 2 91.92 High High
INFLAMMATION 14 85.40 High High
Hypercalcemia 6 84.08 Quite High
Dental Plaque 2 82.72 Quite High
Disease 2 80.16 Quite High
Periodontal Disease 2 78.92 Quite High
Bacterial Respiratory Disease 2 74.48 Quite High
Osteoporosis 2 73.76 Quite High
Arthropathy 8 66.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we investigate the effects of baicalin on RANKL protein production and messenger RNA (mRNA) expression induced by IL-1beta in cultured HPDL cells.
IL-1beta Spec (investigate) Positive_regulation (induced) of Gene_expression (production) of RANKL protein in HPDL
1) Confidence 0.76 Published 2006 Journal Pharmacology Section Abstract Doc Link 16636611 Disease Relevance 0.66 Pain Relevance 0.11
RESULTS: The expression of RANKL at mRNA and protein levels in HPDL cells was stimulated by IL-1beta.
IL-1beta Positive_regulation (stimulated) of Gene_expression (expression) of RANKL in HPDL
2) Confidence 0.55 Published 2006 Journal Pharmacology Section Body Doc Link 16636611 Disease Relevance 0 Pain Relevance 0
IL-1 increases RANKL expression in osteoblasts and chondrocytes [1, 10].
IL-1 Positive_regulation (increases) of Gene_expression (expression) of RANKL in osteoblasts
3) Confidence 0.52 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.53 Pain Relevance 0.32
IL-1 increases RANKL expression in osteoblasts and chondrocytes [1, 10].
IL-1 Positive_regulation (increases) of in chondrocytes Gene_expression (expression) of RANKL in osteoblasts
4) Confidence 0.18 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.53 Pain Relevance 0.32

General Comments

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