INT135181

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 5
Total Number 14
Disease Relevance 6.98
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TNFSF11) extracellular space (TNFSF11) extracellular region (TNFSF11)
plasma membrane (TNFSF11) intracellular (TNFSF11) response to stress (TNFSF11)
Anatomy Link Frequency
chondrocytes 4
cartilage 4
stromal cells 3
HPDL 2
osteoblasts 1
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 99.54 Very High Very High Very High
Osteoarthritis 82 99.04 Very High Very High Very High
cytokine 52 93.84 High High
Analgesic 1 76.72 Quite High
Inflammation 41 76.16 Quite High
Pain 20 72.60 Quite High
Paracetamol 1 26.64 Quite Low
COX2 2 25.00 Low Low
Snapping jaw 48 24.12 Low Low
metalloproteinase 40 23.72 Low Low
Disease Link Frequency Relevance Heat
Osteolysis 32 99.46 Very High Very High Very High
INFLAMMATION 46 99.40 Very High Very High Very High
Osteoarthritis 80 99.04 Very High Very High Very High
Cancer 196 98.32 Very High Very High Very High
Knee Osteoarthritis 2 98.32 Very High Very High Very High
Necrosis 6 93.20 High High
Metastasis 218 93.00 High High
Osteoporosis 112 92.08 High High
Hypercalcemia 36 85.00 Quite High
Prostate Cancer 114 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis.
Regulation (modulate) of Gene_expression (synthesis) of RANKL in cartilage associated with inflammation, knee osteoarthritis and osteoarthritis
1) Confidence 0.61 Published 2010 Journal Arthritis Rheum. Section Title Doc Link 20112374 Disease Relevance 0.47 Pain Relevance 0.31
showed the same effect for the expression of RANKL, M-CSF, and OPG for any culture period, while the control value changed in the long-term culture.
Regulation (changed) of Gene_expression (expression) of RANKL
2) Confidence 0.46 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
In the present study, we explored in human subchondral bone whether CS and GS or both together affect certain bone biomarkers, OPG and RANKL levels, and pro-resorptive activity.
Spec (whether) Regulation (affect) of Gene_expression (levels) of RANKL
3) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 1.08 Pain Relevance 0.32
In this study we investigate the effects of baicalin on RANKL protein production and messenger RNA (mRNA) expression induced by IL-1beta in cultured HPDL cells.
Spec (investigate) Regulation (effects) of Gene_expression (production) of RANKL protein in HPDL
4) Confidence 0.44 Published 2006 Journal Pharmacology Section Abstract Doc Link 16636611 Disease Relevance 0.67 Pain Relevance 0.11
As a result, OPG and RANKL expression increased with IL-1?
Regulation (with) of Gene_expression (expression) of RANKL
5) Confidence 0.34 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.06 Pain Relevance 0.03
, RANKL, M-CSF, and OPG gene expression was unaffected by the presence of celecoxib.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of RANKL
6) Confidence 0.34 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
on the expression of OPG and RANKL; whereas it did not affect the IL-1?
Regulation (on) of Gene_expression (expression) of RANKL
7) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
The aim of this study was to examine whether nonsteroidal antiinflammatory drug (NSAID) treatment modulates the synthesis of OPG and RANKL in the cartilage of patients with OA, and to investigate whether prostaglandin E(2) (PGE(2)) modifies this system in human OA chondrocytes in culture.
Spec (whether) Regulation (modulates) of Gene_expression (synthesis) of RANKL in cartilage associated with inflammation, cinod and osteoarthritis
8) Confidence 0.27 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20112374 Disease Relevance 0.63 Pain Relevance 0.33
Osteolysis is characterized by an increase in the ratio of RANKL to OPG; tumor-secreted factors that have been implicated in osteolysis increase this ratio by up-regulating the RANKL expression on osteoblasts/stromal cells or by downregulating OPG secretion [26,34,41].
Regulation (regulating) of Gene_expression (expression) of RANKL in stromal cells associated with cancer and osteolysis
9) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.41 Pain Relevance 0.05
Analysis of the effects of osteopontin over-expression on cell morphology and RANKL expression in PC3 cell lines
Regulation (effects) of Gene_expression (expression) of RANKL
10) Confidence 0.20 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 0.25 Pain Relevance 0
not only affected the expression of RANKL, M-CSF, and OPG in chondrocytes, but may also affect the course of cell differentiation.
Regulation (affected) of Gene_expression (expression) of RANKL in chondrocytes
11) Confidence 0.20 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
not only affected the expression of RANKL, M-CSF, and OPG in chondrocytes, but may also affect the course of cell differentiation.
Spec (may) Regulation (affect) of Gene_expression (expression) of RANKL in chondrocytes
12) Confidence 0.20 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
3 signaling may have a role in the expression of RANKL.
Spec (may) Regulation (role) of Gene_expression (expression) of RANKL
13) Confidence 0.09 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1828067 Disease Relevance 1.01 Pain Relevance 0.07
Osteolysis is characterized by an increase in the ratio of RANKL to OPG; tumor-secreted factors that have been implicated in osteolysis increase this ratio by up-regulating the RANKL expression on osteoblasts/stromal cells or by downregulating OPG secretion [26,34,41].
Regulation (regulating) of in osteoblasts Gene_expression (expression) of RANKL in stromal cells associated with cancer and osteolysis
14) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.41 Pain Relevance 0.05

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