INT135188

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.72
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TNFSF11) extracellular space (TNFSF11) extracellular region (TNFSF11)
plasma membrane (TNFSF11) intracellular (TNFSF11) response to stress (TNFSF11)
Anatomy Link Frequency
osteoblasts 1
fibroblast 1
HPDL 1
TNFSF11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 132 96.44 Very High Very High Very High
Bioavailability 2 77.84 Quite High
Snapping jaw 2 50.00 Quite Low
COX2 4 10.00 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 132 96.44 Very High Very High Very High
Osteoporosis 32 76.24 Quite High
Temporomandibular Joint Disorders 1 50.00 Quite Low
Hypercalcemia 16 26.92 Quite Low
Disease 14 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the OPG and RANKL system, our data revealed that CS can modulate the expression of these molecules by increasing OPG and decreasing the gene expression level of RANKL, thereby increasing the mRNA ratio of OPG/RANKL.
Transcription (ratio) of RANKL
1) Confidence 0.59 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.06 Pain Relevance 0.07
g/mL), or both together on human OA subchondral bone osteoblasts, in the presence or absence of 1,25(OH)2D3 (vitamin D3) (50 nM), was determined on the bone biomarkers alkaline phosphatase and osteocalcin, on the expression (mRNA) and production (enzyme-linked immunosorbent assay) of bone remodelling factors OPG and RANKL, and on the pro-resorptive activity of these cells.
Transcription (expression) of RANKL in osteoblasts associated with osteoarthritis
2) Confidence 0.59 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246236 Disease Relevance 0.66 Pain Relevance 0.29
Using these fibroblastic cells, we examined fibroblast markers using immunocytochemical staining and analyzed the receptor activator of nuclear-factor-kappaB ligand (RANKL) mRNA levels.
Transcription (levels) of RANKL in fibroblast
3) Confidence 0.53 Published 2007 Journal Osteoarthr. Cartil. Section Body Doc Link 16979913 Disease Relevance 0 Pain Relevance 0
RESULTS: The expression of RANKL at mRNA and protein levels in HPDL cells was stimulated by IL-1beta.
Transcription (mRNA) of RANKL in HPDL
4) Confidence 0.52 Published 2006 Journal Pharmacology Section Body Doc Link 16636611 Disease Relevance 0 Pain Relevance 0
The mRNA of RANKL, osteoprotegerin (OPG) and cyclooxygenase-2 (COX-2) were measured by semiquantitative reverse transcription-polymerase chain reaction.
Transcription (mRNA) of RANKL
5) Confidence 0.52 Published 2006 Journal Pharmacology Section Body Doc Link 16636611 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox