INT13520

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 32.65
Pain Relevance 6.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB4) signal transduction (HLA-DRB4) Golgi apparatus (HLA-DRB4)
endoplasmic reticulum (HLA-DRB4) plasma membrane (HLA-DRB4)
Anatomy Link Frequency
leukocyte 2
liver 1
CAR 1
Juvenile 1
T-cell 1
HLA-DRB4 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 34 100.00 Very High Very High Very High
rheumatoid arthritis 197 99.92 Very High Very High Very High
Osteoarthritis 46 99.80 Very High Very High Very High
Inflammation 258 99.52 Very High Very High Very High
corticosteroid 7 98.32 Very High Very High Very High
Arthritis 214 97.76 Very High Very High Very High
cytokine 65 92.20 High High
Pain 21 91.44 High High
psoriasis 6 90.40 High High
Paracetamol 2 86.12 High High
Disease Link Frequency Relevance Heat
Low Back Pain 36 100.00 Very High Very High Very High
Death 35 100.00 Very High Very High Very High
Rheumatoid Arthritis 218 99.92 Very High Very High Very High
Apoptosis 172 99.92 Very High Very High Very High
Osteoarthritis 45 99.80 Very High Very High Very High
Disease 371 99.76 Very High Very High Very High
Pemphigoid 60 99.76 Very High Very High Very High
Epstein-barr Virus 4 99.64 Very High Very High Very High
Syndrome 68 99.60 Very High Very High Very High
INFLAMMATION 265 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, he was found to carry human leukocyte antigen DR4, which has been reported to be associated with these inflammatory conditions.
leukocyte antigen DR4 Binding (associated) of in leukocyte associated with inflammation
1) Confidence 0.42 Published 2005 Journal Mod Rheumatol Section Abstract Doc Link 17029064 Disease Relevance 0.71 Pain Relevance 0.14
Juvenile arthritis (JA) is a term that covers a number of different disease entities, of which only three present with significant Human Leukocyte Antigen (HLA) associations. (1) Pauciarticular JA with late onset and a strong male proponderance is associated with HLA-B27 and represents the group of juvenile spondyloarthropathies related to adult ankylosing spondylitis. (2) Early onset pauciarticular JA with a preponderance of females and a frequent occurance of chronic iridocyclitis and the frequent presence of anti-nuclear antibodies is associated with alleles from three different regions of the HLA system: HLA-A2, which shows a very strong correlation with early age of onset; DR8, DR11 and DR12 as well as DQA1*0401, *0501, *0601 and finally DPB1*0201.
DR12 Binding (associated) of in Juvenile associated with iridocyclitis, spinal inflammation, disease and arthritis
2) Confidence 0.34 Published 1998 Journal Baillieres Clin Rheumatol Section Abstract Doc Link 9890094 Disease Relevance 0.96 Pain Relevance 0.43
We felt that such problems might explain the conflicting opinions as to the association between RF and HLA-DR4 in patients with RA.
HLA-DR4 Spec (might) Binding (association) of associated with rheumatoid arthritis
3) Confidence 0.30 Published 1988 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 3266362 Disease Relevance 1.01 Pain Relevance 0.51
The receptor binds to DR3, DR4, DR5, ER6 and ER8 motifs of the general nuclear receptor binding site, which have been identified in enhancer and promoter regions of some of the genes regulated [reviewed in [1]].
DR4 Binding (binds) of
4) Confidence 0.27 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.09
However, only reference CAR(SV1) was able to bind to the CAR-response elements DR3 of CYP3A4-XREM (Fig. 3C) and DR4(I) of MDR1 -7.8 kb enhancer (data not shown) as a heterodimer with RXR?.


DR4 Binding (bind) of in CAR
5) Confidence 0.21 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.04
The association of HLA-DR4 and HLADRw53 with VKH syndrome has been reported in the Chinese [4] and Japanese [5] populations.
HLA-DR4 Binding (association) of associated with syndrome
6) Confidence 0.20 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645903 Disease Relevance 1.04 Pain Relevance 0
DR4 is also associated with other AIDs, including HT.
DR4 Binding (associated) of associated with autoimmune disease
7) Confidence 0.17 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 1.16 Pain Relevance 0.03
The humoral response has been the main target for investigation in RP patients, but recently T-cell clones from an RP patient were reported to respond to the CII peptide residues 261-273 bound to the DR4 (*0401) molecule [18].
DR4 Binding (bound) of in T-cell associated with relapsing polychondritis
8) Confidence 0.16 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128937 Disease Relevance 1.64 Pain Relevance 0.35
HLA-class II typing revealed a non-significant trend towards an association with HLA-DR4.
HLA-DR4 Binding (association) of
9) Confidence 0.14 Published 1991 Journal Lancet Section Abstract Doc Link 1673503 Disease Relevance 0.86 Pain Relevance 0.05
In the case of EBV, this was highly associated with DR4 encoding shared epitope alleles, suggesting an important immunogenetic link.
DR4 Binding (associated) of associated with epstein-barr virus
10) Confidence 0.14 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128867 Disease Relevance 0.87 Pain Relevance 0.29
Furthermore, this syndrome demonstrates an association with HLA-DR4.
DR4 Binding (association) of associated with syndrome
11) Confidence 0.14 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128867 Disease Relevance 1.05 Pain Relevance 0.18
Susceptibility to PF has been correlated with the presence of DR4, DR14 and DR1 alleles; however, in contrast to PV, no single DR4 or DR14 allele was shown to be associated with the disease.

• In an immunogenetic study of patients with autoimmune pancreatitis, a significant increase in DR4 was found.

DR4 Binding (associated) of associated with pancreatitis, pemphigoid and disease
12) Confidence 0.13 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 1.12 Pain Relevance 0.04
An association between the HLA-DR4 haplotypes and RA has been acknowledged for many years.
DR4 Binding (association) of associated with rheumatoid arthritis
13) Confidence 0.12 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128937 Disease Relevance 1.62 Pain Relevance 0.36
This article reviews the possible pathological implications of the associations between HLA-B27, K. pneumoniae and AS, as well as HLA-DR1/DR4, P. mirabilis and RA.
DR4 Binding (associations) of associated with spinal inflammation and rheumatoid arthritis
14) Confidence 0.11 Published 2000 Journal J. Med. Microbiol. Section Abstract Doc Link 10755623 Disease Relevance 1.30 Pain Relevance 0.66
In rheumatoid arthritis (RA), >90% of patients possess either HLA-DR1 or some subtypes of HLA-DR4, whilst the frequency of this marker in the general population is c. 35%.
DR4 Binding (possess) of associated with rheumatoid arthritis
15) Confidence 0.11 Published 2000 Journal J. Med. Microbiol. Section Abstract Doc Link 10755623 Disease Relevance 1.18 Pain Relevance 0.56
Six patients were DR4 and seven were DR2 or DR3 positive, and of the five patients who were DR4 negative, four shared class I alleles often associated with DR4.
DR4 Binding (associated) of
16) Confidence 0.11 Published 2007 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC1887527 Disease Relevance 1.79 Pain Relevance 0.03
HLA associations with IgG4-associated diseases

• PV was consistently found to be associated with DR4 and DR14 and, more precisely, with DRB1*0402 and DRB1*1401 subtypes [79].

DR4 Binding (associated) of associated with pemphigoid and disease
17) Confidence 0.10 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 1.17 Pain Relevance 0.03
HLA associations with IgG4-associated diseases

• PV was consistently found to be associated with DR4 and DR14 and, more precisely, with DRB1*0402 and DRB1*1401 subtypes [79].

DR14 Binding (associated) of associated with pemphigoid and disease
18) Confidence 0.10 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 1.17 Pain Relevance 0.03
Susceptibility to PF has been correlated with the presence of DR4, DR14 and DR1 alleles; however, in contrast to PV, no single DR4 or DR14 allele was shown to be associated with the disease.

• In an immunogenetic study of patients with autoimmune pancreatitis, a significant increase in DR4 was found.

DR14 Binding (associated) of associated with pancreatitis, pemphigoid and disease
19) Confidence 0.10 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 1.12 Pain Relevance 0.04
Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease

Autoimmune hepatitis (AIH) is a chronic necroinflammatory disease of the liver characterized by hypergammaglobulinemia, characteristic autoantibodies, association with HLA DR3 or DR4 and a favorable response to immunosuppressive treatment.

DR4 Binding (association) of in liver associated with hypergammaglobulinemia, autoimmune hepatitis and disease
20) Confidence 0.09 Published 2004 Journal J Autoimmune Dis Section Title Doc Link PMC544946 Disease Relevance 1.54 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox