INT135258

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.28
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pgp)
Anatomy Link Frequency
nerve 1
capillary 1
brain 1
Pgp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 6 99.60 Very High Very High Very High
Calcitonin gene-related peptide 9 97.40 Very High Very High Very High
calcitonin gene related peptide 1 96.80 Very High Very High Very High
opiate 1 89.92 High High
Hyperalgesia 30 89.76 High High
Analgesic 1 89.36 High High
Inflammation 7 89.24 High High
Morphine 7 87.92 High High
Inflammatory mediators 1 83.80 Quite High
qutenza 39 72.48 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 6 99.60 Very High Very High Very High
Hyperalgesia 33 89.76 High High
INFLAMMATION 9 89.24 High High
Epilepsy 1 81.76 Quite High
Brain Disease 1 81.04 Quite High
Cancer 3 79.76 Quite High
Pain 14 52.28 Quite High
Necrosis 2 50.00 Quite Low
Low Back Pain 1 35.88 Quite Low
Ganglion Cysts 1 15.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis of enriched brain microvessel fractions showed increased Pgp expression 3 h post-CIP.
Gene_expression (expression) of Pgp in brain associated with ipn
1) Confidence 0.47 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17697052 Disease Relevance 1.23 Pain Relevance 1.53
Specifically, it was shown in vitro that fluvoxamine induces intermediate Pgp inhibition in MDR1 cells (model for human Pgp) as well as in primary porcine brain capillary endothelial cells (model for the BBB) (15), although this could not be confirmed in another study in MDR-1 cells (16).
Neg (inhibition) Gene_expression (inhibition) of Pgp in capillary
2) Confidence 0.41 Published 2007 Journal Pharm Res Section Body Doc Link PMC2279155 Disease Relevance 0 Pain Relevance 0.09
The anti-protein gene product 9.5 antibody (PGP; 1?
Gene_expression (The) of PGP
3) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.05 Pain Relevance 0.34
TNF expression and PGP 9.5-positive nerve in-growth in abnormal endplates may be a cause of low back pain.


Gene_expression (expression) of PGP in nerve
4) Confidence 0.02 Published 2006 Journal Spine Section Body Doc Link 16641780 Disease Relevance 0 Pain Relevance 0

General Comments

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