INT135260

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.13
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pgp) carbohydrate metabolic process (Pgp) molecular_function (Pgp)
cellular_component (Pgp)
Anatomy Link Frequency
nerve 1
brain 1
Pgp (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 7 99.14 Very High Very High Very High
dorsal root ganglion 36 96.56 Very High Very High Very High
positron emission tomography 4 93.60 High High
sodium channel 56 92.88 High High
Endep 2 86.24 High High
fluoxetine 2 85.04 High High
methadone 1 55.80 Quite High
tolerance 20 54.08 Quite High
antagonist 2 53.76 Quite High
Morphine 19 52.84 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 37 96.56 Very High Very High Very High
Cancer 54 89.08 High High
Affective Disorder 1 83.40 Quite High
Death 15 76.48 Quite High
Apoptosis 35 76.04 Quite High
Toxicity 4 64.00 Quite High
Increased Venous Pressure Under Development 6 58.24 Quite High
Autoimmune Disease 52 55.84 Quite High
Stress 52 44.32 Quite Low
Malignant Neoplastic Disease 10 20.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although data concerning the outward transport of glucocorticoids from the brain by P-glycoprotein (Pgp) are inconsistent, it has been hypothesized that antidepressants exert their clinical activity in parts by inhibiting Pgp, subsequently leading to enhanced brain glucocorticoid levels and the normalization of the HPA axis function.
Negative_regulation (inhibiting) of Pgp in brain associated with antidepressant
1) Confidence 0.42 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16641944 Disease Relevance 0.08 Pain Relevance 0.39
Cyclosporin A is currently one of the most potent Pgp inhibitors on the market for human use.
Negative_regulation (inhibitors) of Pgp
2) Confidence 0.13 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0.21
Inhibitors of Pgp have been evaluated as effective therapeutic measures for blocking the efflux of chemotherapeutics used in clinical oncology.
Negative_regulation (Inhibitors) of Pgp
3) Confidence 0.05 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.63 Pain Relevance 0.05
In contrast, robust labeling for NaV1.6, NaV1.7, NaV1.8 and NaV1.9 was exhibited in the PGP 9.5-positive axons in the small nerve bundles within the dermis.
Negative_regulation (exhibited) of PGP in nerve
4) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC3002896 Disease Relevance 0.41 Pain Relevance 0.30

General Comments

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