INT135261

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.18
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Pgp) carbohydrate metabolic process (Pgp) molecular_function (Pgp)
cellular_component (Pgp)
Anatomy Link Frequency
brain 2
Pgp (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 8 99.54 Very High Very High Very High
Opioid 2 96.08 Very High Very High Very High
Glutamate 4 95.36 Very High Very High Very High
Bioavailability 16 95.20 Very High Very High Very High
Neurotransmitter 2 93.88 High High
antagonist 1 93.52 High High
Endep 2 88.56 High High
fluoxetine 2 84.00 Quite High
fibrosis 2 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 2 61.72 Quite High
Disease 12 60.80 Quite High
Affective Disorder 1 43.40 Quite Low
Primary Sclerosing Cholangitis 6 43.20 Quite Low
Cancer 24 9.88 Low Low
Hypoxia 2 5.40 Low Low
Toxicity 8 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low
Adrenoleukodystrophy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, St John's wort is the only antidepressant tested which slightly elevated Pgp protein level in the brain.
Positive_regulation (elevated) of Pgp in brain associated with antidepressant
1) Confidence 0.68 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16641944 Disease Relevance 0 Pain Relevance 0.46
Compared with wild-type mice, drugs beings the substrate of Pgp were significantly increased in the brain of fetus when the mdr1 gene is knocked out in mice [168-171].
Positive_regulation (increased) of Pgp in brain
2) Confidence 0.52 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0 Pain Relevance 0.25
Digoxin is the substrate of Pgp and induces paclitaxel resistance by increasing Pgp [166].
Positive_regulation (increasing) of Pgp
3) Confidence 0.46 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1277830 Disease Relevance 0.18 Pain Relevance 0.17

General Comments

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