INT135262

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Context Info
Confidence 0.52
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.81
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tek) cellular_component (Tek)
Anatomy Link Frequency
brain 1
Tek (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 10 88.40 High High
Central nervous system 9 87.12 High High
cINOD 6 86.48 High High
fibrosis 90 86.28 High High
midbrain 4 66.16 Quite High
Dopamine 5 65.44 Quite High
ischemia 24 60.80 Quite High
aspirin 2 46.64 Quite Low
cytokine 13 35.44 Quite Low
Hippocampus 1 25.04 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 558 99.24 Very High Very High Very High
Toxicity 1 99.24 Very High Very High Very High
Fibrosis 96 98.00 Very High Very High Very High
Myocardial Infarction 414 97.44 Very High Very High Very High
Ventricular Remodeling 60 96.60 Very High Very High Very High
Stroke 3 91.64 High High
Stress 12 88.72 High High
INFLAMMATION 12 88.40 High High
Acute-phase Reaction 9 82.64 Quite High
Injury 4 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Toxicogenomics using a reference database can provide a better understanding and prediction of toxicity, largely by creating biomarkers that tie gene expression to actual pathology events.
Gene_expression (expression) of tie gene associated with toxicity
1) Confidence 0.52 Published 2006 Journal Toxicol Pathol Section Abstract Doc Link 16642600 Disease Relevance 0.55 Pain Relevance 0.34
Similarly, we observed a significant increase in the expression of Ang-1 (4.0-fold) and Tie-2 (2.1-fold) in the diabetic animals that received the therapy (DVAMI), 4 days after the treatment, compared with the Ad.LacZ-treated diabetic MI (DLZMI) group (Fig. 4C and D).


Gene_expression (expression) of Tie-2 associated with diabetes mellitus and myocardial infarction
2) Confidence 0.26 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.01 Pain Relevance 0
The increase in the expression of the receptors Flk-1 and Tie-2 that we observed upon gene therapy can be correlated to the increased expression of their ligands: VEGF and Ang-1, respectively.
Gene_expression (expression) of Tie-2
3) Confidence 0.26 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.05 Pain Relevance 0.03
In the present study, we observed a significant reduction in the expression of Ang-1 (2.2-fold) and Tie-2 (3.1-fold) 4 days after the surgical procedure, in the DS-operated animals compared with CS-operated animals (Fig. 4A and B).
Gene_expression (expression) of Tie-2
4) Confidence 0.26 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.90 Pain Relevance 0
Effect of gene therapy on the expression of Ang-1 and Tie-2.
Gene_expression (expression) of Tie-2
5) Confidence 0.26 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.87 Pain Relevance 0
The therapy significantly reduced the ventricular remodeling as evidenced by the significant reduction in the collagenous fibrotic tissue and improvement in the myocardial functions in conjunction with significant increase in the levels of VEGF and its receptor Flk-1, Ang-1 and its receptor Tie-2, p-MK2, and antiapoptotic survivin.
Gene_expression (levels) of Tie-2 associated with fibrosis and ventricular remodeling
6) Confidence 0.20 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.15 Pain Relevance 0.03
We also observed increased phosphorylated mitogen-activated protein kinase┬ľactivated protein kinase-2, 2 days after the treatment and increased expression of vascular endothelial growth factor (VEGF), Flk-1, angiopoietin-1 (Ang-1), Tie-2, and survivin, 4 days after treatment in the diabetic animals.
Gene_expression (expression) of Tie-2 associated with diabetes mellitus
7) Confidence 0.20 Published 2010 Journal Diabetes Section Abstract Doc Link PMC2797944 Disease Relevance 1.20 Pain Relevance 0.07
We have previously shown that precursors in the SVZ and throughout the brain express the angiopoietin receptor Tie2.
Gene_expression (express) of angiopoietin receptor in brain
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.09 Pain Relevance 0.21

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