INT135275

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.89
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 98.00 Very High Very High Very High
Kappa opioid receptor 2 95.24 Very High Very High Very High
Opioid 12 87.32 High High
cytokine 25 81.12 Quite High
rheumatoid arthritis 2 76.28 Quite High
Inflammation 38 74.68 Quite High
opioid receptor 2 68.36 Quite High
GABAergic 9 50.00 Quite Low
Hippocampus 16 45.80 Quite Low
imagery 6 30.92 Quite Low
Disease Link Frequency Relevance Heat
Aging 26 86.56 High High
Rheumatoid Arthritis 2 76.28 Quite High
Disease 39 75.04 Quite High
INFLAMMATION 41 74.68 Quite High
Stress 2 63.08 Quite High
Apoptosis 1 61.00 Quite High
Cognitive Disorder 36 50.00 Quite Low
Alzheimer's Dementia 7 27.40 Quite Low
Amyloid Plaque 4 6.20 Low Low
Urological Neuroanatomy 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that this reduction of IL-6 protein by U50,488 treatment is attributed to decreases in IL-6 mRNA.
Regulation (attributed) of Negative_regulation (decreases) of IL-6 mRNA
1) Confidence 0.45 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16644488 Disease Relevance 0.22 Pain Relevance 0.77
It is likely that this reduction of IL-6 protein by U50,488 treatment is attributed to decreases in IL-6 mRNA.
Regulation (attributed) of Negative_regulation (reduction) of IL-6
2) Confidence 0.45 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16644488 Disease Relevance 0.23 Pain Relevance 0.78
Effects of IL-6 and IL-6 deficiency on Nox2 activity: oximetry and EPR spectroscopy in synaptosomes from IL-6-treated and IL-6-/- mice
Regulation (Effects) of Negative_regulation (deficiency) of IL-6
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.09 Pain Relevance 0
This may underlie the lack of an additive or synergistic suppression of IL-6 and TNF-?
Regulation (lack) of Negative_regulation (suppression) of IL-6
4) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.36 Pain Relevance 0.12

General Comments

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