INT135292

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
PGE2 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3 100.00 Very High Very High Very High
Action potential 177 99.84 Very High Very High Very High
antagonist 5 93.32 High High
Inflammatory response 1 89.44 High High
Pyramidal cell 6 86.08 High High
Axonal channel 4 67.72 Quite High
qutenza 2 63.56 Quite High
Calcitonin gene-related peptide 3 58.52 Quite High
unmyelinated 8 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 9 85.56 High High
Increased Venous Pressure Under Development 1 36.88 Quite Low
Bordatella Infection 1 35.32 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, these findings indicate that edematogenic responses elicited by PGE2 are mediated by EP3 receptor activation, also involving the stimulation of PLC, PKC, and MAPKs pathways and the participation of TRPV1 and NK1 receptors.
Positive_regulation (stimulation) of Regulation (participation) of TRPV1 in PGE2 associated with kinase c
1) Confidence 0.43 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16644903 Disease Relevance 0.34 Pain Relevance 0.39
A counterintuitive and easily testable prediction is that decreasing temperature will increase channel noise effects on APs, e.g., as spontaneously open channels would stay open longer and increase the amount of charge delivered to the membrane [19].
Positive_regulation (increase) of Regulation (effects) of channel associated with action potential
2) Confidence 0.01 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.22

General Comments

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