INT135295

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hcrtr1) signal transducer activity (Hcrtr1)
Anatomy Link Frequency
spinal 2
forebrain 2
Hcrtr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 2 99.84 Very High Very High Very High
dorsal root ganglion 5 99.46 Very High Very High Very High
isoflurane 2 98.60 Very High Very High Very High
anesthesia 1 98.16 Very High Very High Very High
imagery 1 96.84 Very High Very High Very High
Pain 3 86.04 High High
Somatosensory cortex 1 83.04 Quite High
Spinal cord 1 81.64 Quite High
Root ganglion neuron 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 99.46 Very High Very High Very High
Pain 2 86.04 High High
Nociception 4 80.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.
Positive_regulation (increase) of Positive_regulation (activation) of orexin-1 receptor in forebrain associated with anesthesia, neuropeptide and isoflurane
1) Confidence 0.50 Published 2006 Journal Anesthesiology Section Title Doc Link 16645455 Disease Relevance 0 Pain Relevance 0.28
Moreover, by using whole-cell patch-clamp recordings and calcium imaging measurements we found that orexin A induced excitability and intracellular calcium concentration elevation in the isolated rat DRG neurons, which was mainly dependent on the activation of spinal orexin-1 receptor.
Positive_regulation (dependent) of Positive_regulation (activation) of orexin-1 receptor in spinal associated with dorsal root ganglion and imagery
2) Confidence 0.45 Published 2008 Journal Physiol Res Section Abstract Doc Link 18973425 Disease Relevance 0.92 Pain Relevance 0.51

General Comments

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